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Msx2-interacting protein

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May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.

Below are the list of possible Msx2-interacting protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Msx2-interacting protein

 Msx2-interacting protein ELISA Kit
 Msx2-interacting protein Recombinant
 Msx2-interacting protein Antibody
Also known as Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog).
SHARP: May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2- mediated activation of the osteocalcin FGF-responsive element (OCFRE). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the associa
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tion between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. Belongs to the RRM Spen family.

Protein type: Nuclear receptor co-regulator; RNA-binding; Spliceosome; Transcription factor

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: nucleoplasm; nucleus; transcriptional repressor complex

Molecular Function: nucleic acid binding; protein binding

Biological Process: negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear mRNA splicing, via spliceosome; positive regulation of neurogenesis
 SPEN ELISA Kit
 SPEN Recombinant
 SPEN Antibody
 KIAA0929 ELISA Kit
 KIAA0929 Recombinant
 KIAA0929 Antibody
 MINT ELISA Kit
 MINT Recombinant
 MINT Antibody
 SHARP ELISA Kit
 SHARP Recombinant
 SHARP Antibody
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