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NF-kappa-B inhibitor

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Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

Below are the list of possible NF-kappa-B inhibitor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

NF-kappa-B inhibitor alpha

 NF-kappa-B inhibitor alpha ELISA Kit
 NF-kappa-B inhibitor alpha Recombinant
 NF-kappa-B inhibitor alpha Antibody
Also known as NF-kappa-B inhibitor alpha (ECI-6) (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha).
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeri
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c RELA to translocate to the nucleus and activate transcription.
 NFKBIA ELISA Kit
 NFKBIA Recombinant
 NFKBIA Antibody
 IKBA ELISA Kit
 IKBA Recombinant
 IKBA Antibody
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NF-kappa-B inhibitor beta

 NF-kappa-B inhibitor beta ELISA Kit
 NF-kappa-B inhibitor beta Recombinant
 NF-kappa-B inhibitor beta Antibody
Also known as NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta).
This gene encodes an inhibitor of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB). The encoded protein prevents NF-kappaB-mediated transcription activation by sequestering it in the cytosol. In response to signals that induce NF-kappaB, such as cytokines and growt
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h factors, the encoded protein undergoes phosphorylation, triggering its rapid ubiquitination and proteasomal degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
 Nfkbib ELISA Kit
 Nfkbib Recombinant
 Nfkbib Antibody
 Ikbb ELISA Kit
 Ikbb Recombinant
 Ikbb Antibody
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NF-kappa-B inhibitor cactus

 NF-kappa-B inhibitor cactus ELISA Kit
 NF-kappa-B inhibitor cactus Recombinant
 NF-kappa-B inhibitor cactus Antibody
Involved in the formation of the dorsoventral pattern. It inhibits nuclear translocation of the dorsal morphogen in the dorsal region of the embryo.
 cact ELISA Kit
 cact Recombinant
 cact Antibody
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NF-kappa-B inhibitor delta

 NF-kappa-B inhibitor delta ELISA Kit
 NF-kappa-B inhibitor delta Recombinant
 NF-kappa-B inhibitor delta Antibody
Also known as NF-kappa-B inhibitor delta (I-kappa-B-delta) (IkB-delta) (IkappaBdelta) (IkappaBNS).
NFKBID: May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR- induced negative selection of thymocytes. Belongs to the NF-kappa-B inhibitor family. 3 isoforms of the hu
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man protein are produced by alternative splicing.

Cellular Component: nucleus

Molecular Function: NF-kappaB binding; protein binding; transcription cofactor activity

Biological Process: inhibition of NF-kappaB transcription factor; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of T cell differentiation in the thymus; regulation of transcription from RNA polymerase II promoter
 Nfkbid ELISA Kit
 Nfkbid Recombinant
 Nfkbid Antibody
 Ikbns ELISA Kit
 Ikbns Recombinant
 Ikbns Antibody
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NF-kappa-B inhibitor epsilon

 NF-kappa-B inhibitor epsilon ELISA Kit
 NF-kappa-B inhibitor epsilon Recombinant
 NF-kappa-B inhibitor epsilon Antibody
Also known as NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon).
IkB-epsilon: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit. Highly
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expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages. Belongs to the NF-kappa-B inhibitor family.

Protein type: DNA-binding; Inhibitor

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: cytoplasm; cytosol

Molecular Function: protein binding

Biological Process: cytoplasmic sequestering of transcription factor
 NFKBIE ELISA Kit
 NFKBIE Recombinant
 NFKBIE Antibody
 IKBE ELISA Kit
 IKBE Recombinant
 IKBE Antibody
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NF-kappa-B inhibitor zeta

 NF-kappa-B inhibitor zeta ELISA Kit
 NF-kappa-B inhibitor zeta Recombinant
 NF-kappa-B inhibitor zeta Antibody
Also known as NF-kappa-B inhibitor zeta (I-kappa-B-zeta) (IkB-zeta) (IkappaBzeta) (IL-1 inducible nuclear ankyrin-repeat protein) (INAP) (Molecule possessing ankyrin repeats induced by lipopolysaccharide) (MAIL).
IkB-zeta: Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF- kappa-B-mediated transcription. In vitro, upon association with
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NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis. Interacts with NFKB1/p50. Interacts with RELA. By TNF, IL1/interleukin-1 and bacterial lipopolysaccharides (LPS). Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 3p12-q12

Cellular Component: nucleus

Molecular Function: protein binding; transcription cofactor activity

Biological Process: regulation of transcription from RNA polymerase II promoter
 NFKBIZ ELISA Kit
 NFKBIZ Recombinant
 NFKBIZ Antibody
 IKBZ ELISA Kit
 IKBZ Recombinant
 IKBZ Antibody
 INAP ELISA Kit
 INAP Recombinant
 INAP Antibody
 MAIL ELISA Kit
 MAIL Recombinant
 MAIL Antibody
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Proteins Root Name Listing
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