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Neutral ceramidase

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Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract.

Below are the list of possible Neutral ceramidase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Neutral ceramidase

 Neutral ceramidase ELISA Kit
 Neutral ceramidase Recombinant
 Neutral ceramidase Antibody
Also known as Neutral ceramidase (N-CDase) (NCDase) (Acylsphingosine deacylase 2) (BCDase) (LCDase) (hCD) (N-acylsphingosine amidohydrolase 2) (Non-lysosomal ceramidase).
ASAH2: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as
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a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract. Belongs to the neutral ceramidase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.5.1.23; Hydrolase; Lipid Metabolism - sphingolipid; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10q11.21

Cellular Component: mitochondrion

Biological Process: ceramide metabolic process; signal transduction
 ASAH2 ELISA Kit
 ASAH2 Recombinant
 ASAH2 Antibody
 HNAC1 ELISA Kit
 HNAC1 Recombinant
 HNAC1 Antibody
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Neutral ceramidase A

 Neutral ceramidase A ELISA Kit
 Neutral ceramidase A Recombinant
 Neutral ceramidase A Antibody
Also known as Neutral ceramidase A (N-CDase A) (NCDase A) (Acylsphingosine deacylase 2A) (N-acylsphingosine amidohydrolase 2A).
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 3.0. Has no activity toward glycosphingolipids, such as GalCer and Galbeta1-3GalNAcbeta1-4(NeuAcalpha2-3)Galbeta1-4Glcbeta1-1'Cer or sphingomyelin.
 dcd2A ELISA Kit
 dcd2A Recombinant
 dcd2A Antibody
 dcd ELISA Kit
 dcd Recombinant
 dcd Antibody
 rsc25 ELISA Kit
 rsc25 Recombinant
 rsc25 Antibody
 DDB_G0293538 ELISA Kit
 DDB_G0293538 Recombinant
 DDB_G0293538 Antibody
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Neutral ceramidase B

 Neutral ceramidase B ELISA Kit
 Neutral ceramidase B Recombinant
 Neutral ceramidase B Antibody
Also known as Neutral ceramidase B (N-CDase B) (NCDase B) (Acylsphingosine deacylase 2B) (N-acylsphingosine amidohydrolase 2B).
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
 dcd2B ELISA Kit
 dcd2B Recombinant
 dcd2B Antibody
 DDB_G0268374 ELISA Kit
 DDB_G0268374 Recombinant
 DDB_G0268374 Antibody
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