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Nodal

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Essential for mesoderm formation and axial patterning during embryonic development.

Below are the list of possible Nodal products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Nodal

 Nodal ELISA Kit
 Nodal Recombinant
 Nodal Antibody
NODAL: Essential for mesoderm formation and axial patterning during embryonic development. Defects in NODAL are the cause of visceral heterotaxy autosomal type 5 (HTX5). A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. It results in an abnormal arrangement of visceral organs, and a wide variety of congenital defe
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cts. Clinical features of visceral heterotaxy autosomal type 5 include situs inversus viscerum or situs ambiguus, congenital heart defect, transposition of the great vessels ventricular septal defect, atrial septal defect, truncuscommunis, and dextrocardia. Belongs to the TGF-beta family.

Protein type: Cell development/differentiation; Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; protein binding; receptor agonist activity; transforming growth factor beta receptor binding

Biological Process: anatomical structure formation; anterior/posterior axis specification; anterior/posterior pattern formation; axial mesodermal cell fate specification; BMP signaling pathway; brain development; cell fate commitment; cell migration; cell migration involved in gastrulation; determination of left/right symmetry; digestive tract morphogenesis; embryonic cranial skeleton morphogenesis; embryonic heart tube development; embryonic pattern specification; embryonic placenta development; embryonic process involved in female pregnancy; endoderm development; floor plate morphogenesis; formation of anatomical boundary; gastrulation; gastrulation with mouth forming second; heart development; heart looping; in utero embryonic development; liver development; lung development; maternal placenta development; maternal process involved in parturition; mesendoderm development; mesoderm formation; negative regulation of cell differentiation; negative regulation of transcription from RNA polymerase II promoter; nervous system development; neural fold formation; placenta development; polarity specification of proximal/distal axis; positive regulation of activin receptor signaling pathway; positive regulation of angiogenesis; positive regulation of caspase activity; positive regulation of cell proliferation; positive regulation of cell-cell adhesion; positive regulation of epithelial cell proliferation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; regulation of gastrulation; regulation of MAPKKK cascade; regulation of signal transduction; repression of premature neural plate formation; stem cell maintenance; tissue morphogenesis; transforming growth factor beta receptor signaling pathway; trophectodermal cell differentiation; trophectodermal cellular morphogenesis; vasculature development
 Nodal ELISA Kit
 Nodal Recombinant
 Nodal Antibody
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Nodal homolog

 Nodal homolog ELISA Kit
 Nodal homolog Recombinant
 Nodal homolog Antibody
NODAL: Essential for mesoderm formation and axial patterning during embryonic development. Defects in NODAL are the cause of visceral heterotaxy autosomal type 5 (HTX5). A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. It results in an abnormal arrangement of visceral organs, and a wide variety of congenital defe
>>>
cts. Clinical features of visceral heterotaxy autosomal type 5 include situs inversus viscerum or situs ambiguus, congenital heart defect, transposition of the great vessels ventricular septal defect, atrial septal defect, truncuscommunis, and dextrocardia. Belongs to the TGF-beta family.

Protein type: Cell development/differentiation; Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: extracellular space

Molecular Function: cytokine activity; transforming growth factor beta receptor binding

Biological Process: BMP signaling pathway; mesendoderm development; placenta development; positive regulation of activin receptor signaling pathway; positive regulation of angiogenesis; positive regulation of caspase activity; positive regulation of cell-cell adhesion; positive regulation of epithelial cell proliferation; positive regulation of transcription factor activity

Disease: Heterotaxy, Visceral, 5, Autosomal
 NODAL ELISA Kit
 NODAL Recombinant
 NODAL Antibody
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Nodal homolog 2-A

 Nodal homolog 2-A ELISA Kit
 Nodal homolog 2-A Recombinant
 Nodal homolog 2-A Antibody
Also known as Nodal homolog 2-A (Nodal-related protein 2-A) (Xnr-2-A) (Xnr2-A) (nr-2).
Cooperation and regulatory loops of multiple nodals are essential for mesendoderm patterning in early embryos. Essential for mesoderm formation and axial patterning during embryonic development. Activates the activin-like signaling pathway to induce dorsal and ventral mesoderm in animal cap ectoderm. In addit
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ion, also dorsalizes ventral marginal zone (VMZ) tissues during gastrulation. Induces muscle actin. Appears to act as both a short-range and long-range morphogen. The unprocessed protein inhibits bmp- and wnt-signaling.
 nodal2-a ELISA Kit
 nodal2-a Recombinant
 nodal2-a Antibody
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Nodal homolog 2-B

