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NACHT, LRR and PYD domains-containing protein

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As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death .

Below are the list of possible NACHT, LRR and PYD domains-containing protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

NACHT, LRR and PYD domains-containing protein 1

 NACHT, LRR and PYD domains-containing protein 1 ELISA Kit
 NACHT, LRR and PYD domains-containing protein 1 Recombinant
 NACHT, LRR and PYD domains-containing protein 1 Antibody
Also known as NACHT, LRR and PYD domains-containing protein 1 (Caspase recruitment domain-containing protein 7) (Death effector filament-forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain).
This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with cas
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pase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
 NLRP1 ELISA Kit
 NLRP1 Recombinant
 NLRP1 Antibody
 CARD7 ELISA Kit
 CARD7 Recombinant
 CARD7 Antibody
 DEFCAP ELISA Kit
 DEFCAP Recombinant
 DEFCAP Antibody
 KIAA0926 ELISA Kit
 KIAA0926 Recombinant
 KIAA0926 Antibody
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NACHT, LRR and PYD domains-containing protein 10

 NACHT, LRR and PYD domains-containing protein 10 ELISA Kit
 NACHT, LRR and PYD domains-containing protein 10 Recombinant
 NACHT, LRR and PYD domains-containing protein 10 Antibody
NALP10: Inhibits CASP1/caspase-1-dependent IL1B secretion and PYCARD-mediated apoptosis, but not that induced by FAS or BID. Belongs to the NLRP family.

Protein type: Unknown function

Cellular Component: cytoplasm; extrinsic to plasma membrane

Biological Process: defense response; defense response to fungus; defense response to Gram-negative bacterium; positive regulation of T-helper 1 type immune response
 Nlrp10 ELISA Kit
 Nlrp10 Recombinant
 Nlrp10 Antibody
 Nalp10 ELISA Kit
 Nalp10 Recombinant
 Nalp10 Antibody
 Pynod ELISA Kit
 Pynod Recombinant
 Pynod Antibody
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NACHT, LRR and PYD domains-containing protein 11

 NACHT, LRR and PYD domains-containing protein 11 ELISA Kit
 NACHT, LRR and PYD domains-containing protein 11 Recombinant
 NACHT, LRR and PYD domains-containing protein 11 Antibody
Also known as NACHT, LRR and PYD domains-containing protein 11 (Nucleotide-binding oligomerization domain protein 17) (PAAD-and NACHT domain-containing protein 10) (PYRIN-containing APAF1-like protein 6).
NLRP11: Involved in inflammation (Potential). Belongs to the NLRP family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19q13.43
 NLRP11 ELISA Kit
 NLRP11 Recombinant
 NLRP11 Antibody
 NALP11 ELISA Kit
 NALP11 Recombinant
 NALP11 Antibody
 NOD17 ELISA Kit
 NOD17 Recombinant
 NOD17 Antibody
 PAN10 ELISA Kit
 PAN10 Recombinant
 PAN10 Antibody
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NACHT, LRR and PYD domains-containing protein 12

 NACHT, LRR and PYD domains-containing protein 12 ELISA Kit
 NACHT, LRR and PYD domains-containing protein 12 Recombinant
 NACHT, LRR and PYD domains-containing protein 12 Antibody
Also known as NACHT, LRR and PYD domains-containing protein 12 (Monarch-1) (PYRIN-containing APAF1-like protein 7) (PYPAF7).
NLRP12: May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK. Defects in NLRP12 are the cause of familial cold autoinflammatory syndrome type 2 (FCAS2). FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episod
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es of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold. Belongs to the NLRP family. 5 isoforms of the human protein are produced by alternative splicing.

