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Mucin

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The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.; The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.

Below are the list of possible Mucin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Mucin-1

 Mucin-1 ELISA Kit
 Mucin-1 Recombinant
 Mucin-1 Antibody
Also known as Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227).
MUC1: a large cell surface glyco
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protein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. Plays a role in adhesion and cell-cell interactions, metastasis and signaling. May provide a protective layer on epithelial surfaces. Direct or indirect interaction with actin cytoskeleton. Its cytoplasmic tail (MUC1CT) is involved in several signaling pathways, including those involving Ras, beta-catenin, p120 catenin, p53 and estrogen receptor alpha. MUC1CT also forms complexes with transcription factors, and then translocates to the nucleus by an unknown mechanism, where it is believed to influence the transcription of their target genes. MUC1CT has also been proposed to localize to mitochondrial membranes under conditions of genotoxic stress, where it attenuates the apoptotic pathway in response and confers resistance to apoptosis-inducing drugs. Aberrantly glycosylated forms expressed in human epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Nine alternatively spliced isoforms have been described. Isoforms 5 and 9 are secreted. Isoform 7, expressed only in tumor cells, is a receptor and binds the secreted isoform 5. The binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling. Can bind to GRB2 adapter protein.

Protein type: Actin-binding; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Tumor suppressor

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: extracellular space; Golgi lumen; integral to plasma membrane; nuclear chromatin; vesicle

Molecular Function: p53 binding; protein binding; transcription cofactor activity

Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; negative regulation of cell adhesion mediated by integrin; O-glycan processing; regulation of transcription from RNA polymerase II promoter in response to stress

Disease: Medullary Cystic Kidney Disease 1
 MUC1 ELISA Kit
 MUC1 Recombinant
 MUC1 Antibody
 PUM ELISA Kit
 PUM Recombinant
 PUM Antibody
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Mucin-12

 Mucin-12 ELISA Kit
 Mucin-12 Recombinant
 Mucin-12 Antibody
Also known as Mucin-12 (MUC-12) (Mucin-11) (MUC-11).
MUC12: Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q22

Cellula
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r Component: Golgi lumen

Biological Process: O-glycan processing
 MUC12 ELISA Kit
 MUC12 Recombinant
 MUC12 Antibody
 MUC11 ELISA Kit
 MUC11 Recombinant
 MUC11 Antibody
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Mucin-13

 Mucin-13 ELISA Kit
 Mucin-13 Recombinant
 Mucin-13 Antibody
Also known as Mucin-13 (MUC-13).
human homolog may play a role in epithelial tissue barrier function [RGD, Feb 2006]
 Muc13 ELISA Kit
 Muc13 Recombinant
 Muc13 Antibody
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Mucin-15

 Mucin-15 ELISA Kit
 Mucin-15 Recombinant
 Mucin-15 Antibody
Also known as Mucin-15 (MUC-15).
MUC15: May play a role in the cell adhesion to the extracellular matrix. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral
 Muc15 ELISA Kit
 Muc15 Recombinant
 Muc15 Antibody
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Mucin-16

 Mucin-16 ELISA Kit
 Mucin-16 Recombinant
 Mucin-16 Antibody
Also known as Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125).
MUC16: Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.

Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, peripheral

Chromosomal Location of Human Ortholog: 19p13.2

C
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ellular Component: extrinsic to membrane; Golgi lumen; vesicle

Molecular Function: protein binding

Biological Process: O-glycan processing
 MUC16 ELISA Kit
 MUC16 Recombinant
 MUC16 Antibody
 CA125 ELISA Kit
 CA125 Recombinant
 CA125 Antibody
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Mucin-17

 Mucin-17 ELISA Kit
 Mucin-17 Recombinant
 Mucin-17 Antibody
Also known as Mucin-17 (MUC-17) (Small intestinal mucin-3) (MUC-3).
MUC17: Probably plays a role in maintaining homeostasis on mucosal surfaces. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: apical p
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lasma membrane; external side of plasma membrane; Golgi lumen

