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Mu-conotoxins block voltage-gated sodium channels (Nav). This synthetic toxin potently blocks rNav1.2/SCN2A, and rNav1.4/SCN4A. It also moderately blocks rNav1.1/SCN1A, rNav1.3/SCN3A, rNav1.5/SCN5A, and mNav1.6/SCN8A. The inhibition is reversible.
Below are the list of possible Mu-conotoxin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications. |
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Mu-conotoxin cal12a ELISA Kit Mu-conotoxin cal12a Recombinant Mu-conotoxin cal12a Antibody | Also known as Mu-conotoxin cal12a (Conotoxin Cal 12.1.1a) (Conotoxin CalTx 12.1.1A). Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin reversibly blocks voltage-gated sodium chann >>> el in cephalopods (tested on squid giant-fiber-lobe neurons) with an inhibitor constant (Ki) of 15 nmol/l, with no alteration in the voltage dependence of sodium conductance or on the kinetics of inactivation. Has no effect on sodium channels of the two gastropod S.luhuanus and A.californica (which are not natural prey). |
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Mu-conotoxin cal12b ELISA Kit Mu-conotoxin cal12b Recombinant Mu-conotoxin cal12b Antibody | Also known as Mu-conotoxin cal12b (Conotoxin Cal 12.1.1b) (Conotoxin CalTx 12.1.1B). Mu-conotoxins block voltage-gated sodium channels. This toxin reversibly blocks voltage-gated sodium channel in >>> cephalopods (tested on squid giant-fiber-lobe neurons) with an inhibitor constant (Ki) of 15 nmol/l, with no alteration in the voltage dependence of sodium conductance or on the kinetics of inactivation. Has no effect on sodium channels of the two gastropod S.luhuanus and A.californica (which are not natural prey). |
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Mu-conotoxin CnIIIC ELISA Kit Mu-conotoxin CnIIIC Recombinant Mu-conotoxin CnIIIC Antibody | Mu-conotoxins block voltage-gated sodium channels (Nav). This synthetic toxin blocks both voltage-gated sodium channels and nicotinic acetylcholine receptor (nAChR). Inhibits the skeletal muscle rNav1 >>> .4/SCN4A (IC50=1.3 nM) and the brain rNav1.2/SCN2A in a long-lasting manner. A low inhibition is also observed on neuronal mNav1.6/SCN8A and mNav1.7/SCN9A. Modestly blocks nAChR alpha-3/beta-2 subtype (IC50=450 nM) (partially reversible) and, to a lesser extent, alpha-7 and alpha-4/beta-2 subtypes (reversible). In vitro, decreases twitch tension in mouse hemidiaphragms (IC50=150 nM), and displays a high blocking effect in mouse extensor digitorum longus muscles (IC50=46 nM). |
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Mu-conotoxin KIIIA ELISA Kit Mu-conotoxin KIIIA Recombinant Mu-conotoxin KIIIA Antibody | Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin potently blocks rNav1.2/SCN2A and rNav1.4/SCN4A. It also moderately blocks rNav1.1/SCN1A, rNav1.3/SCN3A, rNav1.5/SCN5A, mNav1.6/SCN8 >>> A, and rNav1.7/SCN9A. On rNav1.2/SCN2A, it produces a block that is only partially reversible. The block of SCN9A is modified when beta-subunits are coexpressed with the alpha subunit. Hence, blocks of channels containing beta-1 and beta-3 subunits are more potent (compared to channels without beta subunits), whereas blocks of channels containing beta-2 and beta-4 subunits are less potent (compared to channels without beta subunits). |
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Mu-conotoxin MrVIA ELISA Kit Mu-conotoxin MrVIA Recombinant Mu-conotoxin MrVIA Antibody | Also known as Mu-conotoxin MrVIA (Conotoxin Mr6.5). Mu-conotoxins block voltage-gated sodium channels. Has a preference for Nav1.4/SCN4A over Nav1.2/SCN2A. Blocks Nav channels by interacting mainly >>> with the C-terminal part of the pore loop of domain-3. Does not bind on site 1. At small concentration, this toxin also acts as a calcium current agonist, whereas at higher doses it blocks fast-inactivating calcium current. |
