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Nephrocystin

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Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells, together with NPHP4 and RPGRIP1L/NPHP8. Does not seem to be strictly required for ciliogenesis. Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis; required for the differentiation of early elongating spermatids into spermatozoa.

Below are the list of possible Nephrocystin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Nephrocystin-1

 Nephrocystin-1 ELISA Kit
 Nephrocystin-1 Recombinant
 Nephrocystin-1 Antibody
NPHP1: Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8. Does not seem to be strictly required for ciliogenesis. Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. Ma
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y play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis. Interacts with BCAR1, PTK2B/PYK2 and tensin. Interacts with INVS and NPHP3. Interacts with PACS1; the interaction is dependent on NPHP1 phosphorylation by CK2. Interatcs with KIF7. Interacts with AHI1 and TNK2. Interacts with NPHP4 in a complex containing NPHP1, NPHP4 and RPGRIP1L. Interacts with IQCB1; the interaction likely requires additional interactors. Widespread expression, with highest levels in pituitary gland, spinal cord, thyroid gland, testis, skeletal muscle, lymph node and trachea. Weakly expressed in heart, kidney and pancreas. Expressed in nasal epithelial cells. Belongs to the nephrocystin-1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion

Cellular Component: cytoplasm; intercellular junction; photoreceptor connecting cilium

Molecular Function: protein binding

Biological Process: cell projection organization and biogenesis; retina development in camera-type eye; spermatid differentiation
 Nphp1 ELISA Kit
 Nphp1 Recombinant
 Nphp1 Antibody
 Nph1 ELISA Kit
 Nph1 Recombinant
 Nph1 Antibody
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Nephrocystin-3

 Nephrocystin-3 ELISA Kit
 Nephrocystin-3 Recombinant
 Nephrocystin-3 Antibody
Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling that regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements ().
 nphp3 ELISA Kit
 nphp3 Recombinant
 nphp3 Antibody
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Nephrocystin-4

 Nephrocystin-4 ELISA Kit
 Nephrocystin-4 Recombinant
 Nephrocystin-4 Antibody
Involved in the organization of apical junctions (). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit int to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as daam1 (PubMed:26644512). May downregulate the canonical Wnt pathway and promote the Wnt-PCP
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pathway. Acts as negative regulator of the hippo pathway ().
 nphp4 ELISA Kit
 nphp4 Recombinant
 nphp4 Antibody
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