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Neurogenic locus notch homolog protein

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Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A (By similarity). Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (By similarity).

Below are the list of possible Neurogenic locus notch homolog protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Neurogenic locus notch homolog protein 1

 Neurogenic locus notch homolog protein 1 ELISA Kit
 Neurogenic locus notch homolog protein 1 Recombinant
 Neurogenic locus notch homolog protein 1 Antibody
Also known as Neurogenic locus notch homolog protein 1 (Notch 1).
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementat
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ion of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A (). Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) ().
 NOTCH1 ELISA Kit
 NOTCH1 Recombinant
 NOTCH1 Antibody
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Neurogenic locus notch homolog protein 2

 Neurogenic locus notch homolog protein 2 ELISA Kit
 Neurogenic locus notch homolog protein 2 Recombinant
 Neurogenic locus notch homolog protein 2 Antibody
Also known as Neurogenic locus notch homolog protein 2 (Notch 2).
Notch 2: a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. Affects the implementation o
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f differentiation, proliferation and apoptotic programs. Cleaved in the trans-Golgi network and presented on the cell surface as a heterodimer. This protein functions as a receptor for the membrane bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Cellular Component: cell surface; cilium; cytosol; extracellular region; integral to plasma membrane; membrane; nucleoplasm; nucleus; plasma membrane; receptor complex

Molecular Function: enzyme binding; NF-kappaB binding; receptor activity

Biological Process: bone remodeling; cell cycle arrest; cell fate determination; cell growth; defense response to bacterium; determination of left/right symmetry; embryonic limb morphogenesis; heart looping; humoral immune response; in utero embryonic development; inflammatory response to antigenic stimulus; liver development; marginal zone B cell differentiation; morphogenesis of an epithelial sheet; multicellular organism growth; myeloid dendritic cell differentiation; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; organ morphogenesis; placenta development; positive regulation of apoptosis; positive regulation of BMP signaling pathway; positive regulation of cell proliferation; positive regulation of osteoclast differentiation; positive regulation of Ras protein signal transduction; regulation of transcription from RNA polymerase II promoter; tissue regeneration; wound healing
 Notch2 ELISA Kit
 Notch2 Recombinant
 Notch2 Antibody
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Neurogenic locus notch homolog protein 3

 Neurogenic locus notch homolog protein 3 ELISA Kit
 Neurogenic locus notch homolog protein 3 Recombinant
 Neurogenic locus notch homolog protein 3 Antibody
Also known as Neurogenic locus notch homolog protein 3 (Notch 3).
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementat
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ion of differentiation, proliferation and apoptotic programs (). Acts instructively to control the cell fate determination of CNS multipotent progenitor cells, resulting in astroglial induction and neuron/oligodendrocyte suppression.
 Notch3 ELISA Kit
 Notch3 Recombinant
 Notch3 Antibody
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Neurogenic locus notch homolog protein 4

 Neurogenic locus notch homolog protein 4 ELISA Kit
 Neurogenic locus notch homolog protein 4 Recombinant
 Neurogenic locus notch homolog protein 4 Antibody
Also known as Neurogenic locus notch homolog protein 4 (Notch 4).
NOTCH4: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system. Heterodimer of a C-terminal fragment N(TM) and a N- termin
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al fragment N(EC) which are probably linked by disulfide bonds. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH4. Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes. Belongs to the NOTCH family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: cell surface; cytoplasmic vesicle; endoplasmic reticulum

Molecular Function: Notch binding; protein binding

Biological Process: embryonic development; endothelial cell differentiation; endothelial cell morphogenesis; mammary gland development; morphogenesis of a branching structure; negative regulation of endothelial cell differentiation; negative regulation of Notch signaling pathway; Notch signaling pathway; patterning of blood vessels; positive regulation of angiogenesis; regulation of Notch signaling pathway; regulation of protein localization; venous blood vessel morphogenesis
 Notch4 ELISA Kit
 Notch4 Recombinant
 Notch4 Antibody
 Int-3 ELISA Kit
 Int-3 Recombinant
 Int-3 Antibody
 Int3 ELISA Kit
 Int3 Recombinant
 Int3 Antibody
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