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: inhibition of NF-kappaB transcription factor; negative regulation of cytokine secretion; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of inflammatory response; negative regulation of interleukin-1 secretion; negative regulation of interleukin-6 biosynthetic process; negative regulation of protein amino acid autophosphorylation; negative regulation of signal transduction; negative regulation of Toll signaling pathway; positive regulation of MHC class I biosynthetic process; regulation of caspase activity; regulation of I-kappaB kinase/NF-kappaB cascade; release of cytoplasmic sequestered NF-kappaB
 Nlrp12 ELISA Kit
 Nlrp12 Recombinant
 Nlrp12 Antibody
 NALP12 ELISA Kit
 NALP12 Recombinant
 NALP12 Antibody
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NACHT, LRR and PYD domains-containing protein 13

 NACHT, LRR and PYD domains-containing protein 13 ELISA Kit
 NACHT, LRR and PYD domains-containing protein 13 Recombinant
 NACHT, LRR and PYD domains-containing protein 13 Antibody
Also known as NACHT, LRR and PYD domains-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).
NLRP13: Involved in inflammation (Potential). Belongs to the NLRP family.

Chromosomal Location of Human Ortholog: 19q13.43
 NLRP13 ELISA Kit
 NLRP13 Recombinant
 NLRP13 Antibody
 NALP13 ELISA Kit
 NALP13 Recombinant
 NALP13 Antibody
 NOD14 ELISA Kit
 NOD14 Recombinant
 NOD14 Antibody
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NACHT, LRR and PYD domains-containing protein 14

 NACHT, LRR and PYD domains-containing protein 14 ELISA Kit
 NACHT, LRR and PYD domains-containing protein 14 Recombinant
 NACHT, LRR and PYD domains-containing protein 14 Antibody
Also known as NACHT, LRR and PYD domains-containing protein 14 (NALP-iota) (Germ cell specific leucine-rich repeat NTPase).
NLRP14: May be involved in inflammation and spermatogenesis. Belongs to the NLRP family.

Biological Process: spermatogenesis
 Nlrp14 ELISA Kit
 Nlrp14 Recombinant
 Nlrp14 Antibody
 Nalp14 ELISA Kit
 Nalp14 Recombinant
 Nalp14 Antibody
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NACHT, LRR and PYD domains-containing protein 1a

 NACHT, LRR and PYD domains-containing protein 1a ELISA Kit
 NACHT, LRR and PYD domains-containing protein 1a Recombinant
 NACHT, LRR and PYD domains-containing protein 1a Antibody
Also known as NACHT, LRR and PYD domains-containing protein 1a (Caspase recruitment domain-containing protein 7) (Death effector filament-forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain).
NALP1: Able to form cytoplasmic structures termed death effector filaments. Enhances APAF1 and cytochrome c-dependent activation of pro-caspase-9 and consecutive apoptosis. Stimulates apoptosis through activation of caspase-3. Involved in activation of caspase-1 and caspase-5 as part of the NALP1 inflammasome complex which leads to processing and release of I
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L1B and IL18. Binds ATP. Interacts strongly with caspase-2, weakly with caspase-9 and with APAF1 in a cytochrome c-inducible way, leading to the formation of an apoptosome. This interaction may be ATP-dependent. Part of the NALP1 inflammasome complex which is involved in activation of caspase-1 and caspase-5, leading to processing of IL1B and IL18. The complex is activated by bacterial muramyl dipeptide which triggers ATP-binding and oligomerization of NALP1. Widely expressed. Isoform 1 and isoform 2 are expressed in peripheral blood leukocytes and chronic myelogenous leukemia cell line K-562, followed by thymus, spleen and heart. Also detected in brain, lung, placenta, small intestine, colon, kidney, liver, muscle, testis and epithelial cells. Absent from hematopoietic progenitor cells but expressed upon differentiation of cells into granulocytes and, to a lesser extent, monocytes. In peripheral blood cells, highest levels are found in T-lymphocytes, granulocytes and monocytes. Expression is significantly increased in bone marrow blast cells of some acute leukemia patients but not in solid tumors. Belongs to the NLRP family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis

Cellular Component: cell soma; protein complex

Molecular Function: protein binding

Biological Process: defense response to bacterium; positive regulation of interleukin-1 beta secretion; response to muramyl dipeptide
 Nlrp1a ELISA Kit
 Nlrp1a Recombinant
 Nlrp1a Antibody
 Card7 ELISA Kit
 Card7 Recombinant
 Card7 Antibody
 Nalp1 ELISA Kit
 Nalp1 Recombinant
 Nalp1 Antibody
 Nalp1a ELISA Kit
 Nalp1a Recombinant
 Nalp1a Antibody
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NACHT, LRR and PYD domains-containing protein 1b allele 1

