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Neurexin

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Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels (By similarity). Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom.

Below are the list of possible Neurexin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Neurexin-1

 Neurexin-1 ELISA Kit
 Neurexin-1 Recombinant
 Neurexin-1 Antibody
Also known as Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha).
Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the
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regulation of calcium channel activity and Ca2+-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca2+-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels (). Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom.
 NRXN1 ELISA Kit
 NRXN1 Recombinant
 NRXN1 Antibody
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Neurexin-1a

 Neurexin-1a ELISA Kit
 Neurexin-1a Recombinant
 Neurexin-1a Antibody
Also known as Neurexin-1a (Neurexin Ia-alpha) (Neurexin-1a-alpha).
This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. I
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n vertebrates, alternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. In zebrafish, morpholino knockdown of an alpha isoform results in defects in balance and reduced locomotor activity. Knockdown of a beta isoform results in defects in sprouting angiogenesis and vascular remodeling. Alternative splicing and promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2016]
 nrxn1a ELISA Kit
 nrxn1a Recombinant
 nrxn1a Antibody
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Neurexin-1a-beta

 Neurexin-1a-beta ELISA Kit
 Neurexin-1a-beta Recombinant
 Neurexin-1a-beta Antibody
Also known as Neurexin-1a-beta (Neurexin Ia-beta).
This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. In vertebrates, a
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lternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. In zebrafish, morpholino knockdown of an alpha isoform results in defects in balance and reduced locomotor activity. Knockdown of a beta isoform results in defects in sprouting angiogenesis and vascular remodeling. Alternative splicing and promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2016]
 nrxn1a ELISA Kit
 nrxn1a Recombinant
 nrxn1a Antibody
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Neurexin-1b

 Neurexin-1b ELISA Kit
 Neurexin-1b Recombinant
 Neurexin-1b Antibody
Also known as Neurexin-1b (Neurexin Ib-alpha) (Neurexin-1b-alpha).
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.
 nrxn1b ELISA Kit
 nrxn1b Recombinant
 nrxn1b Antibody
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Neurexin-1b-beta

 Neurexin-1b-beta ELISA Kit
 Neurexin-1b-beta Recombinant
 Neurexin-1b-beta Antibody
Also known as Neurexin-1b-beta (Neurexin Ib-beta).
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in formation or maintenance of synaptic junctions.
 nrxn1b ELISA Kit
 nrxn1b Recombinant
 nrxn1b Antibody
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Neurexin-1-beta

 Neurexin-1-beta ELISA Kit
 Neurexin-1-beta Recombinant
 Neurexin-1-beta Antibody
Also known as Neurexin-1-beta (Neurexin I-beta).
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling (). Plays a role in angiogenesis.
 NRXN1 ELISA Kit
 NRXN1 Recombinant
 NRXN1 Antibody
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Neurexin-2

 Neurexin-2 ELISA Kit
 Neurexin-2 Recombinant
 Neurexin-2 Antibody
Also known as Neurexin-2 (Neurexin II-alpha) (Neurexin-2-alpha).
NRXN2: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. Belongs to the neurexin family. 3 isoforms of the human protein are produced by alternative promoter.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Hu
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man Ortholog: 11q13

Molecular Function: calcium channel regulator activity; cell adhesion molecule binding; transmembrane receptor activity

Biological Process: adult behavior; neuron adhesion; neurotransmitter secretion; signal transduction; social behavior; synaptic transmission; synaptogenesis; vocal learning
 NRXN2 ELISA Kit
 NRXN2 Recombinant
 NRXN2 Antibody
 KIAA0921 ELISA Kit
 KIAA0921 Recombinant
 KIAA0921 Antibody
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Neurexin-2-beta

 Neurexin-2-beta ELISA Kit
 Neurexin-2-beta Recombinant
 Neurexin-2-beta Antibody
Also known as Neurexin-2-beta (Neurexin II-beta).
NRXN2 iso3: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. Belongs to the neurexin family. 3 isoforms of the human protein are produced by alternative promoter.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Orthol
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og: 11q13

Molecular Function: calcium channel regulator activity; cell adhesion molecule binding; transmembrane receptor activity

Biological Process: adult behavior; neuron adhesion; neurotransmitter secretion; signal transduction; social behavior; synaptic transmission; synaptogenesis; vocal learning
 NRXN2 ELISA Kit
 NRXN2 Recombinant
 NRXN2 Antibody
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Neurexin-3

 Neurexin-3 ELISA Kit
 Neurexin-3 Recombinant
 Neurexin-3 Antibody
Also known as Neurexin-3 (Neurexin III-alpha) (Neurexin-3-alpha).
NRXN3: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. Belongs to the neurexin family. 7 isoforms of the human protein are produced by alternative promoter.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 14q31

Cellular Component: integral to plasma membrane

Molecular Function: cell adhesion molecule binding; receptor activity

Biological Process: adult behavior; ax
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on guidance; learning; neuron adhesion; social behavior
 NRXN3 ELISA Kit
 NRXN3 Recombinant
 NRXN3 Antibody
 C14orf60 ELISA Kit
 C14orf60 Recombinant
 C14orf60 Antibody
 KIAA0743 ELISA Kit
 KIAA0743 Recombinant
 KIAA0743 Antibody
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Neurexin-3a

 Neurexin-3a ELISA Kit
 Neurexin-3a Recombinant
 Neurexin-3a Antibody
Also known as Neurexin-3a (Neurexin IIIa-alpha) (Neurexin-3a-alpha).
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.
 nrxn3a ELISA Kit
 nrxn3a Recombinant
 nrxn3a Antibody
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Neurexin-3a-beta

 Neurexin-3a-beta ELISA Kit
 Neurexin-3a-beta Recombinant
 Neurexin-3a-beta Antibody
Also known as Neurexin-3a-beta (Neurexin IIIb-beta).
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.
 nrxn3a ELISA Kit
 nrxn3a Recombinant
 nrxn3a Antibody
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Neurexin-3b

 Neurexin-3b ELISA Kit
 Neurexin-3b Recombinant
 Neurexin-3b Antibody
Also known as Neurexin-3b (Neurexin IIIb-alpha) (Neurexin-3b-alpha).
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.
 nrxn3b ELISA Kit
 nrxn3b Recombinant
 nrxn3b Antibody
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Neurexin-3b-beta

 Neurexin-3b-beta ELISA Kit
 Neurexin-3b-beta Recombinant
 Neurexin-3b-beta Antibody
Also known as Neurexin-3b-beta (Neurexin IIIb-beta).
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.
 nrxn3b ELISA Kit
 nrxn3b Recombinant
 nrxn3b Antibody
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Neurexin-3-beta

 Neurexin-3-beta ELISA Kit
 Neurexin-3-beta Recombinant
 Neurexin-3-beta Antibody
Also known as Neurexin-3-beta (Neurexin III-beta).
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion (). Plays a role in angiogenesis.
 NRXN3 ELISA Kit
 NRXN3 Recombinant
 NRXN3 Antibody
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Neurexin-4

 Neurexin-4 ELISA Kit
 Neurexin-4 Recombinant
 Neurexin-4 Antibody
Also known as Neurexin-4 (Neurexin IV).
Seems to play a role in the formation and function of septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation.
 Nrx-IV ELISA Kit
 Nrx-IV Recombinant
 Nrx-IV Antibody
 Nrx ELISA Kit
 Nrx Recombinant
 Nrx Antibody
 CG6827 ELISA Kit
 CG6827 Recombinant
 CG6827 Antibody
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