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Multidrug resistance-associated protein

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Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.

Below are the list of possible Multidrug resistance-associated protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Multidrug resistance-associated protein 1

 Multidrug resistance-associated protein 1 ELISA Kit
 Multidrug resistance-associated protein 1 Recombinant
 Multidrug resistance-associated protein 1 Antibody
Also known as Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter).
ABCC1: a multi-pass membrane protein. A multidrug resistance member of the ABC transporter family that confers resistance to anticancer drugs. A multi-pass membrane protein. Exports sphingosine-1-phosphate (S1P), a potent inflammatory mediator, from mast cells during mast cell-mediated immune responses. Nine alternatively spliced human isoforms have been reported.

Protein type: Membrane protein, integral; Membrane protein, multi-pass
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; Transporter; Transporter, ABC family

Cellular Component: basolateral plasma membrane; cytoplasm; integral to plasma membrane; membrane; plasma membrane

Molecular Function: ATPase activity; drug transporter activity; efflux transmembrane transporter activity; glutathione S-conjugate-exporting ATPase activity; lipid-transporting ATPase activity; long-chain fatty acid transporter activity; sphingolipid transporter activity; xenobiotic-transporting ATPase activity

Biological Process: daunorubicin transport; drug export; multidrug transport; phospholipid efflux; plasma membrane long-chain fatty acid transport; positive regulation of cell migration; response to drug; response to oxidative stress; transmembrane transport; xenobiotic transport
 Abcc1 ELISA Kit
 Abcc1 Recombinant
 Abcc1 Antibody
 Abcc1a ELISA Kit
 Abcc1a Recombinant
 Abcc1a Antibody
 Abcc1b ELISA Kit
 Abcc1b Recombinant
 Abcc1b Antibody
 Mdrap ELISA Kit
 Mdrap Recombinant
 Mdrap Antibody
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Multidrug resistance-associated protein 4

 Multidrug resistance-associated protein 4 ELISA Kit
 Multidrug resistance-associated protein 4 Recombinant
 Multidrug resistance-associated protein 4 Antibody
Also known as Multidrug resistance-associated protein 4 (ATP-binding cassette sub-family C member 4) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B).
ABCC4: a widely-expressed multi-pass membrane protein. An organic anion pump involved in cellular detoxification. Widely expressed, with particularly high levels in prostate, but is barely detectable in li
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ver.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 13q32

Cellular Component: basolateral plasma membrane; membrane; plasma membrane; platelet dense granule membrane

Molecular Function: anion transmembrane-transporting ATPase activity; ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

Biological Process: platelet degranulation; prostaglandin secretion; transmembrane transport
 ABCC4 ELISA Kit
 ABCC4 Recombinant
 ABCC4 Antibody
 MRP4 ELISA Kit
 MRP4 Recombinant
 MRP4 Antibody
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Multidrug resistance-associated protein 5

 Multidrug resistance-associated protein 5 ELISA Kit
 Multidrug resistance-associated protein 5 Recombinant
 Multidrug resistance-associated protein 5 Antibody
Also known as Multidrug resistance-associated protein 5 (ATP-binding cassette sub-family C member 5).
ATP-binding cassette (ABC) multiple drug resistance protein that mediates efflux cGMP during nitric oxide-induced regulation of smooth muscle [RGD, Feb 2006]
 Abcc5 ELISA Kit
 Abcc5 Recombinant
 Abcc5 Antibody
 Abcc5a ELISA Kit
 Abcc5a Recombinant
 Abcc5a Antibody
 Mrp5 ELISA Kit
 Mrp5 Recombinant
 Mrp5 Antibody
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Multidrug resistance-associated protein 6

 Multidrug resistance-associated protein 6 ELISA Kit
 Multidrug resistance-associated protein 6 Recombinant
 Multidrug resistance-associated protein 6 Antibody
Also known as Multidrug resistance-associated protein 6 (ATP-binding cassette sub-family C member 6).
ABCC6: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS). Defects in ABCC6 are the cause of pseudoxanthoma elasti
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cum (PXE). PXE is a disorder characterized by calcification of elastic fibers in skin, arteries and retina that results in dermal lesions with associated laxity and loss of elasticity, arterial insufficiency and retinal hemorrhages leading to macular degeneration. PXE is caused in the overwhelming majority of cases by homozygous or compound heterozygous mutations in the ABCC6 gene (autosomal recessive PXE). Individuals carrying heterozygous mutations express limited manifestations of the pseudoxanthoma elasticum phenotype (autosomal dominant PXE). Defects in ABCC6 are the cause of arterial calcification of infancy, generalized, type 2 (GACI2). GACI2 is a severe autosomal recessive disorder characterized by calcification of the internal elastic lamina of muscular arteries and stenosis due to myointimal proliferation. The disorder is often fatal within the first 6 months of life because of myocardial ischemia resulting in refractory heart failure. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.

Protein type: Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Cellular Component: apical plasma membrane; lateral plasma membrane; membrane; nucleus; plasma membrane

Molecular Function: ATP binding; ATPase activity
 Abcc6 ELISA Kit
 Abcc6 Recombinant
 Abcc6 Antibody
 Mrp6 ELISA Kit
 Mrp6 Recombinant
 Mrp6 Antibody
Table BarTOPTable Bar
 

Multidrug resistance-associated protein 7

 Multidrug resistance-associated protein 7 ELISA Kit
 Multidrug resistance-associated protein 7 Recombinant
 Multidrug resistance-associated protein 7 Antibody
Also known as Multidrug resistance-associated protein 7 (ATP-binding cassette sub-family C member 10).
ABCC10: ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 2 isoforms of the human protein are produced by alternative splicing.
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br>Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Cellular Component: lysosomal membrane
 Abcc10 ELISA Kit
 Abcc10 Recombinant
 Abcc10 Antibody
 Mrp7 ELISA Kit
 Mrp7 Recombinant
 Mrp7 Antibody
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Multidrug resistance-associated protein 9

 Multidrug resistance-associated protein 9 ELISA Kit
 Multidrug resistance-associated protein 9 Recombinant
 Multidrug resistance-associated protein 9 Antibody
Also known as Multidrug resistance-associated protein 9 (ATP-binding cassette sub-family C member 12).
ABCC12: Probable transporter. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporte
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r; Transporter, ABC family

Cellular Component: mitochondrion
 Abcc12 ELISA Kit
 Abcc12 Recombinant
 Abcc12 Antibody
 Mrp9 ELISA Kit
 Mrp9 Recombinant
 Mrp9 Antibody
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