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Neutrophil cytosol factor

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NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).

Below are the list of possible Neutrophil cytosol factor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Neutrophil cytosol factor 1

 Neutrophil cytosol factor 1 ELISA Kit
 Neutrophil cytosol factor 1 Recombinant
 Neutrophil cytosol factor 1 Antibody
Also known as Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox).
p47phox: the 47-kilodalton cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils. The holo-oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Contains 2 SH2 domains. Mutations in NCF1, as well as in other NADPH oxidase subun
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its, can result in chronic granulomatous disease.

Protein type: EC 1.-.-.-; Oxidoreductase

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: cytosol; extrinsic to membrane; NADPH oxidase complex

Molecular Function: electron carrier activity; phosphatidylinositol-3,4-bisphosphate binding; phosphoinositide binding; protein binding; SH3 domain binding; superoxide-generating NADPH oxidase activator activity; superoxide-generating NADPH oxidase activity

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell redox homeostasis; cellular defense response; innate immune response; protein targeting to membrane; respiratory burst; superoxide metabolic process; superoxide release; vascular endothelial growth factor receptor signaling pathway

Disease: Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-positive, Type I
 NCF1 ELISA Kit
 NCF1 Recombinant
 NCF1 Antibody
 NOXO2 ELISA Kit
 NOXO2 Recombinant
 NOXO2 Antibody
 SH3PXD1A ELISA Kit
 SH3PXD1A Recombinant
 SH3PXD1A Antibody
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Neutrophil cytosol factor 2

 Neutrophil cytosol factor 2 ELISA Kit
 Neutrophil cytosol factor 2 Recombinant
 Neutrophil cytosol factor 2 Antibody
Also known as Neutrophil cytosol factor 2 (NCF-2) (67 kDa neutrophil oxidase factor) (NADPH oxidase activator 2) (Neutrophil NADPH oxidase factor 2) (p67-phox).
p67phox: NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Interacts with SYTL1 and RAC1. Interacts with NCF4. May interact with NOXO1. Belongs to the NCF2/NOXA1 family.

Protein type: Oxidoreductase

Cellular Component: acrosome; cytoplasm; cytosol; membrane; nucleolus

Molecular Function: protein binding; protein C-termi
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nus binding; Rac GTPase binding; superoxide-generating NADPH oxidase activity

Biological Process: cellular response to hormone stimulus; NADP catabolic process; positive regulation of blood pressure; positive regulation of neuron apoptosis; response to glucose stimulus; response to lipopolysaccharide; response to organic cyclic substance; superoxide metabolic process; superoxide release
 Ncf2 ELISA Kit
 Ncf2 Recombinant
 Ncf2 Antibody
 Noxa2 ELISA Kit
 Noxa2 Recombinant
 Noxa2 Antibody
 P67phox ELISA Kit
 P67phox Recombinant
 P67phox Antibody
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Neutrophil cytosol factor 4

 Neutrophil cytosol factor 4 ELISA Kit
 Neutrophil cytosol factor 4 Recombinant
 Neutrophil cytosol factor 4 Antibody
Also known as Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).
p40phox: a component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst. Upon neutrophil stimulation, this protein and other cytosolic elements are sent to the cell membrane from the cytosol to form a complex which produces phagocytic oxygen radicals.
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Responsible for the downregulation of NADPH-oxidase. Alternative splicing has been observed.

Protein type: Oxidoreductase

Cellular Component: cytoplasm; cytosol; endosome membrane; membrane; NADPH oxidase complex

Molecular Function: phosphatidylinositol 3-phosphate binding; protein binding; superoxide-generating NADPH oxidase activator activity
 Ncf4 ELISA Kit
 Ncf4 Recombinant
 Ncf4 Antibody
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