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Netrin receptor

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Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

Below are the list of possible Netrin receptor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Netrin receptor DCC

 Netrin receptor DCC ELISA Kit
 Netrin receptor DCC Recombinant
 Netrin receptor DCC Antibody
Also known as Netrin receptor DCC (Colorectal cancer suppressor) (Immunoglobulin superfamily DCC subclass member 1) (Tumor suppressor protein DCC).
DCC: Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as
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a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. Defects in DCC are the cause of mirror movements type 1 (MRMV1). A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. Belongs to the immunoglobulin superfamily. DCC family.

Protein type: Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.; Tumor suppressor

Chromosomal Location of Human Ortholog: 18q21.3

Cellular Component: cytosol; plasma membrane

Molecular Function: protein binding; transmembrane receptor activity

Biological Process: apoptosis; axon guidance; axonogenesis; negative regulation of collateral sprouting

Disease: Colorectal Cancer; Esophageal Cancer; Mirror Movements 1
 DCC ELISA Kit
 DCC Recombinant
 DCC Antibody
 IGDCC1 ELISA Kit
 IGDCC1 Recombinant
 IGDCC1 Antibody
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Netrin receptor unc-5

 Netrin receptor unc-5 ELISA Kit
 Netrin receptor unc-5 Recombinant
 Netrin receptor unc-5 Antibody
Also known as Netrin receptor unc-5 (Unc5 netrin receptor).
Receptor for netrin required for motor axon guidance. Mediates both short- and long-range axon motor repulsion in the developing nervous system upon ligand binding. Also involved in glial migration. While short-range repulsion requires both fra and unc-5, long-range repulsion only requires unc-5.
 unc-5 ELISA Kit
 unc-5 Recombinant
 unc-5 Antibody
 CG8166 ELISA Kit
 CG8166 Recombinant
 CG8166 Antibody
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Netrin receptor unc-5 homolog

 Netrin receptor unc-5 homolog ELISA Kit
 Netrin receptor unc-5 homolog Recombinant
 Netrin receptor unc-5 homolog Antibody
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding ().
 UNC-5 ELISA Kit
 UNC-5 Recombinant
 UNC-5 Antibody
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Netrin receptor UNC5A

 Netrin receptor UNC5A ELISA Kit
 Netrin receptor UNC5A Recombinant
 Netrin receptor UNC5A Antibody
Also known as Netrin receptor UNC5A (Protein unc-5 homolog 1) (Protein unc-5 homolog A).
UNC5A: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Belongs to the unc-5 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell
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development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q35.2

Cellular Component: intrinsic to plasma membrane; plasma membrane

Biological Process: axon guidance; neurite development
 UNC5A ELISA Kit
 UNC5A Recombinant
 UNC5A Antibody
 KIAA1976 ELISA Kit
 KIAA1976 Recombinant
 KIAA1976 Antibody
 UNC5H1 ELISA Kit
 UNC5H1 Recombinant
 UNC5H1 Antibody
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Netrin receptor UNC5B

 Netrin receptor UNC5B ELISA Kit
 Netrin receptor UNC5B Recombinant
 Netrin receptor UNC5B Antibody
Also known as Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B).
UNC5B: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence recept
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or required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity. Belongs to the unc-5 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: lipid raft

Molecular Function: netrin receptor activity; protein binding

Biological Process: anterior/posterior axon guidance; axon guidance; negative regulation of neuron apoptosis; positive regulation of phosphoinositide 3-kinase cascade
 Unc5b ELISA Kit
 Unc5b Recombinant
 Unc5b Antibody
 Unc5h2 ELISA Kit
 Unc5h2 Recombinant
 Unc5h2 Antibody
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Netrin receptor UNC5B-a

 Netrin receptor UNC5B-a ELISA Kit
 Netrin receptor UNC5B-a Recombinant
 Netrin receptor UNC5B-a Antibody
Also known as Netrin receptor UNC5B-a (Protein Xunc-5) (Protein unc-5 homolog-a).
Plays a role in cell-cell adhesion during embryonic development. Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding ().
 unc5b-a ELISA Kit
 unc5b-a Recombinant
 unc5b-a Antibody
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Netrin receptor UNC5B-b

 Netrin receptor UNC5B-b ELISA Kit
 Netrin receptor UNC5B-b Recombinant
 Netrin receptor UNC5B-b Antibody
Also known as Netrin receptor UNC5B-b (Protein unc-5 homolog-b) (Unc-5-like protein B).
Plays a role in cell-cell adhesion during embryonic development (PubMed:19492039). Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding ().
 unc5b-b ELISA Kit
 unc5b-b Recombinant
 unc5b-b Antibody
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Netrin receptor UNC5C

 Netrin receptor UNC5C ELISA Kit
 Netrin receptor UNC5C Recombinant
 Netrin receptor UNC5C Antibody
Also known as Netrin receptor UNC5C (Protein unc-5 homolog 3) (cUNC-5H3) (Protein unc-5 homolog C).
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.
 UNC5C ELISA Kit
 UNC5C Recombinant
 UNC5C Antibody
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Netrin receptor UNC5D

 Netrin receptor UNC5D ELISA Kit
 Netrin receptor UNC5D Recombinant
 Netrin receptor UNC5D Antibody
Also known as Netrin receptor UNC5D (Protein unc-5 homolog 4) (Protein unc-5 homolog D).
UNC5D: Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a depende
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nce receptor required for apoptosis induction when not associated with netrin ligand. Belongs to the unc-5 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: cell surface

Molecular Function: protein binding

Biological Process: axon guidance; pyramidal neuron differentiation
 Unc5d ELISA Kit
 Unc5d Recombinant
 Unc5d Antibody
 Unc5h4 ELISA Kit
 Unc5h4 Recombinant
 Unc5h4 Antibody
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