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N-lysine methyltransferase

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Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.

Below are the list of possible N-lysine methyltransferase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

N-lysine methyltransferase KMT5A

 N-lysine methyltransferase KMT5A ELISA Kit
 N-lysine methyltransferase KMT5A Recombinant
 N-lysine methyltransferase KMT5A Antibody
Also known as N-lysine methyltransferase KMT5A (H4-K20-HMTase KMT5A) (Histone-lysine N-methyltransferase KMT5A) (Lysine N-methyltransferase 5A) (Lysine-specific methylase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET dom.
SETD8: a protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Methylates K20 of histone H4 (H4K20me1), a specific tag for epigenetic transcriptional repression. SETD8 protein and H4K20me1 levels are cell cycle regulated, both increasing in S phase and peaking at G2/M phase. Interacts with the PCNA protein, ass
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ociates with sites of active DNA synthesis and is required for DNA replication and genome stability during S phase. Inhibition of SET8 using shRNA results in arrest of replication forks, induction of double-stranded DNA breaks and a Chk1-mediated cell-cycle arrest in S and G2/M phases of the cell cycle. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Inhibition of SET8 using shRNA results in arrest of replication forks, induction of double-stranded DNA breaks and a Chk1-mediated cell-cycle arrest in S and G2/M phases of the cell cycle. Nucleosomes are preferred as substrate compared to free histones. Methylates p53K382, leading to repression of the pro-apoptotic and checkpoint activation functions of p53. SET8 expression levels decrease in response to DNA damage, allowing p53 to activate checkpoints and/or apoptosis. Both the methylation of histone H4K20 and p53K382 appear to be important for the functions of SET8 in S phase. Belongs to the histone-lysine methyltransferase family. PR/SET subfamily. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: histone lysine N-methyltransferase activity (H4-K20 specific); histone-lysine N-methyltransferase activity; lysine N-methyltransferase activity; p53 binding; protein binding; protein-lysine N-methyltransferase activity; transcription corepressor activity

Biological Process: negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; peptidyl-lysine mono-methylation; regulation of DNA damage response, signal transduction by p53 class mediator
 KMT5A ELISA Kit
 KMT5A Recombinant
 KMT5A Antibody
 PRSET7 ELISA Kit
 PRSET7 Recombinant
 PRSET7 Antibody
 SET07 ELISA Kit
 SET07 Recombinant
 SET07 Antibody
 SET8 ELISA Kit
 SET8 Recombinant
 SET8 Antibody
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N-lysine methyltransferase KMT5A-A

 N-lysine methyltransferase KMT5A-A ELISA Kit
 N-lysine methyltransferase KMT5A-A Recombinant
 N-lysine methyltransferase KMT5A-A Antibody
Also known as N-lysine methyltransferase KMT5A-A (Histone-lysine N-methyltransferase KMT5A-A) (Lysine-specific methylase 5A-A) (SET domain-containing protein 8-A).
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epige
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netic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis ().
 kmt5a-a ELISA Kit
 kmt5a-a Recombinant
 kmt5a-a Antibody
 setd8-a ELISA Kit
 setd8-a Recombinant
 setd8-a Antibody
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N-lysine methyltransferase KMT5A-B

 N-lysine methyltransferase KMT5A-B ELISA Kit
 N-lysine methyltransferase KMT5A-B Recombinant
 N-lysine methyltransferase KMT5A-B Antibody
Also known as N-lysine methyltransferase KMT5A-B (Histone-lysine N-methyltransferase KMT5A-B) (Lysine-specific methylase 5A-B) (Mitotic phosphoprotein 36) (SET domain-containing protein 8-B).
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell prolifera
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tion, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis ().
 kmt5a-b ELISA Kit
 kmt5a-b Recombinant
 kmt5a-b Antibody
 mp36 ELISA Kit
 mp36 Recombinant
 mp36 Antibody
 setd8-b ELISA Kit
 setd8-b Recombinant
 setd8-b Antibody
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N-lysine methyltransferase SETD6

 N-lysine methyltransferase SETD6 ELISA Kit
 N-lysine methyltransferase SETD6 Recombinant
 N-lysine methyltransferase SETD6 Antibody
Also known as N-lysine methyltransferase SETD6 (SET domain-containing protein 6).
SETD6: Protein-lysine N-methyltransferase that specifically monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. Belongs to the SETD6 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type:
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EC 2.1.1.-; Methyltransferase; Methyltransferase, protein lysine

Cellular Component: cytoplasm; nucleus

Molecular Function: NF-kappaB binding; protein-lysine N-methyltransferase activity

Biological Process: inhibition of NF-kappaB transcription factor; peptidyl-lysine mono-methylation; regulation of inflammatory response; stem cell differentiation; stem cell maintenance
 Setd6 ELISA Kit
 Setd6 Recombinant
 Setd6 Antibody
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N-lysine methyltransferase SMYD2

 N-lysine methyltransferase SMYD2 ELISA Kit
 N-lysine methyltransferase SMYD2 Recombinant
 N-lysine methyltransferase SMYD2 Antibody
Also known as N-lysine methyltransferase SMYD2 (Histone methyltransferase SMYD2) (SET and MYND domain-containing protein 2).
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/
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TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860' ().
 SMYD2 ELISA Kit
 SMYD2 Recombinant
 SMYD2 Antibody
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N-lysine methyltransferase SMYD2-A

 N-lysine methyltransferase SMYD2-A ELISA Kit
 N-lysine methyltransferase SMYD2-A Recombinant
 N-lysine methyltransferase SMYD2-A Antibody
Also known as N-lysine methyltransferase SMYD2-A (Histone methyltransferase SMYD2-A) (SET and MYND domain-containing protein 2A).
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on
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p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860' ().
 smyd2-a ELISA Kit
 smyd2-a Recombinant
 smyd2-a Antibody
 smyd2 ELISA Kit
 smyd2 Recombinant
 smyd2 Antibody
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N-lysine methyltransferase SMYD2-B

 N-lysine methyltransferase SMYD2-B ELISA Kit
 N-lysine methyltransferase SMYD2-B Recombinant
 N-lysine methyltransferase SMYD2-B Antibody
Also known as N-lysine methyltransferase SMYD2-B (Histone methyltransferase SMYD2-B) (SET and MYND domain-containing protein 2B).
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on
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p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860' ().
 smyd2b ELISA Kit
 smyd2b Recombinant
 smyd2b Antibody
 si:dkey-121j17.3 ELISA Kit
 si:dkey-121j17.3 Recombinant
 si:dkey-121j17.3 Antibody
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Proteins Root Name Listing
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