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Neural retina-specific leucine zipper protein

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Transcription factor which regulates the expression of several rod-specific genes, in cluding RHO and PDE6B.

Below are the list of possible Neural retina-specific leucine zipper protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Neural retina-specific leucine zipper protein

 Neural retina-specific leucine zipper protein ELISA Kit
 Neural retina-specific leucine zipper protein Recombinant
 Neural retina-specific leucine zipper protein Antibody
Also known as Neural retina-specific leucine zipper protein (NRL).
NRL: Transcription factor which regulates the expression of several rod-specific genes, in cluding RHO and PDE6B. Defects in NRL are the cause of retinitis pigmentosa type 27 (RP27). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As
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their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP27 inheritance is autosomal dominant. Defects in NRL are a cause of retinal degeneration autosomal recessive clumped pigment type (RDCP). A retinopathy characterized by night blindness since early childhood, consistent with a severe reduction in rod function. Color vision is normal although there is a relatively enhanced function of short-wavelength-sensitive cones in the macula. Signs of retinal degeneration and clusters of clumped pigment deposits in the peripheral fundus at the level of the retinal pigment epithelium are present (clumped pigmentary retinal degeneration). Belongs to the bZIP family.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 14q11.1-q11.2

Molecular Function: DNA binding; leucine zipper domain binding; protein binding

Biological Process: positive regulation of transcription from RNA polymerase II promoter; regulation of rhodopsin gene expression; retinal rod cell development; transcription from RNA polymerase II promoter

Disease: Retinitis Pigmentosa 27
 NRL ELISA Kit
 NRL Recombinant
 NRL Antibody
 D14S46E ELISA Kit
 D14S46E Recombinant
 D14S46E Antibody
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