Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource  rightarrow Protein Family  rightarrow mRNA decay activator protein  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • AID Antibody
 • MB21D1 siRNA
 • gamma-interferon (IFN ppar-gamma) ELISA Kit
 • Glycine receptor subunit alpha-1 (Glra1) Recombinant Protein
 • glutathione S-transferase pi 1 (GSTP1) ELISA Kit
 • BF ELISA Kit
 • p38 MAP Kinase (Thr-180-Tyr-182) (LOC100533304) Antibody
 • R3H domain containing 1 (R3HDM1) ELISA Kit
 • Orexin A (OX-A) ELISA Kit
 • alpha-Endomorphin (alpha-EP) ELISA Kit
 • natriuretic peptide precursor C (NPPC) ELISA Kit
 • DLX1 Antibody
 • tubby homolog (mouse) ELISA Kit
 • Lipoprotein Receptor-related Protein Associated Protein 1, L... Antibody
 downarrow more ...
separator

mRNA decay activator protein

separator
Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis .

Below are the list of possible mRNA decay activator protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

mRNA decay activator protein ZFP36

 mRNA decay activator protein ZFP36 ELISA Kit
 mRNA decay activator protein ZFP36 Recombinant
 mRNA decay activator protein ZFP36 Antibody
Also known as mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36).
TTP: a CCCH zinc finger protein that has anti-inflammatory and arthritis suppressor activity. Regulates inflammatory responses at the post-transcriptional level. TTP deficiency in mice causes a severe inflammatory syndrome that includes autoimmunity, myeloid hyperplasia, and erosive arthritis. Binds to and destabilizes mRNA molecules with AU-rich elements (AREs). Has a high affinity for UUAUUUAUU mRNA sequ
>>>
ences. Destabilizes tumor necrosis factor-alpha (TNF??), interleukin 2 (IL2), granulocyte-macrophage colony-stimulating factor (GM-CSF), transcription factor E47, and cyclooxygenase 2 (COX2) mRNAs. TNF?? and GM-CSF mRNAs are stabilized in TTP-deficient mice, causing a severe inflammatory syndrome. Conversely, high levels of TTP reduce inflammatory responses. TTP is a very low abundance protein that is rapidly induced by insulin, glucocorticoids, lipopolysaccharide (LPS), fetal calf serum, zinc, herpes simplex virus 1, green tea, and cinnamon. Once induced, the TTP protein is relatively stable. Has been experimentaly shown to be able to bind zinc. TTP is extensively phosphorylated.

Protein type: DNA-binding; RNA-binding

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: CCR4-NOT complex; cytoplasm; cytosol; exosome (RNase complex); nucleus; ribonucleoprotein complex; stress granule

Molecular Function: AU-rich element binding; C-C chemokine binding; enzyme binding; heat shock protein binding; mRNA 3'-UTR binding; mRNA binding; protein binding; protein kinase binding; single-stranded RNA binding

Biological Process: MAPKKK cascade; miRNA-mediated gene silencing, negative regulation of translation; mRNA catabolic process; mRNA catabolic process, deadenylation-dependent decay; mRNA catabolic process, deadenylation-independent decay; mRNA transport; negative regulation of erythrocyte differentiation; negative regulation of interleukin-2 biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of viral transcription; poly(A) tail shortening; positive regulation of fat cell differentiation; regulation of keratinocyte differentiation; regulation of mRNA stability; regulation of tumor necrosis factor production; response to starvation; response to wounding
 ZFP36 ELISA Kit
 ZFP36 Recombinant
 ZFP36 Antibody
 G0S24 ELISA Kit
 G0S24 Recombinant
 G0S24 Antibody
 NUP475 ELISA Kit
 NUP475 Recombinant
 NUP475 Antibody
 RNF162A ELISA Kit
 RNF162A Recombinant
 RNF162A Antibody
Table BarTOPTable Bar
 

mRNA decay activator protein ZFP36L1

 mRNA decay activator protein ZFP36L1 ELISA Kit
 mRNA decay activator protein ZFP36L1 Recombinant
 mRNA decay activator protein ZFP36L1 Antibody
Also known as mRNA decay activator protein ZFP36L1 (Butyrate response factor 1) (EGF-inducible protein CMG1) (TPA-induced sequence 11b) (Zinc finger protein 36, C3H1 type-like 1) (ZFP36-like 1).
BRF1: a zinc finger protein that plays an important role in the assembly of the RNA polymerase III initiation factor TFIIIB. Regulates mRNA levels by targeting transcripts containing AREs (AU-rich elements) into the decay pathway. Phosphorylation by Akt apparently generates 14-3-3 binding sites and inhibits BRF1 from promoting mRNA activity.Contains 2 C3H1-type zinc fingers.

