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Nicotinamide phosphoribosyltransferase

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The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma (By similarity). Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression.

Below are the list of possible Nicotinamide phosphoribosyltransferase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Nicotinamide phosphoribosyltransferase

 Nicotinamide phosphoribosyltransferase ELISA Kit
 Nicotinamide phosphoribosyltransferase Recombinant
 Nicotinamide phosphoribosyltransferase Antibody
Also known as Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (Pre-B-cell colony-enhancing factor 1 homolog) (PBEF) (Visfatin).
PBEF: an ubiquitous protein originally described as a cytokine which acts on early B-lineage precursor cells. Other reports indicate that PBEF is not a cytokine-like secreted protein but an intracellular protein associated with the cell cycle. Contains a cat
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alytically active nicotinate phosphoribosyltransferase domain, an enzyme involved in nicotinamide adenine dinucleotide (NAD) biosynthesis.

Protein type: Cell cycle regulation; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cytokine; EC 2.4.2.12; Transferase

Cellular Component: cell junction; cytoplasm; nucleoplasm; nucleus

Molecular Function: cytokine activity; drug binding; nicotinamide phosphoribosyltransferase activity; protein homodimerization activity

Biological Process: circadian regulation of gene expression; circadian rhythm; NAD biosynthetic process; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter
 Nampt ELISA Kit
 Nampt Recombinant
 Nampt Antibody
 Pbef1 ELISA Kit
 Pbef1 Recombinant
 Pbef1 Antibody
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