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Muscle, skeletal receptor tyrosine-protein kinase

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Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle .

Below are the list of possible Muscle, skeletal receptor tyrosine-protein kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Muscle, skeletal receptor tyrosine protein kinase

 Muscle, skeletal receptor tyrosine protein kinase ELISA Kit
 Muscle, skeletal receptor tyrosine protein kinase Recombinant
 Muscle, skeletal receptor tyrosine protein kinase Antibody
Also known as Muscle, skeletal receptor tyrosine protein kinase (Muscle-specific tyrosine protein kinase receptor) (MuSK) (Muscle-specific kinase receptor).
Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling c
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omplex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation ().
 MUSK ELISA Kit
 MUSK Recombinant
 MUSK Antibody
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Muscle, skeletal receptor tyrosine-protein kinase

 Muscle, skeletal receptor tyrosine-protein kinase ELISA Kit
 Muscle, skeletal receptor tyrosine-protein kinase Recombinant
 Muscle, skeletal receptor tyrosine-protein kinase Antibody
Also known as Muscle, skeletal receptor tyrosine-protein kinase (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor).
MUSK: a receptor tyrosine kinase that is essential for the establishment and maintenance of the neuromuscular junction (NMJ). Its activation by agrin, a neuronally derived heparan-sulfate proteoglycan, and the agrin receptor (LRP4), leads t
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o clustering of acetylcholine receptors on the postsynaptic side of the NMJ. Its activation by agrin requires Dok7, which interacts with the cytoplasmic portion of MuSK and activates its tyrosine kinase activity.

Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Musk family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Chromosomal Location of Human Ortholog: 9q31.3-q32

Cellular Component: integral to plasma membrane; neuromuscular junction; postsynaptic membrane; receptor complex

Molecular Function: protein binding; protein-tyrosine kinase activity

Biological Process: memory; neuromuscular junction development; positive regulation of protein amino acid phosphorylation; protein amino acid autophosphorylation; regulation of synaptic growth at neuromuscular junction; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Fetal Akinesia Deformation Sequence; Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency
 MUSK ELISA Kit
 MUSK Recombinant
 MUSK Antibody
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