Protein type: Tra
>>>
nscription factor

Cellular Component: cytoplasm; cytosol; nucleus; ribonucleoprotein complex

Molecular Function: AU-rich element binding; mRNA 3'-UTR binding; mRNA binding

Biological Process: apoptosis; cell proliferation; cellular response to insulin stimulus; embryonic organ development; heart development; MAPKKK cascade; mesendoderm development; mRNA catabolic process; mRNA catabolic process, deadenylation-dependent decay; mRNA catabolic process, deadenylation-independent decay; mRNA transport; multicellular organism growth; negative regulation of erythrocyte differentiation; neural tube development; phosphoinositide 3-kinase cascade; positive regulation of fat cell differentiation; positive regulation of monocyte differentiation; protein kinase B signaling cascade; regulation of B cell differentiation; regulation of gene expression; regulation of keratinocyte differentiation; regulation of mRNA stability; regulation of myoblast differentiation; regulation of translation; response to wounding; T cell differentiation in the thymus; vasculogenesis
 Zfp36l1 ELISA Kit
 Zfp36l1 Recombinant
 Zfp36l1 Antibody
 Brf1 ELISA Kit
 Brf1 Recombinant
 Brf1 Antibody
 Cmg1 ELISA Kit
 Cmg1 Recombinant
 Cmg1 Antibody
 Tis11b ELISA Kit
 Tis11b Recombinant
 Tis11b Antibody
Table BarTOPTable Bar
 

mRNA decay activator protein ZFP36L2

 mRNA decay activator protein ZFP36L2 ELISA Kit
 mRNA decay activator protein ZFP36L2 Recombinant
 mRNA decay activator protein ZFP36L2 Antibody
Also known as mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2).
ZFP36L2: Probable regulatory protein involved in regulating the response to growth factors. RNA-binding protein that binds to 5'UUAUUUAUUU-3' core sequence. Binds to the class II AU-rich element (ARE) in the 3'-UTR of target mRNAs and promotes their deadenylation and degradation.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 2p22.3-p21

Cellular Co
>>>
mponent: cytoplasm; cytosol; nucleus

Molecular Function: AU-rich element binding; mRNA 3'-UTR binding; protein binding; transcription factor activity

Biological Process: cell proliferation; hemopoiesis; mRNA catabolic process; negative regulation of fat cell differentiation; regulation of B cell differentiation; regulation of mRNA stability; response to wounding; somatic stem cell division; somatic stem cell maintenance; T cell differentiation in the thymus
 ZFP36L2 ELISA Kit
 ZFP36L2 Recombinant
 ZFP36L2 Antibody
 BRF2 ELISA Kit
 BRF2 Recombinant
 BRF2 Antibody
 ERF2 ELISA Kit
 ERF2 Recombinant
 ERF2 Antibody
 RNF162C ELISA Kit
 RNF162C Recombinant
 RNF162C Antibody
Table BarTOPTable Bar
 

mRNA decay activator protein ZFP36L2-A

 mRNA decay activator protein ZFP36L2-A ELISA Kit
 mRNA decay activator protein ZFP36L2-A Recombinant
 mRNA decay activator protein ZFP36L2-A Antibody
Also known as mRNA decay activator protein ZFP36L2-A (CCCH zinc finger protein 3-A) (XC3H-3) (Zinc finger protein 36, C3H1 type-like 2-A).
Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10751406
>>>
, PubMed:12748283). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12748283). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (PubMed:10751406, PubMed:11279239). Required for tubulogenesis during pronephros development ().
 zfp36l2-A ELISA Kit
 zfp36l2-A Recombinant
 zfp36l2-A Antibody
Table BarTOPTable Bar
 

mRNA decay activator protein ZFP36L2-B

 mRNA decay activator protein ZFP36L2-B ELISA Kit
 mRNA decay activator protein ZFP36L2-B Recombinant
 mRNA decay activator protein ZFP36L2-B Antibody
Also known as mRNA decay activator protein ZFP36L2-B (CCCH zinc finger protein 3-B) (XC3H-3b) (Zinc finger protein 36, C3H1 type-like 2-B).
Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:1075140
>>>
6). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12914788). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (). Required for tubulogenesis during pronephros development (PubMed:12914788).
 zfp36l2-B ELISA Kit
 zfp36l2-B Recombinant
 zfp36l2-B Antibody
 zfp36l2 ELISA Kit
 zfp36l2 Recombinant
 zfp36l2 Antibody
Table BarTOPTable Bar
Proteins Root Name Listing
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions