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Niemann-Pick C1 protein

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Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (By similarity).

Below are the list of possible Niemann-Pick C1 protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Niemann-Pick C1 protein

 Niemann-Pick C1 protein ELISA Kit
 Niemann-Pick C1 protein Recombinant
 Niemann-Pick C1 protein Antibody
Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. N
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PC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals ().
 NPC1 ELISA Kit
 NPC1 Recombinant
 NPC1 Antibody
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Niemann-Pick C1 protein homolog 1

 Niemann-Pick C1 protein homolog 1 ELISA Kit
 Niemann-Pick C1 protein homolog 1 Recombinant
 Niemann-Pick C1 protein homolog 1 Antibody
Involved in the uptake or utilization of cholesterol. Ncr-1 and ncr-2 act redundantly to prevent dauer larva formation under favorable growth conditions, and are required for the normal functioning of ADF, ASI and ASG neurons.
 ncr-1 ELISA Kit
 ncr-1 Recombinant
 ncr-1 Antibody
 npc-1 ELISA Kit
 npc-1 Recombinant
 npc-1 Antibody
 F02E8.6 ELISA Kit
 F02E8.6 Recombinant
 F02E8.6 Antibody
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Niemann-Pick C1 protein homolog 2

 Niemann-Pick C1 protein homolog 2 ELISA Kit
 Niemann-Pick C1 protein homolog 2 Recombinant
 Niemann-Pick C1 protein homolog 2 Antibody
Involved in the uptake or utilization of cholesterol. Ncr-1 and ncr-2 act redundantly to prevent dauer larva formation under favorable growth conditions, and are required for the normal functioning of ADF, ASI and ASG neurons.
 ncr-2 ELISA Kit
 ncr-2 Recombinant
 ncr-2 Antibody
 npc-2 ELISA Kit
 npc-2 Recombinant
 npc-2 Antibody
 F09G8.4 ELISA Kit
 F09G8.4 Recombinant
 F09G8.4 Antibody
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