 NACHT, LRR and PYD domains-containing protein 1b allele 1 ELISA Kit
 NACHT, LRR and PYD domains-containing protein 1b allele 1 Recombinant
 NACHT, LRR and PYD domains-containing protein 1b allele 1 Antibody
NL1B1: As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of Nlrp1b, CASP1, and possibly PYCARD. Recruitement of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation a
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nd secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (PubMed:19651869, PubMed:21170303, PubMed:22753929, PubMed:22536155, PubMed:23818853). Activated by cleavage by Bacillus anthracis lethal toxin (LT) endopeptidase component (PubMed:19124602, PubMed:19651869, PubMed:19949100, PubMed:22536155, PubMed:23818853,PubMed:24935976, PubMed:24492532). Activated by metabolic inhibitors, such as 2-deoxy-D-glucose and sodium azide, by nutrient deprivation and hypoxia, possibly due to a decrease in cytosolic ATP (PubMed:23230290, PubMed:24935976). Also activated by Toxoplasma gondii (PubMed:24218483). Not activated by muramyl dipeptide, nor by full-length bacterial peptidoglycan (PubMed:22753929). Primary mediator of macrophage susceptibility to LT. In response to Bacillus anthracis infection, macrophages and dendritic cells release IL1B and undergo pyroptosis, an inflammatory form of programmed cell death. This early inflammatory response to the toxin increases resistance to infection by B. anthracis spores.

Cellular Component: nucleus

Molecular Function: ATP binding; enzyme binding; protein domain specific binding

Biological Process: caspase activation; interleukin-1 alpha production; interleukin-1 beta production; neuron apoptosis; protein catabolic process
 Nlrp1b ELISA Kit
 Nlrp1b Recombinant
 Nlrp1b Antibody
 Nalp1b ELISA Kit
 Nalp1b Recombinant
 Nalp1b Antibody
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NACHT, LRR and PYD domains-containing protein 1b allele 2

 NACHT, LRR and PYD domains-containing protein 1b allele 2 ELISA Kit
 NACHT, LRR and PYD domains-containing protein 1b allele 2 Recombinant
 NACHT, LRR and PYD domains-containing protein 1b allele 2 Antibody
NL1B2:

Cellular Component: nucleus

Molecular Function: ATP binding; enzyme binding; protein domain specific binding

Biological Process: caspase activation; interleukin-1 alpha production; interleukin-1 beta production; neuron apoptosis; protein catabolic process
 Nlrp1b ELISA Kit
 Nlrp1b Recombinant
 Nlrp1b Antibody
 Nalp1b ELISA Kit
 Nalp1b Recombinant
 Nalp1b Antibody
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NACHT, LRR and PYD domains-containing protein 1b allele 3

 NACHT, LRR and PYD domains-containing protein 1b allele 3 ELISA Kit
 NACHT, LRR and PYD domains-containing protein 1b allele 3 Recombinant
 NACHT, LRR and PYD domains-containing protein 1b allele 3 Antibody
NL1B3: As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of Nlrp1b, CASP1, and possibly PYCARD. Recruitement of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation a
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nd secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (By similarity). Contrary to Nlrp1b allele 1, allele 3 is not activated by Bacillus anthracis lethal toxin, nor by metabolic inhibitors, such as 2-deoxy-D-glucose and sodium azide.

