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Nuclear cap-binding protein

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Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary miRNA processing. In the CBC complex, ABH1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure. Involved in flowering regulation, possibly by regulating pre-mRNA splicing of FLC gene. Acts as a negative regulator of abscisic acid signaling in guard cells.

Below are the list of possible Nuclear cap-binding protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Nuclear cap-binding protein subunit 1

 Nuclear cap-binding protein subunit 1 ELISA Kit
 Nuclear cap-binding protein subunit 1 Recombinant
 Nuclear cap-binding protein subunit 1 Antibody
Also known as Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (AtCBP80) (NCBP 80 kDa subunit) (Abscisic acid-hypersensitive protein 1) (ABA-hypersensitive protein 1) (Protein ENSALADA).
Encodes a nuclear cap-binding protein that forms a heterodimeric complex with CBP20 and is involved in ABA signaling and flowering. Mutants are early flowering and exhibit hypersensitive response to ABA in germination inhibition.Loss of ABH1 function results in abnormal processing of mRNAs for several important floral regulators (FLC, CO, FLM). Analysis of loss of function mutation
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s suggests a role in pri-miRNA processing and mRNA splicing. Note that two different mutant alleles were given the same name abh1-7 (Kuhn et al 2007; Kim et al 2008). To avoid confusion, abh1-7 described in Kim et al (2008) has been renamed abh1-107 (other names: ensalada-1, ens-1).
 ABH1 ELISA Kit
 ABH1 Recombinant
 ABH1 Antibody
 CBP80 ELISA Kit
 CBP80 Recombinant
 CBP80 Antibody
 ENS ELISA Kit
 ENS Recombinant
 ENS Antibody
 At2g13540 ELISA Kit
 At2g13540 Recombinant
 At2g13540 Antibody
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Nuclear cap-binding protein subunit 1-A

 Nuclear cap-binding protein subunit 1-A ELISA Kit
 Nuclear cap-binding protein subunit 1-A Recombinant
 Nuclear cap-binding protein subunit 1-A Antibody
Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA expor
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t machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure. Associates with NCBP3 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. The conventional CBC with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus whereas the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role only in mRNA export ().
 ncbp1-a ELISA Kit
 ncbp1-a Recombinant
 ncbp1-a Antibody
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Nuclear cap-binding protein subunit 1-B

 Nuclear cap-binding protein subunit 1-B ELISA Kit
 Nuclear cap-binding protein subunit 1-B Recombinant
 Nuclear cap-binding protein subunit 1-B Antibody
Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA expor
>>>
t machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure. Associates with NCBP3 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. The conventional CBC with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus whereas the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role only in mRNA export ().
 ncbp1-b ELISA Kit
 ncbp1-b Recombinant
 ncbp1-b Antibody
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Nuclear cap-binding protein subunit 2

 Nuclear cap-binding protein subunit 2 ELISA Kit
 Nuclear cap-binding protein subunit 2 Recombinant
 Nuclear cap-binding protein subunit 2 Antibody
Also known as Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (Cell proliferation-inducing gene 55 protein) (NCBP 20 kDa subunit) (CBP20) (NCBP-interacting protein 1) (NIP1).
NCBP2: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/
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THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA- mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. Belongs to the RRM NCBP2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA splicing; RNA-binding; Spliceosome; Translation

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: cytoplasm; cytosol; mRNA cap complex; nucleoplasm; nucleus

Molecular Function: mRNA binding; protein binding; RNA 7-methylguanosine cap binding; RNA binding; snRNA binding

Biological Process: fibroblast growth factor receptor signaling pathway; gene expression; histone mRNA metabolic process; mRNA 3'-end processing; mRNA capping; mRNA catabolic process, nonsense-mediated decay; mRNA export from nucleus; nuclear export; nuclear mRNA cis splicing, via U2-type spliceosome; nuclear mRNA splicing, via spliceosome; positive regulation of mRNA 3'-end processing; positive regulation of RNA export from nucleus; regulation of translational initiation; RNA elongation from RNA polymerase II promoter; RNA export from nucleus; RNA splicing; snRNA export from nucleus; snRNA transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter
 NCBP2 ELISA Kit
 NCBP2 Recombinant
 NCBP2 Antibody
 CBP20 ELISA Kit
 CBP20 Recombinant
 CBP20 Antibody
 PIG55 ELISA Kit
 PIG55 Recombinant
 PIG55 Antibody
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Nuclear cap-binding protein subunit 2-A

 Nuclear cap-binding protein subunit 2-A ELISA Kit
 Nuclear cap-binding protein subunit 2-A Recombinant
 Nuclear cap-binding protein subunit 2-A Antibody
Also known as Nuclear cap-binding protein subunit 2-A (20 kDa nuclear cap-binding protein A) (NCBP 20 kDa subunit A) (CBP20-A).
Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference
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via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires Cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure ().
 Cbp20-A ELISA Kit
 Cbp20-A Recombinant
 Cbp20-A Antibody
 GJ18756 ELISA Kit
 GJ18756 Recombinant
 GJ18756 Antibody
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Nuclear cap-binding protein subunit 2B

 Nuclear cap-binding protein subunit 2B ELISA Kit
 Nuclear cap-binding protein subunit 2B Recombinant
 Nuclear cap-binding protein subunit 2B Antibody
Also known as Nuclear cap-binding protein subunit 2B (20 kDa nuclear cap-binding protein B) (NCBP 20 kDa subunit B) (CBP20-B).
Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference
>>>
via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires Cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure ().
 Cbp20-B ELISA Kit
 Cbp20-B Recombinant
 Cbp20-B Antibody
 GJ23276 ELISA Kit
 GJ23276 Recombinant
 GJ23276 Antibody
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Nuclear cap-binding protein subunit 2-like

 Nuclear cap-binding protein subunit 2-like ELISA Kit
 Nuclear cap-binding protein subunit 2-like Recombinant
 Nuclear cap-binding protein subunit 2-like Antibody
NCBP2L: Belongs to the RRM NCBP2 family.

Chromosomal Location of Human Ortholog: Xq22.3

Molecular Function: RNA cap binding

Biological Process: nuclear mRNA splicing, via spliceosome
 NCBP2L ELISA Kit
 NCBP2L Recombinant
 NCBP2L Antibody
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Nuclear cap-binding protein subunit 3

 Nuclear cap-binding protein subunit 3 ELISA Kit
 Nuclear cap-binding protein subunit 3 Recombinant
 Nuclear cap-binding protein subunit 3 Antibody
Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does no
>>>
t bind snRNA and associates only with mRNA thereby playing a role in only mRNA export.
 NCBP3 ELISA Kit
 NCBP3 Recombinant
 NCBP3 Antibody
 RCJMB04_3g9 ELISA Kit
 RCJMB04_3g9 Recombinant
 RCJMB04_3g9 Antibody
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