| Nicastrin ELISA Kit|
|nicastrin: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. Component of the gamma-secretase complex, a complex composed of a presen |
ilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist. Binds to proteolytic processed C-terminal fragments C83 and C99 of the amyloid precursor protein (APP). Constitutively expressed in neural cells. Widely expressed. Belongs to the nicastrin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Cellular Component: endoplasmic reticulum; focal adhesion; Golgi apparatus; integral to plasma membrane; lysosomal membrane; membrane; plasma membrane
Molecular Function: endopeptidase activity; peptidase activity; protein binding
Biological Process: beta-amyloid metabolic process; epithelial cell proliferation; membrane protein ectodomain proteolysis; myeloid cell homeostasis; positive regulation of catalytic activity; protein processing; T cell proliferation
| Ncstn ELISA Kit|