Cellular Component: nucleus

Molecular Function: ATP binding; enzyme binding; protein domain specific binding

Biological Process: caspase activation; interleukin-1 alpha production; interleukin-1 beta production; neuron apoptosis; protein catabolic process
 Nlrp1b ELISA Kit
 Nlrp1b Recombinant
 Nlrp1b Antibody
 Nalp1b ELISA Kit
 Nalp1b Recombinant
 Nalp1b Antibody
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NACHT, LRR and PYD domains-containing protein 1b allele 4

 NACHT, LRR and PYD domains-containing protein 1b allele 4 ELISA Kit
 NACHT, LRR and PYD domains-containing protein 1b allele 4 Recombinant
 NACHT, LRR and PYD domains-containing protein 1b allele 4 Antibody
NL1B4: As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of Nlrp1b, CASP1, and possibly PYCARD. Recruitement of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation a
>>>
nd secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (By similarity). Contrary to Nlrp1b allele 1, allele 4 is not activated by Bacillus anthracis lethal toxin and no other activation signal is reported (PubMed:16429160). In addition, allele 4 is missing a CARD domain, which has been shown in other alleles to be involved in the interaction with PYCARD, CASP1 and CASP11. It is thus unclear if this allele is able to promote inflammasome assembly.

Cellular Component: nucleus

Molecular Function: ATP binding; enzyme binding; protein domain specific binding

Biological Process: caspase activation; interleukin-1 alpha production; interleukin-1 beta production; neuron apoptosis; protein catabolic process
 Nlrp1b ELISA Kit
 Nlrp1b Recombinant
 Nlrp1b Antibody
 Nalp1b ELISA Kit
 Nalp1b Recombinant
 Nalp1b Antibody
Table BarTOPTable Bar
 

NACHT, LRR and PYD domains-containing protein 1b allele 5

 NACHT, LRR and PYD domains-containing protein 1b allele 5 ELISA Kit
 NACHT, LRR and PYD domains-containing protein 1b allele 5 Recombinant
 NACHT, LRR and PYD domains-containing protein 1b allele 5 Antibody
NL1B5: As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of Nlrp1b, CASP1, and possibly PYCARD. Recruitement of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation a
>>>
nd secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. Activated by cleavage by Bacillus anthracis lethal toxin (LT) endopeptidase component. Activated by metabolic inhibitors, such as 2-deoxy-D-glucose and sodium azide (PubMed:24935976). Not activated by muramyl dipeptide, nor by full-length bacterial peptidoglycan. Primary mediator of macrophage susceptibility to LT. In response to Bacillus anthracis infection, macrophages and dendritic cells release IL1B and undergo pyroptosis, an inflammatory form of programmed cell death. This early inflammatory response to the toxin increases resistance to infection by B. anthracis spores. Binds ATP.

Cellular Component: nucleus

Molecular Function: ATP binding; enzyme binding; protein domain specific binding

Biological Process: caspase activation; interleukin-1 alpha production; interleukin-1 beta production; neuron apoptosis; protein catabolic process
 Nlrp1b ELISA Kit
 Nlrp1b Recombinant
 Nlrp1b Antibody
 Nalp1b ELISA Kit
 Nalp1b Recombinant
 Nalp1b Antibody
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NACHT, LRR and PYD domains-containing protein 2

 NACHT, LRR and PYD domains-containing protein 2 ELISA Kit
 NACHT, LRR and PYD domains-containing protein 2 Recombinant
 NACHT, LRR and PYD domains-containing protein 2 Antibody
Also known as NACHT, LRR and PYD domains-containing protein 2 (Nucleotide-binding site protein 1) (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2).
NLRP2: Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinfla
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mmatory caspases. Belongs to the NLRP family. 4 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: cytoplasm; Golgi apparatus; intracellular membrane-bound organelle; nuclear chromosome, telomeric region

Molecular Function: protein binding; Pyrin domain binding

Biological Process: positive regulation of caspase activity; positive regulation of interleukin-1 beta secretion
 NLRP2 ELISA Kit
 NLRP2 Recombinant
 NLRP2 Antibody
 NALP2 ELISA Kit
 NALP2 Recombinant
 NALP2 Antibody
 NBS1 ELISA Kit
 NBS1 Recombinant
 NBS1 Antibody
 PAN1 ELISA Kit
 PAN1 Recombinant
 PAN1 Antibody
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NACHT, LRR and PYD domains-containing protein 3

