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MyoD family inhibitor domain-containing protein

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Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways.

Below are the list of possible MyoD family inhibitor domain-containing protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

MyoD family inhibitor domain-containing protein

 MyoD family inhibitor domain-containing protein ELISA Kit
 MyoD family inhibitor domain-containing protein Recombinant
 MyoD family inhibitor domain-containing protein Antibody
Also known as MyoD family inhibitor domain-containing protein (I-mfa domain-containing protein) (hIC).
MDFIC: Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-de
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pendent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin- beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways. Belongs to the MDFI family. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Nucleolus

Chromosomal Location of Human Ortholog: 7q31.1-q31.2

Cellular Component: Golgi apparatus; nucleoplasm

Molecular Function: cyclin binding; protein binding; Tat protein binding; transcription factor binding

Biological Process: activation of JNK activity; negative regulation of protein import into nucleus; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of viral transcription; regulation of Wnt receptor signaling pathway
 MDFIC ELISA Kit
 MDFIC Recombinant
 MDFIC Antibody
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