| Necdin ELISA Kit|
|NDN: Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as trans |
cription factor and binds directly to specific guanosine-rich DNA sequences.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 15q11.2-q12
Biological Process: nervous system development
Disease: Prader-willi Syndrome
| NDN ELISA Kit|