Molecular Function: PDZ domain binding; protein binding

Biological Process: cellular homeostasis; O-glycan processing
 MUC17 ELISA Kit
 MUC17 Recombinant
 MUC17 Antibody
 MUC3 ELISA Kit
 MUC3 Recombinant
 MUC3 Antibody
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Mucin-19

 Mucin-19 ELISA Kit
 Mucin-19 Recombinant
 Mucin-19 Antibody
Also known as Mucin-19 (MUC-19).
MUC19: May function in ocular mucus homeostasis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: Golgi lumen

Biological Process: O-glycan processing
 MUC19 ELISA Kit
 MUC19 Recombinant
 MUC19 Antibody
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Mucin-2

 Mucin-2 ELISA Kit
 Mucin-2 Recombinant
 Mucin-2 Antibody
Also known as Mucin-2 (MUC-2) (Colonic mucin) (MCM) (Secreted gel-forming mucin) (Fragments).
Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in ex
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cluding bacteria from the inner mucus layer.
 Muc2 ELISA Kit
 Muc2 Recombinant
 Muc2 Antibody
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Mucin-20

 Mucin-20 ELISA Kit
 Mucin-20 Recombinant
 Mucin-20 Antibody
Also known as Mucin-20 (MUC-20).
MUC20: May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression. 2 isoforms of the human protein are produced by alternative splicing.

Cellular Component: basal
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plasma membrane; plasma membrane

Molecular Function: protein binding

Biological Process: activation of MAPK activity; hepatocyte growth factor receptor signaling pathway; protein homooligomerization
 Muc20 ELISA Kit
 Muc20 Recombinant
 Muc20 Antibody
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Mucin-21

 Mucin-21 ELISA Kit
 Mucin-21 Recombinant
 Mucin-21 Antibody
Also known as Mucin-21 (MUC-21) (Epiglycanin).
MUC21: 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.32

Cellular Component: Golgi lumen; plasma membrane

Biological Process: negative regulation of cell-cell adhesion; O-glycan processing
 MUC21 ELISA Kit
 MUC21 Recombinant
 MUC21 Antibody
 C6orf205 ELISA Kit
 C6orf205 Recombinant
 C6orf205 Antibody
 UNQ697/PRO1342 ELISA Kit
 UNQ697/PRO1342 Recombinant
 UNQ697/PRO1342 Antibody
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Mucin-22

 Mucin-22 ELISA Kit
 Mucin-22 Recombinant
 Mucin-22 Antibody
Also known as Mucin-22 (Panbronchiolitis-related mucin-like protein 1).
PBMUCL1: Up-regulated by poly(I:C).

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.33
 MUC22 ELISA Kit
 MUC22 Recombinant
 MUC22 Antibody
 G4 ELISA Kit
 G4 Recombinant
 G4 Antibody
 PBMUCL1 ELISA Kit
 PBMUCL1 Recombinant
 PBMUCL1 Antibody
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Mucin-3A

 Mucin-3A ELISA Kit
 Mucin-3A Recombinant
 Mucin-3A Antibody
Also known as Mucin-3A (MUC-3A) (Intestinal mucin-3A).
MUC3A: Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane p
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rotein, integral

Chromosomal Location of Human Ortholog: 7q22

Cellular Component: apical plasma membrane; extracellular space; Golgi lumen

Biological Process: O-glycan processing

Disease: Inflammatory Bowel Disease 11
 MUC3A ELISA Kit
 MUC3A Recombinant
 MUC3A Antibody
 MUC3 ELISA Kit
 MUC3 Recombinant
 MUC3 Antibody
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Mucin-3B

 Mucin-3B ELISA Kit
 Mucin-3B Recombinant
 Mucin-3B Antibody
Also known as Mucin-3B (MUC-3B) (Intestinal mucin-3B) (Fragments).
MUC3B: Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.

