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NUAK family SNF1-like kinase

Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair .

Below are the list of possible NUAK family SNF1-like kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

NUAK family SNF1-like kinase 1

 NUAK family SNF1-like kinase 1 ELISA Kit
 NUAK family SNF1-like kinase 1 Recombinant
 NUAK family SNF1-like kinase 1 Antibody
Also known as NUAK family SNF1-like kinase 1 (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1).
NuaK1: a protein kinase of the CAMKL family. Phosphorylated and activated by AKT1 during glucose starvation. May activate ATM kinase under conditions of nutrient starvation. Suppresses apoptosis induced by nutrient starvation and death receptors via inhibition of caspase 8 activation.

Protein type: CAMK group; CAMKL family; EC; Kinase, protein; NuaK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 12

Cellular Component: cytoplasm; microtubule cytoskeleton; nucleolus; nucleoplasm; nucleus

Molecular Function: p53 binding; protein binding; protein serine/threonine kinase activity

Biological Process: protein amino acid phosphorylation; regulation of cell adhesion; regulation of cell proliferation
 NUAK1 Recombinant
 NUAK1 Antibody
 ARK5 Recombinant
 ARK5 Antibody
 KIAA0537 Recombinant
 KIAA0537 Antibody
 OMPHK1 Recombinant
 OMPHK1 Antibody
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NUAK family SNF1-like kinase 2

 NUAK family SNF1-like kinase 2 ELISA Kit
 NUAK family SNF1-like kinase 2 Recombinant
 NUAK family SNF1-like kinase 2 Antibody
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1 ().
 NUAK2 Recombinant
 NUAK2 Antibody
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