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Natural resistance-associated macrophage protein

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Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

Below are the list of possible Natural resistance-associated macrophage protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Natural resistance-associated macrophage protein 1

 Natural resistance-associated macrophage protein 1 ELISA Kit
 Natural resistance-associated macrophage protein 1 Recombinant
 Natural resistance-associated macrophage protein 1 Antibody
Also known as Natural resistance-associated macrophage protein 1 (NRAMP 1) (Solute carrier family 11 member 1).
SLC11A1: Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen
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species, but to deny the cations to the pathogen for synthesis of its protective enzymes. Belongs to the NRAMP family.

Protein type: Cell surface; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family; Vesicle

Cellular Component: cell surface; endosome membrane; late endosome; lysosome; phagocytic vesicle membrane; plasma membrane

Molecular Function: manganese ion transmembrane transporter activity; metal ion:hydrogen antiporter activity; protein homodimerization activity; transition metal ion transmembrane transporter activity

Biological Process: activation of protein kinase activity; antigen processing and presentation of peptide antigen; cellular cadmium ion homeostasis; cellular iron ion homeostasis; defense response to bacterium; defense response to Gram-negative bacterium; defense response to protozoan; inflammatory response; interleukin-2 production; interleukin-3 production; iron ion homeostasis; iron ion transport; L-arginine import; macrophage activation; manganese ion transport; MAPKKK cascade; MHC class II biosynthetic process; mRNA stabilization; negative regulation of cytokine production; nitrite transport; phagocytosis; positive regulation of cytokine production; positive regulation of dendritic cell antigen processing and presentation; positive regulation of interferon-gamma production; positive regulation of phagocytosis; positive regulation of T-helper 1 type immune response; positive regulation of transcription from RNA polymerase II promoter; protein import into nucleus, translocation; respiratory burst; response to bacterium; response to lipopolysaccharide; T cell cytokine production; T cell proliferation during immune response; vacuolar acidification; wound healing
 Slc11a1 ELISA Kit
 Slc11a1 Recombinant
 Slc11a1 Antibody
 Bcg ELISA Kit
 Bcg Recombinant
 Bcg Antibody
 Ity ELISA Kit
 Ity Recombinant
 Ity Antibody
 Lsh ELISA Kit
 Lsh Recombinant
 Lsh Antibody
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Natural resistance-associated macrophage protein 2

 Natural resistance-associated macrophage protein 2 ELISA Kit
 Natural resistance-associated macrophage protein 2 Recombinant
 Natural resistance-associated macrophage protein 2 Antibody
Also known as Natural resistance-associated macrophage protein 2 (NRAMP 2) (Divalent cation transporter 1) (Divalent metal transporter 1) (DMT-1) (Solute carrier family 11 member 2).
SLC11A2: Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. Defects in SLC11A2 are a cause of hy
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pochromic microcytic anemia (HCMA). The disease is characterized by an abnormal hemoglobin content in the erythrocytes which are reduced in size. It may be hereditary or acquired. Mutations in SLC11A2 are associated with progressive liver iron overload and normal to moderately elevated serum ferritin levels. Belongs to the NRAMP family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Cellular Component: apical part of cell; apical plasma membrane; brush border; brush border membrane; cell surface; cytoplasm; cytoplasmic vesicle; early endosome; endomembrane system; endosome; integral to membrane; integral to plasma membrane; late endosome membrane; lysosomal membrane; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; recycling endosome; vacuole

Molecular Function: cadmium ion binding; cadmium ion transmembrane transporter activity; cobalt ion binding; cobalt ion transmembrane transporter activity; copper ion binding; copper ion transmembrane transporter activity; ferrous iron transmembrane transporter activity; ferrous iron uptake transmembrane transporter activity; hydrogen ion transmembrane transporter activity; iron ion binding; iron ion transmembrane transporter activity; lead ion transmembrane transporter activity; manganese ion binding; manganese ion transmembrane transporter activity; nickel ion binding; nickel ion transmembrane transporter activity; solute:hydrogen symporter activity; transition metal ion transmembrane transporter activity; zinc ion binding

Biological Process: cellular copper ion homeostasis; cobalt ion transport; copper ion transport; dendrite morphogenesis; erythrocyte development; ferrous iron transport; heme biosynthetic process; iron ion transport; lead ion transport; learning and/or memory; manganese ion transport; porphyrin biosynthetic process; porphyrin metabolic process; proton transport; response to manganese ion; transition metal ion transport
 Slc11a2 ELISA Kit
 Slc11a2 Recombinant
 Slc11a2 Antibody
 Dct1 ELISA Kit
 Dct1 Recombinant
 Dct1 Antibody
 Dmt1 ELISA Kit
 Dmt1 Recombinant
 Dmt1 Antibody
 Nramp2 ELISA Kit
 Nramp2 Recombinant
 Nramp2 Antibody
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Natural resistance-associated macrophage protein 2 homolog

 Natural resistance-associated macrophage protein 2 homolog ELISA Kit
 Natural resistance-associated macrophage protein 2 homolog Recombinant
 Natural resistance-associated macrophage protein 2 homolog Antibody
Divalent transition metal (iron and manganese) transporter.
 nramp2 ELISA Kit
 nramp2 Recombinant
 nramp2 Antibody
 mntH ELISA Kit
 mntH Recombinant
 mntH Antibody
 DDB_G0275815 ELISA Kit
 DDB_G0275815 Recombinant
 DDB_G0275815 Antibody
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