 NACHT, LRR and PYD domains-containing protein 3 ELISA Kit
 NACHT, LRR and PYD domains-containing protein 3 Recombinant
 NACHT, LRR and PYD domains-containing protein 3 Antibody
As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the
>>>
extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. Under resting conditions, NLRP3 is autoinhibited. NLRP3 activation stimuli include extracellular ATP, reactive oxygen species, K+ efflux, crystals of monosodium urate or cholesterol, beta-amyloid fibers, environmental or industrial particles and nanoparticles, etc. However, it is unclear what constitutes the direct NLRP3 activator. Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth. During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription. Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3'. May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF.
 NLRP3 ELISA Kit
 NLRP3 Recombinant
 NLRP3 Antibody
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NACHT, LRR and PYD domains-containing protein 4

 NACHT, LRR and PYD domains-containing protein 4 ELISA Kit
 NACHT, LRR and PYD domains-containing protein 4 Recombinant
 NACHT, LRR and PYD domains-containing protein 4 Antibody
Also known as NACHT, LRR and PYD domains-containing protein 4 (Cancer/testis antigen 58) (CT58) (PAAD and NACHT-containing protein 2) (PAN2) (PYRIN and NACHT-containing protein 2) (PYRIN-containing APAF1-like protein 4) (PYPAF4) (Ribonuclease inhibitor 2).
NALP4: May be involved in inflammation. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Belongs to the NLRP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein
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type: Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: 19q13.43

Cellular Component: cytosol

Biological Process: regulation of interferon type I production
 NLRP4 ELISA Kit
 NLRP4 Recombinant
 NLRP4 Antibody
 NALP4 ELISA Kit
 NALP4 Recombinant
 NALP4 Antibody
 PAN2 ELISA Kit
 PAN2 Recombinant
 PAN2 Antibody
 PYPAF4 ELISA Kit
 PYPAF4 Recombinant
 PYPAF4 Antibody
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NACHT, LRR and PYD domains-containing protein 4A

 NACHT, LRR and PYD domains-containing protein 4A ELISA Kit
 NACHT, LRR and PYD domains-containing protein 4A Recombinant
 NACHT, LRR and PYD domains-containing protein 4A Antibody
Also known as NACHT, LRR and PYD domains-containing protein 4A (NALP-ita).
Nlrp4a: May be involved in inflammation. Belongs to the NLRP family.

Protein type: Unknown function

Biological Process: defense response
 Nlrp4a ELISA Kit
 Nlrp4a Recombinant
 Nlrp4a Antibody
 Nalp4a ELISA Kit
 Nalp4a Recombinant
 Nalp4a Antibody
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NACHT, LRR and PYD domains-containing protein 4B

 NACHT, LRR and PYD domains-containing protein 4B ELISA Kit
 NACHT, LRR and PYD domains-containing protein 4B Recombinant
 NACHT, LRR and PYD domains-containing protein 4B Antibody
Also known as NACHT, LRR and PYD domains-containing protein 4B (NALP-gamma).
Nlrp4b: May be involved in inflammation. Belongs to the NLRP family.
 Nlrp4b ELISA Kit
 Nlrp4b Recombinant
 Nlrp4b Antibody
 Nalp4b ELISA Kit
 Nalp4b Recombinant
 Nalp4b Antibody
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NACHT, LRR and PYD domains-containing protein 4C

 NACHT, LRR and PYD domains-containing protein 4C ELISA Kit
 NACHT, LRR and PYD domains-containing protein 4C Recombinant
 NACHT, LRR and PYD domains-containing protein 4C Antibody
Also known as NACHT, LRR and PYD domains-containing protein 4C (NALP-alpha).
NALP4: May be involved in inflammation. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Belongs to the NLRP family. 3 isoforms of the human protein are produced by alternative spli
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cing.

