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Nesprin

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Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrososme attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 seem to act redundantly in cerebellum, midbrain, brain stem, and other brain regions except cerebral cortex and hippocampus. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenenis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.

Below are the list of possible Nesprin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Nesprin-1

 Nesprin-1 ELISA Kit
 Nesprin-1 Recombinant
 Nesprin-1 Antibody
Also known as Nesprin-1 (Enaptin) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1).
SYNE1: Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. Component of SUN-protein- containing multivariate complexes
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also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. May be involved in the maintenance of nuclear organization and structural integrity. Connects nuclei to the cytoskeleton by interacting with the nuclear envelope and with F- actin in the cytoplasm. May be required for centrosome migration to the apical cell surface during early ciliogenesis. Defects in SYNE1 are the cause of spinocerebellar ataxia autosomal recessive type 8 (SCAR8); also known as autosomal recessive cerebellar ataxia type 1 (ARCA1) or recessive ataxia of Beauce. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR8 is an autosomal recessive form. Defects in SYNE1 are the cause of Emery-Dreifuss muscular dystrophy type 4 (EDMD4). A degenerative myopathy characterized by weakness and atrophy of muscle without involvement of the nervous system, early contractures of the elbows, Achilles tendons and spine, and cardiomyopathy associated with cardiac conduction defects. Belongs to the nesprin family. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; Membrane protein, integral; RNA-binding

Cellular Component: cell; cytoplasm; dendritic spine; Golgi apparatus; integral to membrane; midbody; nuclear envelope; nuclear membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; postsynaptic membrane; sarcomere; spindle

Molecular Function: actin binding; actin filament binding; enzyme binding; lamin binding; protein binding; protein homodimerization activity; receptor binding

Biological Process: establishment of nucleus localization; Golgi organization and biogenesis; muscle cell differentiation; positive regulation of receptor-mediated endocytosis; regulation of dendrite morphogenesis
 Syne1 ELISA Kit
 Syne1 Recombinant
 Syne1 Antibody
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Nesprin-2

 Nesprin-2 ELISA Kit
 Nesprin-2 Recombinant
 Nesprin-2 Antibody
Also known as Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2).
SYNE2: a nuclear transmembrane protein involved in the maintenance of nuclear organization and structural integrity. The largest part of the protein is cytoplasmic, while its C-terminal part is associated with the nu
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clear envelope, most probably the outer nuclear membrane. Remains associated with the nuclear envelope during its breakdown in mitotic cells. Probable anchoring protein which theters the nucleus to the cytoskeleton. Connects nuclei to the cytoskeleton by interacting with the nuclear envelope and with F-actin in the cytoplasm. Nine alternatively spliced isoforms have been described.

Protein type: Adaptor/scaffold; Membrane protein, integral

Cellular Component: cell; cytoplasm; filopodium membrane; focal adhesion; intermediate filament cytoskeleton; mitochondrion; myofibril; nuclear envelope; nuclear lumen; nuclear membrane; nuclear outer membrane; nucleus; sarcoplasmic reticulum; Z disc

Molecular Function: actin binding

Biological Process: centrosome localization; establishment and/or maintenance of cell polarity; nuclear membrane organization and biogenesis; nuclear migration; nuclear migration along microfilament; positive regulation of cell migration
 Syne2 ELISA Kit
 Syne2 Recombinant
 Syne2 Antibody
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Nesprin-3

 Nesprin-3 ELISA Kit
 Nesprin-3 Recombinant
 Nesprin-3 Antibody
Also known as Nesprin-3 (Nuclear envelope spectrin repeat protein 3).
SYNE3: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring
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protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow- induced centrosome polarization and directional migration in aortic endothelial cells. Belongs to the nesprin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q32.13

Cellular Component: membrane; nuclear envelope

Molecular Function: actin filament binding; protein binding

Biological Process: cytoskeleton organization and biogenesis; regulation of cell shape
 SYNE3 ELISA Kit
 SYNE3 Recombinant
 SYNE3 Antibody
 C14orf49 ELISA Kit
 C14orf49 Recombinant
 C14orf49 Antibody
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Nesprin-4

 Nesprin-4 ELISA Kit
 Nesprin-4 Recombinant
 Nesprin-4 Antibody
Also known as Nesprin-4 (Nuclear envelope spectrin repeat protein 4).
AI428936: Contributes to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus. Belongs to the nesprin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Me
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mbrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.12

Cellular Component: cytoplasm

Molecular Function: protein binding

Biological Process: establishment of epithelial cell polarity; mitotic spindle organization and biogenesis

Disease: Deafness, Autosomal Recessive 76
 SYNE4 ELISA Kit
 SYNE4 Recombinant
 SYNE4 Antibody
 C19orf46 ELISA Kit
 C19orf46 Recombinant
 C19orf46 Antibody
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