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Nectin

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Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Has some neurite outgrowth-promoting activity.

Below are the list of possible Nectin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Nectin-1

 Nectin-1 ELISA Kit
 Nectin-1 Recombinant
 Nectin-1 Antibody
Also known as Nectin-1 (Herpes virus entry mediator C) (Herpesvirus entry mediator C) (HveC) (Herpesvirus Ig-like receptor) (HIgR) (Nectin cell adhesion molecule 1) (Poliovirus receptor-related protein 1) (CD antigen CD111).
nectin 1: Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Defects in PVRL1 are the cause of ectodermal dysplasia Margarita Island type (EDMI); also known as Zlotogora-Ogur syndrome, cleft lip/palate-ectoder
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mal dysplasia syndrome (CLPED1) or ectodermal dysplasia 4. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDMI is an autosomal recessive syndrome characterized by the association of cleft lip/palate, ectodermal dysplasia (sparse short and dry scalp hair, sparse eyebrows and eyelashes), and partial syndactyly of the fingers and/or toes. Two thirds of the patients do not manifest oral cleft but present with abnormal teeth and nails. Defects in PVRL1 are the cause of non-syndromic orofacial cleft type 7 (OFC7). Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two- third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. Belongs to the nectin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: cell-cell adherens junction; integral to plasma membrane; membrane; plasma membrane

Molecular Function: cell adhesion molecule binding; coreceptor activity; protein binding; protein homodimerization activity; receptor binding

Biological Process: cell recognition; heterophilic cell adhesion; homophilic cell adhesion

Disease: Cleft Lip/palate-ectodermal Dysplasia Syndrome
 NECTIN1 ELISA Kit
 NECTIN1 Recombinant
 NECTIN1 Antibody
 HVEC ELISA Kit
 HVEC Recombinant
 HVEC Antibody
 PRR1 ELISA Kit
 PRR1 Recombinant
 PRR1 Antibody
 PVRL1 ELISA Kit
 PVRL1 Recombinant
 PVRL1 Antibody
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Nectin-2

 Nectin-2 ELISA Kit
 Nectin-2 Recombinant
 Nectin-2 Antibody
Also known as Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Murine herpes virus entry protein B) (mHveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor homolog) (Poliovirus receptor-related protein 2) (CD antigen CD112).
nectin 2: Probable cell adhesion protein. Belongs to the nectin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Cellular Component: apical junction complex; cell surface; focal adhesion; integral to membrane; integral to plasma membra
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ne; intercellular junction; plasma membrane; zonula adherens

Molecular Function: cell adhesion molecule binding; protein binding; protein homodimerization activity; receptor activity; receptor binding

Biological Process: acrosome formation; adhesion to host; cell part morphogenesis; cell recognition; cytoskeleton organization and biogenesis; establishment of mitochondrion localization; fertilization; heterophilic cell adhesion; homophilic cell adhesion; positive regulation of immunoglobulin mediated immune response; positive regulation of mast cell activation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; regulation of virion penetration into host cell; sperm mitochondrion organization and biogenesis; spermatid development; spermatid nuclear differentiation; susceptibility to natural killer cell mediated cytotoxicity; viral envelope fusion with host membrane; virion attachment, binding of host cell surface coreceptor
 Nectin2 ELISA Kit
 Nectin2 Recombinant
 Nectin2 Antibody
 Mph ELISA Kit
 Mph Recombinant
 Mph Antibody
 Pvr ELISA Kit
 Pvr Recombinant
 Pvr Antibody
 Pvrl2 ELISA Kit
 Pvrl2 Recombinant
 Pvrl2 Antibody
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Nectin-3

 Nectin-3 ELISA Kit
 Nectin-3 Recombinant
 Nectin-3 Antibody
Also known as Nectin-3 (CDw113) (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3) (CD antigen CD113).
PVRL3: Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regu
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lation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. Belongs to the nectin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q13

Cellular Component: cell-cell adherens junction; integral to plasma membrane; plasma membrane

Molecular Function: cell adhesion molecule binding; protein binding; protein homodimerization activity; receptor activity; receptor binding

Biological Process: cell recognition; heterophilic cell adhesion; homophilic cell adhesion
 NECTIN3 ELISA Kit
 NECTIN3 Recombinant
 NECTIN3 Antibody
 PRR3 ELISA Kit
 PRR3 Recombinant
 PRR3 Antibody
 PVRL3 ELISA Kit
 PVRL3 Recombinant
 PVRL3 Antibody
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Nectin-4

 Nectin-4 ELISA Kit
 Nectin-4 Recombinant
 Nectin-4 Antibody
Also known as Nectin-4 (Ig superfamily receptor LNIR) (Nectin cell adhesion molecule 4) (Poliovirus receptor-related protein 4).
Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1.
 Nectin4 ELISA Kit
 Nectin4 Recombinant
 Nectin4 Antibody
 Lnir ELISA Kit
 Lnir Recombinant
 Lnir Antibody
 Prr4 ELISA Kit
 Prr4 Recombinant
 Prr4 Antibody
 Pvrl4 ELISA Kit
 Pvrl4 Recombinant
 Pvrl4 Antibody
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