Protein type: Cancer Testis Antigen (CTA)
 Nlrp4c ELISA Kit
 Nlrp4c Recombinant
 Nlrp4c Antibody
 Nalp4c ELISA Kit
 Nalp4c Recombinant
 Nalp4c Antibody
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NACHT, LRR and PYD domains-containing protein 4E

 NACHT, LRR and PYD domains-containing protein 4E ELISA Kit
 NACHT, LRR and PYD domains-containing protein 4E Recombinant
 NACHT, LRR and PYD domains-containing protein 4E Antibody
Also known as NACHT, LRR and PYD domains-containing protein 4E (NALP-epsilon).
May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors.
 Nlrp4e ELISA Kit
 Nlrp4e Recombinant
 Nlrp4e Antibody
 Nalp4e ELISA Kit
 Nalp4e Recombinant
 Nalp4e Antibody
 Nlrp4 ELISA Kit
 Nlrp4 Recombinant
 Nlrp4 Antibody
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NACHT, LRR and PYD domains-containing protein 4F

 NACHT, LRR and PYD domains-containing protein 4F ELISA Kit
 NACHT, LRR and PYD domains-containing protein 4F Recombinant
 NACHT, LRR and PYD domains-containing protein 4F Antibody
Also known as NACHT, LRR and PYD domains-containing protein 4F (NALP-kappa).
May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors.
 Nlrp4f ELISA Kit
 Nlrp4f Recombinant
 Nlrp4f Antibody
 Nalp4f ELISA Kit
 Nalp4f Recombinant
 Nalp4f Antibody
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NACHT, LRR and PYD domains-containing protein 5

 NACHT, LRR and PYD domains-containing protein 5 ELISA Kit
 NACHT, LRR and PYD domains-containing protein 5 Recombinant
 NACHT, LRR and PYD domains-containing protein 5 Antibody
Also known as NACHT, LRR and PYD domains-containing protein 5 (Mater protein homolog).
NLRP5: As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions. Belongs to the NLRP family.

Protein type: Nucleolus

Chromosomal Location of Human Ortholog: 19q13.43

Cellular Component: mitochondrion; nucleolus
 NLRP5 ELISA Kit
 NLRP5 Recombinant
 NLRP5 Antibody
 MATER ELISA Kit
 MATER Recombinant
 MATER Antibody
 NALP5 ELISA Kit
 NALP5 Recombinant
 NALP5 Antibody
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NACHT, LRR and PYD domains-containing protein 6

 NACHT, LRR and PYD domains-containing protein 6 ELISA Kit
 NACHT, LRR and PYD domains-containing protein 6 Recombinant
 NACHT, LRR and PYD domains-containing protein 6 Antibody
Also known as NACHT, LRR and PYD domains-containing protein 6 (Angiotensin II/vasopressin receptor) (Non-angiotensin-vasopressin receptor) (Non-AVR) (PYRIN-containing APAF1-like protein 5-like).
NLRP6: May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic pot
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ential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation. Belongs to the NLRP family.

Protein type: Receptor, misc.

Molecular Function: peptide binding; vasopressin receptor activity

Biological Process: negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of immune response; negative regulation of inflammatory response to antigenic stimulus; negative regulation of MAPKKK cascade; negative regulation of toll-like receptor signaling pathway; regulation of autophagy; regulation of inflammatory response; response to bacterium; wound healing
 Nlrp6 ELISA Kit
 Nlrp6 Recombinant
 Nlrp6 Antibody
 Nalp6 ELISA Kit
 Nalp6 Recombinant
 Nalp6 Antibody
 Navr ELISA Kit
 Navr Recombinant
 Navr Antibody
 Pypaf5 ELISA Kit
 Pypaf5 Recombinant
 Pypaf5 Antibody
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NACHT, LRR and PYD domains-containing protein 7

 NACHT, LRR and PYD domains-containing protein 7 ELISA Kit
 NACHT, LRR and PYD domains-containing protein 7 Recombinant
 NACHT, LRR and PYD domains-containing protein 7 Antibody
Also known as NACHT, LRR and PYD domains-containing protein 7 (Nucleotide-binding oligomerization domain protein 12) (PYRIN-containing APAF1-like protein 3).
NLRP7: Inhibits CASP1/caspase-1-dependent IL1B secretion. Defects in NLRP7 are the cause of hydatidiform mole recurrent type 1 (HYDM1). A disorder characterized by excessive trophoblast development and the presence of a growing mass of tissue inside the uterus at the beginning of a pregnancy. It leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi. Belongs to the NLRP family. 3 isoforms of the hu
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man protein are produced by alternative splicing.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 19q13.42