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Mu-conotoxin MrVIB ELISA Kit Mu-conotoxin MrVIB Recombinant Mu-conotoxin MrVIB Antibody | Also known as Mu-conotoxin MrVIB (CGX-1002). Mu-conotoxins block voltage-gated sodium channels. Has a preference for Nav1.4/SCN4A over Nav1.2/SCN2A sodium channels. Blocks Nav channels by interacti >>> ng mainly with the C-terminal part of the pore loop of domain-3. Also blocks fast-inactivating calcium current. Blocks Nav1.8/SCN10A sodium channels and has potent and long-lasting local anesthetic effects. Can also block propagation of action potentials in A- and C-fibers in sciatic nerve as well as skeletal muscle in isolated preparations. |
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Mu-conotoxin PIIIA ELISA Kit Mu-conotoxin PIIIA Recombinant Mu-conotoxin PIIIA Antibody | Also known as Mu-conotoxin PIIIA (Mu-conotoxin P3.7). Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin potently blocks rNav1.4/SCN4A. It also moderately blocks rNav1.1/SCN1A, rNa >>> v1.2/SCN2A, rNav1.3/SCN3A, mNav1.6/SCN8A, and h/rNav1.7/SCN9A. This inhibition is reversible. The block of SCN1A, SCN2A, and SCN8A is modified when beta-subunits are coexpressed with alpha subunits. Hence, blocks of channels containing the beta-1 and beta-3 subunits are more potent (compared to channels without beta subunits), whereas blocks of channels containing the beta-2 and beta-4 are less potent (compared to channels without beta subunits). This peptide causes flaccid paralysis in both mice and fish. |
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Mu-conotoxin PnIVA ELISA Kit Mu-conotoxin PnIVA Recombinant Mu-conotoxin PnIVA Antibody | Mu-conotoxins block voltage-gated sodium channels (Nav). Blocks reversibly sodium channels in molluskan neurons, but has no effect on sodium currents in bovine chromaffin cells or in rat brain synapto >>> somes. Induces paralysis in bivalve mollusks (Mytilus). No effect are observed on fish (Gambusia) and fly larvae (Sarcophaga). PnIVB is approximately 6 times more potent than PnIVA in blockade of the sodium current in Lymnaea neurons. |
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Mu-conotoxin PnIVB ELISA Kit Mu-conotoxin PnIVB Recombinant Mu-conotoxin PnIVB Antibody | Mu-conotoxins block voltage-gated sodium channels (Nav). Blocks reversibly sodium channels in molluskan neurons, but has no effect on sodium currents in bovine chromaffin cells or in rat brain synapto >>> somes. Induces paralysis in bivalve mollusks (Mytilus). No effect are observed on fish (Gambusia) and fly larvae (Sarcophaga). Is approximately 6 times more potent than PnIVA in blockade of the sodium current in Lymnaea neurons. |
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Mu-conotoxin SmIIIA ELISA Kit Mu-conotoxin SmIIIA Recombinant Mu-conotoxin SmIIIA Antibody | Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin blocks rNav1.5/SCN5A (IC50 is 1.3 µM), rNav1.6/SCN8A (IC50 is 160 nM), rNav1.7/SCN9A (IC50 is 1.3 µM), rNav1.1/SCN1A (K(d) is 3.8 >>> nM), rNav1.2/SCN2A (K(d) is 1.3 nM), rNav1.4/SCN4A (K(d) is 0.22 nM), rNav1.6/SCN8A (K(d) is 69 nM), and rNav1.7/SCN9A (K(d) is 260 nM). This toxin is very potent but weakly discriminating among sodium channels. The block of these channels is modified when beta-subunits are coexpressed with alpha subunits. Hence, blocks of channels containing beta-1 and beta-3 subunits are more potent (compared to channels without beta subunits), whereas blocks of channels containing beta-2 and beta-4 subunits are less potent (compared to channels without beta subunits). |
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Mu-conotoxin TIIIA ELISA Kit Mu-conotoxin TIIIA Recombinant Mu-conotoxin TIIIA Antibody | Mu-conotoxins block voltage-gated sodium channels (Nav). This synthetic toxin reversibly and potently blocks rNav1.4/SCN4A (IC50 is 9 nM) and rNav1.2/SCN2A (IC50 is 40 nM). It also moderately blocks r >>> Nav1.1/SCN1A, rNav1.3/SCN3A, and rNav1.6/SCN8A. The block of SCN1A and SCN2A is modified when beta-subunits are coexpressed with alpha subunits. Hence, blocks of channels containing beta-1 and beta-3 subunits are more potent (compared to channels without beta subunits), whereas blocks of channels containing beta-2 and beta-4 subunits are less potent (compared to channels without beta subunits). |
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