 Nodal homolog 2-B ELISA Kit
 Nodal homolog 2-B Recombinant
 Nodal homolog 2-B Antibody
Also known as Nodal homolog 2-B (Nodal-related protein 2-B) (Xnr2-B).
Cooperation and regulatory loops of multiple nodals are essential for mesendoderm patterning in early embryos. Essential for mesoderm formation and axial patterning during embryonic development. Activates the activin-like signaling pathway to induce dorsal and ventral mesoderm in animal cap ectoderm. In addition, also dorsali
>>>
zes ventral marginal zone (VMZ) tissues during gastrulation. Induces muscle actin. Appears to act as both a short-range and long-range morphogen. The unprocessed protein inhibits bmp- and wnt-signaling ().
 nodal2-b ELISA Kit
 nodal2-b Recombinant
 nodal2-b Antibody
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Nodal homolog 3-A

 Nodal homolog 3-A ELISA Kit
 Nodal homolog 3-A Recombinant
 Nodal homolog 3-A Antibody
Also known as Nodal homolog 3-A (Nodal-related protein 3-A) (Xnr3) (Xnr3-A).
Exhibits mesoderm-dorsalizing activity and neural-inducing activity, but lacks mesoderm-inducing activity. Regulates the expression of specific mesodermal and neural genes. Induces convergent extension movements at the embryonic midline by activating the fgf signaling pathway to induce t/bra expression in the organizer
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region. Acts with wnt11 to induce Spemann organizer cells and induce axis formation. The unprocessed protein antagonizes bmp-signaling.
 nodal3-a ELISA Kit
 nodal3-a Recombinant
 nodal3-a Antibody
 nr3 ELISA Kit
 nr3 Recombinant
 nr3 Antibody
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Nodal homolog 3-B

 Nodal homolog 3-B ELISA Kit
 Nodal homolog 3-B Recombinant
 Nodal homolog 3-B Antibody
Also known as Nodal homolog 3-B (Fugacin) (Nodal-related protein 3-B) (Xnr3-B).
Exhibits mesoderm-dorsalizing activity and neural-inducing activity, but lacks mesoderm-inducing activity. Regulates the expression of specific mesodermal and neural genes. Induces convergent extension movements at the embryonic midline by activating the fgf signaling pathway to induce t/bra expression in the organi
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zer region. Acts with wnt11 to induce Spemann organizer cells and induce axis formation. The unprocessed protein antagonizes bmp-signaling ().
 nodal3-b ELISA Kit
 nodal3-b Recombinant
 nodal3-b Antibody
 fug ELISA Kit
 fug Recombinant
 fug Antibody
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Nodal homolog 3-C

 Nodal homolog 3-C ELISA Kit
 Nodal homolog 3-C Recombinant
 Nodal homolog 3-C Antibody
Also known as Nodal homolog 3-C (Nodal-related protein 3-C) (Xtnr3-C).
Exhibits mesoderm-dorsalizing activity and neural-inducing activity, but lacks mesoderm-inducing activity. Regulates the expression of specific mesodermal and neural genes. Induces convergent extension movements at the embryonic midline by activating the fgf signaling pathway to induce t/bra expression in the organizer regio
>>>
n. Acts with wnt11 to induce Spemann organizer cells and induce axis formation (). The unprocessed protein antagonizes bmp-signaling.
 nodal3-C ELISA Kit
 nodal3-C Recombinant
 nodal3-C Antibody
 nr3-C ELISA Kit
 nr3-C Recombinant
 nr3-C Antibody
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Nodal homolog 4-A

 Nodal homolog 4-A ELISA Kit
 Nodal homolog 4-A Recombinant
 Nodal homolog 4-A Antibody
Also known as Nodal homolog 4-A (Nodal-related protein 4-A) (Xnr-4) (Xnr4).
Cooperation and regulatory loops of multiple nodals are essential for mesendoderm patterning in early embryos. Plays a role in mesoderm formation and may be required for neural development.
 nodal4-a ELISA Kit
 nodal4-a Recombinant
 nodal4-a Antibody
 nr4 ELISA Kit
 nr4 Recombinant
 nr4 Antibody
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Nodal homolog 4-B

 Nodal homolog 4-B ELISA Kit
 Nodal homolog 4-B Recombinant
 Nodal homolog 4-B Antibody
Also known as Nodal homolog 4-B (Nodal-related protein 4-B) (Xnr4).
Cooperation and regulatory loops of multiple nodals are essential for mesendoderm patterning in early embryos. Plays a role in mesoderm formation and may be required for neural development ().
 nodal4-b ELISA Kit
 nodal4-b Recombinant
 nodal4-b Antibody
 nr4 ELISA Kit
 nr4 Recombinant
 nr4 Antibody
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