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Myotubularin-related protein

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Dephosphorylates phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Negatively regulates accumulation of PI3P on intracellular vesicles .

Below are the list of possible Myotubularin-related protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Myotubularin-related protein 1

 Myotubularin-related protein 1 ELISA Kit
 Myotubularin-related protein 1 Recombinant
 Myotubularin-related protein 1 Antibody
Also known as Myotubularin-related protein 1 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase).
Dephosphorylates phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Negatively regulates accumulation of PI3P on intracellular vesicles (PubMed:19816564, PubMed:21490059). Negatively regulates phagocytosis
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of apoptotic cells probably by limiting the recruitment and/or the activation of ced-5, ced-2 and ced-12 complex (PubMed:19816564, PubMed:21490059). In addition, may positively regulate phagosome maturation by promoting recycling of apoptotic receptor ced-1 back to the plasma membrane (PubMed:21490059). Essential for embryonic and larval development (PubMed:19816564). May promote migration of distal tip cells (PubMed:19816564).
 mtm-1 ELISA Kit
 mtm-1 Recombinant
 mtm-1 Antibody
 Y110A7A.5 ELISA Kit
 Y110A7A.5 Recombinant
 Y110A7A.5 Antibody
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Myotubularin-related protein 10

 Myotubularin-related protein 10 ELISA Kit
 Myotubularin-related protein 10 Recombinant
 Myotubularin-related protein 10 Antibody
MTMR10: Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential). Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase
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, tyrosine (non-receptor)
 Mtmr10 ELISA Kit
 Mtmr10 Recombinant
 Mtmr10 Antibody
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Myotubularin-related protein 10-A

 Myotubularin-related protein 10-A ELISA Kit
 Myotubularin-related protein 10-A Recombinant
 Myotubularin-related protein 10-A Antibody
Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential).
 mtmr10-a ELISA Kit
 mtmr10-a Recombinant
 mtmr10-a Antibody
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Myotubularin-related protein 10-B

 Myotubularin-related protein 10-B ELISA Kit
 Myotubularin-related protein 10-B Recombinant
 Myotubularin-related protein 10-B Antibody
Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential).
 mtmr10-b ELISA Kit
 mtmr10-b Recombinant
 mtmr10-b Antibody
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Myotubularin-related protein 11

 Myotubularin-related protein 11 ELISA Kit
 Myotubularin-related protein 11 Recombinant
 Myotubularin-related protein 11 Antibody
MTMR11: Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential). Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase
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, tyrosine (non-receptor)
 Mtmr11 ELISA Kit
 Mtmr11 Recombinant
 Mtmr11 Antibody
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Myotubularin-related protein 12

 Myotubularin-related protein 12 ELISA Kit
 Myotubularin-related protein 12 Recombinant
 Myotubularin-related protein 12 Antibody
MTMR12: Catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Protein phosphatase, tyrosine (non-rece
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ptor)
 Mtmr12 ELISA Kit
 Mtmr12 Recombinant
 Mtmr12 Antibody
 Kiaa1682 ELISA Kit
 Kiaa1682 Recombinant
 Kiaa1682 Antibody
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Myotubularin-related protein 13

 Myotubularin-related protein 13 ELISA Kit
 Myotubularin-related protein 13 Recombinant
 Myotubularin-related protein 13 Antibody
Also known as Myotubularin-related protein 13 (SET-binding factor 2).
Guanine nucleotide exchange factor (GEF) which may activate Rab small GTPases. May promote the exchange of GDP to GTP, converting inactive GDP-bound Rab into their active GTP-bound form ().
 sbf2 ELISA Kit
 sbf2 Recombinant
 sbf2 Antibody
 mtmr13 ELISA Kit
 mtmr13 Recombinant
 mtmr13 Antibody
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Myotubularin-related protein 14

 Myotubularin-related protein 14 ELISA Kit
 Myotubularin-related protein 14 Recombinant
 Myotubularin-related protein 14 Antibody
Also known as Myotubularin-related protein 14 (HCV NS5A-transactivated protein 4 splice variant A-binding protein 1) (NS5ATP4ABP1) (hJumpy).
MTMR14: Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3. Expressed in various tissues, including heart, skeletal
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muscle, placenta, liver, lung, kidney and pancreas. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.-; Phosphatase, lipid; Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 3p26

Cellular Component: cytosol; perinuclear region of cytoplasm; ruffle

Molecular Function: phosphatidylinositol-3-phosphatase activity; protein binding; protein serine/threonine phosphatase activity

Biological Process: macroautophagy; phosphatidylinositol biosynthetic process

Disease: Myopathy, Centronuclear, 1
 MTMR14 ELISA Kit
 MTMR14 Recombinant
 MTMR14 Antibody
 C3orf29 ELISA Kit
 C3orf29 Recombinant
 C3orf29 Antibody
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Myotubularin-related protein 2

 Myotubularin-related protein 2 ELISA Kit
 Myotubularin-related protein 2 Recombinant
 Myotubularin-related protein 2 Antibody
Also known as Myotubularin-related protein 2 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase).
Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate ().
 MTMR2 ELISA Kit
 MTMR2 Recombinant
 MTMR2 Antibody
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Myotubularin-related protein 3