Chromosomal Location of Human Ortholog: 7q22

Cellular Component: apical plasma membrane; extracellular space; Golgi lumen

Biologica
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l Process: O-glycan processing
 MUC3B ELISA Kit
 MUC3B Recombinant
 MUC3B Antibody
Table BarTOPTable Bar
 

Mucin-4

 Mucin-4 ELISA Kit
 Mucin-4 Recombinant
 Mucin-4 Antibody
Also known as Mucin-4 (MUC-4) (Ascites sialoglycoprotein) (ASGP) (Pancreatic adenocarcinoma mucin) (Pre-sialomucin complex) (pSMC) (Sialomucin complex) (Testis mucin).
May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhe
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sive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248' ().
 Muc4 ELISA Kit
 Muc4 Recombinant
 Muc4 Antibody
 Smc ELISA Kit
 Smc Recombinant
 Smc Antibody
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Mucin-5AC

 Mucin-5AC ELISA Kit
 Mucin-5AC Recombinant
 Mucin-5AC Antibody
Also known as Mucin-5AC (MUC-5AC) (Gastric mucin) (Lewis B blood group antigen) (LeB) (Major airway glycoprotein) (Mucin-5 subtype AC, tracheobronchial) (Tracheobronchial mucin) (TBM).
MUC5AC iso1:

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: cytoplasm; extracellular space; Golgi lumen

Molecular Function: extracellular matrix structural constituent >>>
r>
Biological Process: O-glycan processing; phosphoinositide-mediated signaling
 MUC5AC ELISA Kit
 MUC5AC Recombinant
 MUC5AC Antibody
 MUC5 ELISA Kit
 MUC5 Recombinant
 MUC5 Antibody
Table BarTOPTable Bar
 

Mucin-5B

 Mucin-5B ELISA Kit
 Mucin-5B Recombinant
 Mucin-5B Antibody
Also known as Mucin-5B (MUC-5B) (Cervical mucin) (High molecular weight salivary mucin MG1) (Mucin-5 subtype B, tracheobronchial) (Sublingual gland mucin).
MUC5B: Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. Defects in MUC5B are a cause of susceptibility to pulmonary fibrosis idiopathic (IPF). Pulmonary fibros
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is is a lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. It results in acute lung injury with subsequent scarring and endstage lung disease. A common polymorphism in the promoter of MUC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrosis, suggesting that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis (PubMed:21506741).

Protein type: Cell adhesion; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: extracellular space; Golgi lumen; intracellular membrane-bound organelle

Molecular Function: protein binding

Biological Process: O-glycan processing

Disease: Pulmonary Fibrosis, Idiopathic
 MUC5B ELISA Kit
 MUC5B Recombinant
 MUC5B Antibody
 MUC5 ELISA Kit
 MUC5 Recombinant
 MUC5 Antibody
Table BarTOPTable Bar
 

Mucin-6

 Mucin-6 ELISA Kit
 Mucin-6 Recombinant
 Mucin-6 Antibody
Also known as Mucin-6 (MUC-6) (Gastric mucin-6).
MUC6: May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis
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.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: Golgi lumen

Biological Process: O-glycan processing
 MUC6 ELISA Kit
 MUC6 Recombinant
 MUC6 Antibody
Table BarTOPTable Bar
 

Mucin-7

 Mucin-7 ELISA Kit
 Mucin-7 Recombinant
 Mucin-7 Antibody
Also known as Mucin-7 (MUC-7) (Apo-MG2) (Salivary mucin-7).
MUC7: May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili. Genetic variations in MUC7 are associated with susceptibility to asthma (ASTHMA). The most common chronic disease affecting children and young adults. It is a
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complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: Golgi lumen

Molecular Function: protein binding

Biological Process: O-glycan processing

Disease: Asthma, Susceptibility To
 MUC7 ELISA Kit
 MUC7 Recombinant
 MUC7 Antibody
 MG2 ELISA Kit
 MG2 Recombinant
 MG2 Antibody
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Proteins Root Name Listing
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