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Nibrin

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Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (By similarity).

Below are the list of possible Nibrin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Nibrin

 Nibrin ELISA Kit
 Nibrin Recombinant
 Nibrin Antibody
Also known as Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1 homolog).
NBS1: a member of the MRE11/RAD50 double-strand break repair complex. Involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. Mutation results in the Nijmegen breakage syndrome (NBS), an autosomal recessive chromosomal instability syndrome.

Protein ty
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pe: Cell cycle regulation; DNA repair, damage

Cellular Component: Mre11 complex; nuclear chromosome, telomeric region; nuclear inclusion body; nucleolus; nucleus; PML body; replication fork

Molecular Function: ATP-dependent DNA helicase activity; damaged DNA binding; protein N-terminus binding; transcription factor binding

Biological Process: blastocyst growth; cell proliferation; DNA damage checkpoint; DNA damage response, signal transduction; DNA duplex unwinding; double-strand break repair; double-strand break repair via homologous recombination; in utero embryonic development; isotype switching; mitotic cell cycle checkpoint; mitotic cell cycle G2/M transition DNA damage checkpoint; negative regulation of neuron differentiation; negative regulation of virion penetration into host cell; neuromuscular process controlling balance; positive regulation of cell proliferation; positive regulation of kinase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of telomere maintenance; regulation of fibroblast proliferation; telomere capping; telomere maintenance; telomeric 3' overhang formation
 Nbn ELISA Kit
 Nbn Recombinant
 Nbn Antibody
 Nbs1 ELISA Kit
 Nbs1 Recombinant
 Nbs1 Antibody
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