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Na(+)/H(+) exchange regulatory cofactor

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Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules (By similarity).

Below are the list of possible Na(+)/H(+) exchange regulatory cofactor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Na(+)/H(+) exchange regulatory cofactor NHE-RF1

 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 ELISA Kit
 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 Recombinant
 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 Antibody
Also known as Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1).
NHERF: a scaffold protein that connects plasma membrane proteins with members of the Ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized beta-2-adrenergic receptor Was first known to play a role in the
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regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Cellular Component: apical part of cell; apical plasma membrane; brush border membrane; centrosome; cytoplasm; intracellular membrane-bound organelle; lipid raft; membrane; microvillus; microvillus membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; stereocilium; stereocilium bundle tip; vesicle

Molecular Function: beta-2 adrenergic receptor binding; beta-catenin binding; chloride channel regulator activity; dopamine receptor binding; PDZ domain binding; phosphatase binding; protein binding; protein complex binding; protein complex scaffold; protein domain specific binding; protein self-association; receptor binding

Biological Process: actin cytoskeleton organization and biogenesis; auditory receptor cell stereocilium organization and biogenesis; bile acid secretion; cAMP-mediated signaling; cellular phosphate ion homeostasis; dopamine receptor, adenylate cyclase activating pathway; dopamine receptor, phospholipase C activating pathway; establishment of epithelial cell polarity; establishment of Golgi localization; establishment of nucleus localization; gland morphogenesis; microvillus biogenesis; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of mitotic cell cycle; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of protein kinase B signaling cascade; negative regulation of sodium:hydrogen antiporter activity; regulation of cell shape; regulation of cell size; regulation of protein kinase activity; renal sodium ion transport; sensory perception of sound
 Slc9a3r1 ELISA Kit
 Slc9a3r1 Recombinant
 Slc9a3r1 Antibody
 Nherf ELISA Kit
 Nherf Recombinant
 Nherf Antibody
 Nherf1 ELISA Kit
 Nherf1 Recombinant
 Nherf1 Antibody
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Na(+)/H(+) exchange regulatory cofactor NHE-RF2

 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 ELISA Kit
 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 Recombinant
 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 Antibody
Also known as Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (Octs2) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1).
NHERF-2: Scaffold protein that connects plasma membrane proteins with members of the ez
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rin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus. Homodimer, and heterodimer with SLC9A3R1. Binds PDZK1. Found in a complex with EZR, PODXL and SLC9A3R2. Interacts (via the PDZ domains) with PODXL (via the C-terminal PDZ-binding motif DTHL); interaction is detected in glomerular epithelium cells. Binds ADRB2, SLC9A3, P2RY1, P2YR2, SRY, RDX and LPAR2. Interacts with MCC and PODXL. Interacts with SGK1 and KCNJ1/ROMK1. Widely expressed. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Cellular Component: apical plasma membrane; cell-cell adherens junction; cytoplasm; focal adhesion; nucleus; plasma membrane; protein complex; stereocilium; stereocilium bundle

Molecular Function: beta-catenin binding; channel regulator activity; low-density lipoprotein receptor binding; PDZ domain binding; phosphatase binding; protein binding; protein C-terminus binding; protein complex scaffold; receptor binding

Biological Process: negative regulation of phosphoinositide 3-kinase cascade; positive regulation of membrane potential; sensory perception of sound
 Slc9a3r2 ELISA Kit
 Slc9a3r2 Recombinant
 Slc9a3r2 Antibody
 Nherf2 ELISA Kit
 Nherf2 Recombinant
 Nherf2 Antibody
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Na(+)/H(+) exchange regulatory cofactor NHE-RF3

 Na(+)/H(+) exchange regulatory cofactor NHE-RF3 ELISA Kit
 Na(+)/H(+) exchange regulatory cofactor NHE-RF3 Recombinant
 Na(+)/H(+) exchange regulatory cofactor NHE-RF3 Antibody
Also known as Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3).
PDZK1: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In co
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mplex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function. Belongs to the NHER family.

Protein type: Adaptor/scaffold

Cellular Component: apical plasma membrane; brush border membrane; lipid raft; microvillus membrane; plasma membrane

Molecular Function: PDZ domain binding; protein binding; protein complex binding; scavenger receptor binding

Biological Process: carnitine transport; transport
 Pdzk1 ELISA Kit
 Pdzk1 Recombinant
 Pdzk1 Antibody
 Cap70 ELISA Kit
 Cap70 Recombinant
 Cap70 Antibody
 Nherf3 ELISA Kit
 Nherf3 Recombinant
 Nherf3 Antibody
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Na(+)/H(+) exchange regulatory cofactor NHE-RF4

 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 ELISA Kit
 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 Recombinant
 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 Antibody
Also known as Na(+)/H(+) exchange regulatory cofactor NHE-RF4 (NHERF-4) (Intestinal and kidney-enriched PDZ protein) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (Na/Pi cotransporter C-terminal-associated protein 2) (NaPi-Cap2) (PDZ domain-containing protein 2) (PDZ domain-containing protein 3) (Sodium-hydrogen exchanger regulatory factor 4).
PDZD3: Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions. 5 isoforms of the hu
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man protein are produced by alternative splicing.

Protein type: Cell adhesion

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: apical part of cell; brush border; cytosol; subapical complex

Molecular Function: guanylate cyclase inhibitor activity; ion channel inhibitor activity; protein binding; protein C-terminus binding

Biological Process: negative regulation of cGMP biosynthetic process; receptor guanylyl cyclase signaling pathway; response to toxin
 PDZD3 ELISA Kit
 PDZD3 Recombinant
 PDZD3 Antibody
 IKEPP ELISA Kit
 IKEPP Recombinant
 IKEPP Antibody
 NHERF4 ELISA Kit
 NHERF4 Recombinant
 NHERF4 Antibody
 PDZK2 ELISA Kit
 PDZK2 Recombinant
 PDZK2 Antibody
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Proteins Root Name Listing
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