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Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.

Below are the list of possible Neurofibromin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.


 Neurofibromin ELISA Kit
 Neurofibromin Recombinant
 Neurofibromin Antibody
Also known as Neurofibromin (Neurofibromatosis-related protein NF-1).
NF1: a Ras-GAP, highly expressed in developing neural cells. Possesses tumor suppressor activity, presumably by virtue of its GTPase activating domain. Neurofibromin is phosphorylated in response to EGF in CNS cells and cell lines. Defects in NF1 are the cause of type 1 neurofibromatosis (NF1), Watson syndrome, and familial s
pinal neurofibromatosis. NF1 is one of the most frequent autosomal dominant diseases. Four alternatively spliced isoforms have been described.

Protein type: GAPs; GAPs, Ras; Motility/polarity/chemotaxis; Nucleolus; Tumor suppressor

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: axon; cytoplasm; cytosol; dendrite; membrane; nucleus

Molecular Function: GTPase activator activity; phosphatidylcholine binding; phosphatidylethanolamine binding; protein binding

Biological Process: actin cytoskeleton organization and biogenesis; adrenal gland development; artery morphogenesis; brain development; camera-type eye morphogenesis; cell communication; cerebral cortex development; cognition; collagen fibril organization; extracellular matrix organization and biogenesis; forebrain astrocyte development; forebrain morphogenesis; heart development; liver development; MAPKKK cascade; metanephros development; myelination in the peripheral nervous system; negative regulation of cell migration; negative regulation of endothelial cell proliferation; negative regulation of fibroblast proliferation; negative regulation of MAP kinase activity; negative regulation of MAPKKK cascade; negative regulation of neuroblast proliferation; negative regulation of oligodendrocyte differentiation; negative regulation of protein kinase activity; negative regulation of Ras protein signal transduction; negative regulation of transcription factor import into nucleus; osteoblast differentiation; peripheral nervous system development; phosphoinositide 3-kinase cascade; pigmentation; positive regulation of adenylate cyclase activity; positive regulation of apoptosis; positive regulation of GTPase activity; positive regulation of neuron apoptosis; Ras protein signal transduction; regulation of angiogenesis; regulation of blood vessel endothelial cell migration; regulation of bone resorption; regulation of cell-matrix adhesion; regulation of glial cell differentiation; regulation of GTPase activity; response to hypoxia; Schwann cell development; smooth muscle development; spinal cord development; sympathetic nervous system development; visual learning; wound healing

Disease: Juvenile Myelomonocytic Leukemia; Neurofibromatosis, Familial Spinal; Neurofibromatosis, Type I; Neurofibromatosis-noonan Syndrome; Watson Syndrome
 NF1 Recombinant
 NF1 Antibody
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 Neurofibromin-A ELISA Kit
 Neurofibromin-A Recombinant
 Neurofibromin-A Antibody
Also known as Neurofibromin-A (DdNF1).
Regulator of the GTPase activity of Ras, mainly RasG and RasB.
 nfaA ELISA Kit
 nfaA Recombinant
 nfaA Antibody
 DDB_G0271750 ELISA Kit
 DDB_G0271750 Recombinant
 DDB_G0271750 Antibody
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