Disease: Hydatidiform Mole, Recurrent, 1
 NLRP7 ELISA Kit
 NLRP7 Recombinant
 NLRP7 Antibody
 NALP7 ELISA Kit
 NALP7 Recombinant
 NALP7 Antibody
 NOD12 ELISA Kit
 NOD12 Recombinant
 NOD12 Antibody
 PYPAF3 ELISA Kit
 PYPAF3 Recombinant
 PYPAF3 Antibody
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NACHT, LRR and PYD domains-containing protein 8

 NACHT, LRR and PYD domains-containing protein 8 ELISA Kit
 NACHT, LRR and PYD domains-containing protein 8 Recombinant
 NACHT, LRR and PYD domains-containing protein 8 Antibody
Also known as NACHT, LRR and PYD domains-containing protein 8 (Nucleotide-binding oligomerization domain protein 16) (PYRIN and NACHT-containing protein 4).
NLRP8: Involved in inflammation (Potential). Belongs to the NLRP family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19q13.43
 NLRP8 ELISA Kit
 NLRP8 Recombinant
 NLRP8 Antibody
 NALP8 ELISA Kit
 NALP8 Recombinant
 NALP8 Antibody
 NOD16 ELISA Kit
 NOD16 Recombinant
 NOD16 Antibody
 PAN4 ELISA Kit
 PAN4 Recombinant
 PAN4 Antibody
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NACHT, LRR and PYD domains-containing protein 9

 NACHT, LRR and PYD domains-containing protein 9 ELISA Kit
 NACHT, LRR and PYD domains-containing protein 9 Recombinant
 NACHT, LRR and PYD domains-containing protein 9 Antibody
Involved in inflammation.
 NLRP9 ELISA Kit
 NLRP9 Recombinant
 NLRP9 Antibody
 NALP9 ELISA Kit
 NALP9 Recombinant
 NALP9 Antibody
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NACHT, LRR and PYD domains-containing protein 9A

 NACHT, LRR and PYD domains-containing protein 9A ELISA Kit
 NACHT, LRR and PYD domains-containing protein 9A Recombinant
 NACHT, LRR and PYD domains-containing protein 9A Antibody
Also known as NACHT, LRR and PYD domains-containing protein 9A (NALP-theta).
NLRP9A: Involved in inflammation (Potential)
 Nlrp9a ELISA Kit
 Nlrp9a Recombinant
 Nlrp9a Antibody
 Nalp9a ELISA Kit
 Nalp9a Recombinant
 Nalp9a Antibody
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NACHT, LRR and PYD domains-containing protein 9B

 NACHT, LRR and PYD domains-containing protein 9B ELISA Kit
 NACHT, LRR and PYD domains-containing protein 9B Recombinant
 NACHT, LRR and PYD domains-containing protein 9B Antibody
Also known as NACHT, LRR and PYD domains-containing protein 9B (NALP-delta).
NLRP9: Involved in inflammation (Potential). Belongs to the NLRP family. 2 isoforms of the human protein are produced by alternative splicing.
 Nlrp9b ELISA Kit
 Nlrp9b Recombinant
 Nlrp9b Antibody
 Nalp9 ELISA Kit
 Nalp9 Recombinant
 Nalp9 Antibody
 Nalp9b ELISA Kit
 Nalp9b Recombinant
 Nalp9b Antibody
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NACHT, LRR and PYD domains-containing protein 9C

 NACHT, LRR and PYD domains-containing protein 9C ELISA Kit
 NACHT, LRR and PYD domains-containing protein 9C Recombinant
 NACHT, LRR and PYD domains-containing protein 9C Antibody
Also known as NACHT, LRR and PYD domains-containing protein 9C (NALP-zeta).
Nlrp9c: Involved in inflammation (Potential). Belongs to the NLRP family. 2 isoforms of the human protein are produced by alternative splicing.
 Nlrp9c ELISA Kit
 Nlrp9c Recombinant
 Nlrp9c Antibody
 Nalp9c ELISA Kit
 Nalp9c Recombinant
 Nalp9c Antibody
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Proteins Root Name Listing
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