 Myotubularin-related protein 3 ELISA Kit
 Myotubularin-related protein 3 Recombinant
 Myotubularin-related protein 3 Antibody
Also known as Myotubularin-related protein 3 (ceMTM3) (Myotubularin homologous protein 1) (ceMTMH1) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase).
Preferentially dephosphorylates phosphatidylinositol 3-phosphate (PI3P), and has some activity towards phosphatidylinositol 3,5-bisphosphate (PI35P). May also dephosphorylate proteins phosphoryla
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ted on Ser, Thr, and Tyr residues (). Thought to have a role in maintenance of muscle function. Involved in locomotion and lifespan determination.
 mtm-3 ELISA Kit
 mtm-3 Recombinant
 mtm-3 Antibody
 T24A11.1 ELISA Kit
 T24A11.1 Recombinant
 T24A11.1 Antibody
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Myotubularin-related protein 4

 Myotubularin-related protein 4 ELISA Kit
 Myotubularin-related protein 4 Recombinant
 Myotubularin-related protein 4 Antibody
Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3) ().
 mtmr4 ELISA Kit
 mtmr4 Recombinant
 mtmr4 Antibody
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Myotubularin-related protein 5

 Myotubularin-related protein 5 ELISA Kit
 Myotubularin-related protein 5 Recombinant
 Myotubularin-related protein 5 Antibody
Probable pseudophosphatase. Contains a Leu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase.
 mtm-5 ELISA Kit
 mtm-5 Recombinant
 mtm-5 Antibody
 H28G03.6 ELISA Kit
 H28G03.6 Recombinant
 H28G03.6 Antibody
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Myotubularin-related protein 6

 Myotubularin-related protein 6 ELISA Kit
 Myotubularin-related protein 6 Recombinant
 Myotubularin-related protein 6 Antibody
MTMR6: Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 2 isofo
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rms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - fructose and mannose; Cofactor and Vitamin Metabolism - riboflavin; Cofactor and Vitamin Metabolism - thiamine; EC 3.1.3.-; Phosphatase, lipid; Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 13q12

Cellular Component: cytoplasm; cytosol

Molecular Function: calcium-activated potassium channel activity; phosphatidylinositol-3-phosphatase activity; protein binding

Biological Process: phosphatidylinositol biosynthetic process
 MTMR6 ELISA Kit
 MTMR6 Recombinant
 MTMR6 Antibody
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Myotubularin-related protein 7

 Myotubularin-related protein 7 ELISA Kit
 Myotubularin-related protein 7 Recombinant
 Myotubularin-related protein 7 Antibody
MTMR7: a protein of the myotubularin family. Myotubularins are a family of unique protein tyrosine phosphatases that utilize inositol phospholipids, rather than phosphoproteins, as physiological substrates. Myotubularins specifically dephosphorylate phosphatidylinositol 3-phosphate [PI(3)P] and phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2], generating phosphatidylinositol and phosphatidylinos
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itol 5-phosphate [PI(5)P], respectively. PI(3)P and PI(3,5)P2 regulate membrane trafficking events through the recruitment of effector proteins containing the lipid-binding domains FYVE, PH, and ENTH. MTMR5, -9, -10, -11, -12, -13 are catalytically inactive lipid phosphatases but may mediate important protein-protein interactions. Expressed at high levels in the brain. Two alternatively spliced human isoforms have been described.

Protein type: EC 3.1.3.-; Motility/polarity/chemotaxis; Phosphatase, lipid; Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: cytosol

Molecular Function: phosphatidylinositol-3-phosphatase activity; protein binding

Biological Process: phosphatidylinositol biosynthetic process; protein amino acid dephosphorylation
 MTMR7 ELISA Kit
 MTMR7 Recombinant
 MTMR7 Antibody
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Myotubularin-related protein 8

 Myotubularin-related protein 8 ELISA Kit
 Myotubularin-related protein 8 Recombinant
 Myotubularin-related protein 8 Antibody
MTMR8: Phosphatase that acts on lipids with a phosphoinositol headgroup (Probable). Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.-; Phosphatase, lipid; Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: Xq11.2
 MTMR8 ELISA Kit
 MTMR8 Recombinant
 MTMR8 Antibody
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Myotubularin-related protein 9

 Myotubularin-related protein 9 ELISA Kit
 Myotubularin-related protein 9 Recombinant
 Myotubularin-related protein 9 Antibody
Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Probable). May act as a regulatory subunit for mtm-6. In association with phosphatase mtm-6, plays a role in endosome trafficking probably by regulating phosphatidylinositol-3-phosphate levels (PubMed:14565969). Regulates fluid phase endocytosis in coelomocytes (PubMed:14565969). Regulates posterior migration of QL neuroblast descendants and the anterior migration of QR neuroblast descendants and HSN neurons during larval
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development probably by controlling Wnt ligand secretion through the regulation of sorting receptor mig-14 trafficking (PubMed:21076391). Involved in the formation of correct synapse number in DA9 motor neurons (PubMed:25479419).
 mtm-9 ELISA Kit
 mtm-9 Recombinant
 mtm-9 Antibody
 cup-10 ELISA Kit
 cup-10 Recombinant
 cup-10 Antibody
 Y39H10A.3 ELISA Kit
 Y39H10A.3 Recombinant
 Y39H10A.3 Antibody
Table BarTOPTable Bar
 

Myotubularin-related protein DDB_G0290005

 Myotubularin-related protein DDB_G0290005 ELISA Kit
 Myotubularin-related protein DDB_G0290005 Recombinant
 Myotubularin-related protein DDB_G0290005 Antibody
Phosphatase that acts on lipids with a phosphoinositol headgroup.
 DDB_G0290005 ELISA Kit
 DDB_G0290005 Recombinant
 DDB_G0290005 Antibody
Table BarTOPTable Bar
Proteins Root Name Listing
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