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NKG2D ligand

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Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Below are the list of possible NKG2D ligand products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

NKG2D ligand 1

 NKG2D ligand 1 ELISA Kit
 NKG2D ligand 1 Recombinant
 NKG2D ligand 1 Antibody
Also known as NKG2D ligand 1 (N2DL-1) (NKG2DL1) (ALCAN-beta) (Retinoic acid early transcript 1I) (UL16-binding protein 1).
ULBP1: Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with
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the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis- Golgi apparatus so that it does not reach the cell surface. Belongs to the MHC class I family.

Protein type: Apoptosis; Cell surface; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 6q25

Cellular Component: anchored to plasma membrane; plasma membrane

Molecular Function: antigen binding; natural killer cell lectin-like receptor binding

Biological Process: antigen processing and presentation; natural killer cell activation; natural killer cell mediated cytotoxicity; regulation of immune response
 ULBP1 ELISA Kit
 ULBP1 Recombinant
 ULBP1 Antibody
 N2DL1 ELISA Kit
 N2DL1 Recombinant
 N2DL1 Antibody
 RAET1I ELISA Kit
 RAET1I Recombinant
 RAET1I Antibody
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NKG2D ligand 2

 NKG2D ligand 2 ELISA Kit
 NKG2D ligand 2 Recombinant
 NKG2D ligand 2 Antibody
Also known as NKG2D ligand 2 (N2DL-2) (NKG2DL2) (ALCAN-alpha) (Retinoic acid early transcript 1H) (UL16-binding protein 2).
ULBP2: Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with
>>>
the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis- Golgi apparatus so that it does not reach the cell surface. Belongs to the MHC class I family.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 6q25

Cellular Component: anchored to plasma membrane; cell surface; extracellular space

Molecular Function: antigen binding; natural killer cell lectin-like receptor binding

Biological Process: antigen processing and presentation; natural killer cell activation; natural killer cell mediated cytotoxicity
 ULBP2 ELISA Kit
 ULBP2 Recombinant
 ULBP2 Antibody
 N2DL2 ELISA Kit
 N2DL2 Recombinant
 N2DL2 Antibody
 RAET1H ELISA Kit
 RAET1H Recombinant
 RAET1H Antibody
 UNQ463/PRO791 ELISA Kit
 UNQ463/PRO791 Recombinant
 UNQ463/PRO791 Antibody
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NKG2D ligand 3

 NKG2D ligand 3 ELISA Kit
 NKG2D ligand 3 Recombinant
 NKG2D ligand 3 Antibody
Also known as NKG2D ligand 3 (N2DL-3) (NKG2DL3) (ALCAN-gamma) (Retinoic acid early transcript 1N).
ULBP3: Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1. Belongs to the MHC class I
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family.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 6q25

Cellular Component: anchored to plasma membrane; plasma membrane

Molecular Function: antigen binding; natural killer cell lectin-like receptor binding

Biological Process: antigen processing and presentation; natural killer cell activation; natural killer cell mediated cytotoxicity; regulation of immune response
 ULBP3 ELISA Kit
 ULBP3 Recombinant
 ULBP3 Antibody
 N2DL3 ELISA Kit
 N2DL3 Recombinant
 N2DL3 Antibody
 RAET1N ELISA Kit
 RAET1N Recombinant
 RAET1N Antibody
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NKG2D ligand 4

 NKG2D ligand 4 ELISA Kit
 NKG2D ligand 4 Recombinant
 NKG2D ligand 4 Antibody
Also known as NKG2D ligand 4 (N2DL-4) (NKG2DL4) (Lymphocyte effector toxicity activation ligand) (RAE-1-like transcript 4) (RL-4) (Retinoic acid early transcript 1E).
RAET1E: Ligand for the NKG2D receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes. Belongs to the MHC class I family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q25.1

Cellular Component: plasma membrane
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Molecular Function: antigen binding; natural killer cell lectin-like receptor binding

Biological Process: antigen processing and presentation; natural killer cell mediated cytotoxicity; regulation of immune response; T cell mediated cytotoxicity
 RAET1E ELISA Kit
 RAET1E Recombinant
 RAET1E Antibody
 LETAL ELISA Kit
 LETAL Recombinant
 LETAL Antibody
 N2DL4 ELISA Kit
 N2DL4 Recombinant
 N2DL4 Antibody
 ULBP4 ELISA Kit
 ULBP4 Recombinant
 ULBP4 Antibody
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