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mRNA interferase

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Toxic component of a toxin-antitoxin (TA) module. A probable translation-dependent mRNA interferase. Probably counteracted by antitoxin HigA.

Below are the list of possible mRNA interferase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

mRNA interferase HigB

 mRNA interferase HigB ELISA Kit
 mRNA interferase HigB Recombinant
 mRNA interferase HigB Antibody
Also known as mRNA interferase HigB (Endoribonuclease HigB) (Toxin HigB).
Toxic component of a toxin-antitoxin (TA) module. A probable translation-dependent mRNA interferase. Probably counteracted by antitoxin HigA.
 higB ELISA Kit
 higB Recombinant
 higB Antibody
 c3274 ELISA Kit
 c3274 Recombinant
 c3274 Antibody
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mRNA interferase MqsR

 mRNA interferase MqsR ELISA Kit
 mRNA interferase MqsR Recombinant
 mRNA interferase MqsR Antibody
Also known as mRNA interferase MqsR (Endoribonuclease MqsR) (Motility quorum-sensing regulator MqsR) (Toxin MqsR).
Toxic component of a type II toxin-antitoxin (TA) module. Plays a significant role in the control of biofilm formation and induction of persister cells in the presence of antibiotics. An mRNA interferase which has been reported to be translation-independent (PubMed:19690171, PubMed:19943910, PubMed:23289863). It has also been reported to be translation-dependent (PubMed:20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed:19690171). Als
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o reported to cleave after C in GC(A/U) sequences (PubMed:19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity; among these is the gene for toxin GhoT. Overexpression of MqsR causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation; these effects are overcome by concomitant or subsequent expression of antitoxin MqsA. Cross-talk can occur between different TA modules. Ectopic expression of this toxin induces transcription of the relBEF TA module operon with specific cleavage of the relBEF mRNA produced (PubMed:23432955). Regulates the expression of GhoT/GhoS, a type V TA module (PubMed:23289863). Persistence depends on toxin GhoT activity, which MqsR controls at the post-transcriptional level by selectively degrading the antitoxin ghoS segment of the ghoST mRNA (PubMed:23289863). Persister cells exhibit antibiotic tolerance without genetic change. Overexpression leads to a dramatic increase in tolerance to the antibiotic ofloxacin. This TA system mediates cell growth during bile acid deoxycholate stress by degrading mRNA for probable deoxycholate-binding protein YgiS; bile acid detergents such as deoxycholate are important for host defense against bacterial growth in the gall bladder and duodenum (PubMed:25534751).
 mqsR ELISA Kit
 mqsR Recombinant
 mqsR Antibody
 ygiU ELISA Kit
 ygiU Recombinant
 ygiU Antibody
 b3022 ELISA Kit
 b3022 Recombinant
 b3022 Antibody
 JW2990 ELISA Kit
 JW2990 Recombinant
 JW2990 Antibody
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mRNA interferase RelE

 mRNA interferase RelE ELISA Kit
 mRNA interferase RelE Recombinant
 mRNA interferase RelE Antibody
Also known as mRNA interferase RelE (Endoribonuclease RelE) (Toxin RelE).
Toxic component of a toxin-antitoxin (TA) module. A sequence-specific, ribosome-dependent mRNA endoribonuclease that inhibits translation during amino acid starvation (the stringent response). Acts by cleaving mRNA with high codon specificity in the ribosomal A site between positions 2 and 3. Acts with RelB as a corepressor of relBE transcription ().
 relE ELISA Kit
 relE Recombinant
 relE Antibody
 relE1 ELISA Kit
 relE1 Recombinant
 relE1 Antibody
 SF1548 ELISA Kit
 SF1548 Recombinant
 SF1548 Antibody
 S1669 ELISA Kit
 S1669 Recombinant
 S1669 Antibody
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mRNA interferase YafO

 mRNA interferase YafO ELISA Kit
 mRNA interferase YafO Recombinant
 mRNA interferase YafO Antibody
Also known as mRNA interferase YafO (Endoribonuclease YafO) (Toxin YafO).
Toxic component of a toxin-antitoxin (TA) module. A translation-dependent mRNA interferase. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation; this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome; YafO alone is not able to diges
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t mRNA.
 yafO ELISA Kit
 yafO Recombinant
 yafO Antibody
 b0233 ELISA Kit
 b0233 Recombinant
 b0233 Antibody
 JW0223 ELISA Kit
 JW0223 Recombinant
 JW0223 Antibody
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mRNA interferase YafQ

 mRNA interferase YafQ ELISA Kit
 mRNA interferase YafQ Recombinant
 mRNA interferase YafQ Antibody
Also known as mRNA interferase YafQ (Endoribonuclease YafQ) (Toxin YafQ).
Toxic component of a toxin-antitoxin (TA) module. A sequence-specific mRNA endoribonuclease that inhibits translation elongation and induces bacterial stasis. Cleavage occurs between the second and third residue of the Lys codon followed by a G or A (5'AAA(G/A)3'), is reading-frame dependent and occurs within the 5' end of most mRNAs. Ribosome-binding confers the sequence specificity and reading frame-dependence. When overexpressed in liquid media YafQ partially inhibits protein synthesis, with a reduction in growth r
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ate and colony growth rate. This effect is counteracted by coexpression with DinJ, the YafQ antitoxin. YafQ and DinJ together bind their own promoter, and by analogy to other TA modules probably repress its expression.
 yafQ ELISA Kit
 yafQ Recombinant
 yafQ Antibody
 b0225 ELISA Kit
 b0225 Recombinant
 b0225 Antibody
 JW0215 ELISA Kit
 JW0215 Recombinant
 JW0215 Antibody
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