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Nuclear receptor

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Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development, regulates SHH gene expression, among others, to induce granule cells proliferation as well as expression of genes involved in calcium-mediated signal transduction. Regulates the circadian expression of several clock genes, including CLOCK, ARNTL/BMAL1, NPAS2 and CRY1. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Regulates genes involved in lipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 and PPARG. In liver, has specific and redundant functions with RORC as positive or negative modulator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as CYP7B1 and SULT2A1. Induces a rhythmic expression of some of these genes. In addition, interplays functionally with NR1H2 and NR1H3 for the regulation of genes involved in cholesterol metabolism. Also involved in the regulation of hepatic glucose metabolism through the modulation of G6PC and PCK1. In adipose tissue, plays a role as negative regulator of adipocyte differentiation, probably acting through dual mechanisms. May suppress CEBPB-dependent adipogenesis through direct interaction and PPARG-dependent adipogenesis through competition for DNA-binding. Downstream of IL6 and TGFB and synergistically with RORC isoform 2, is implicated in the lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. Involved in hypoxia signaling by interacting with and activating the transcriptional activity of HIF1A. May inhibit cell growth in response to cellular stress. May exert an anti-inflammatory role by inducing CHUK expression and inhibiting NF-kappa-B signaling.

Below are the list of possible Nuclear receptor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Nuclear receptor ROR-alpha

 Nuclear receptor ROR-alpha ELISA Kit
 Nuclear receptor ROR-alpha Recombinant
 Nuclear receptor ROR-alpha Antibody
Also known as Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha) (Nuclear receptor subfamily 1 group F member 1) (RAR-related orphan receptor A) (Retinoid-related orphan receptor-alpha).
RORA: Orphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence 5'-[AT][TA]A[AT][CGT]TAGGTCA-3'. Regulates a number of genes involved in lipid metabolism such as apolipoproteins AI, APOA5, CIII, CYP71 and PPARgamma, in cerebellum and photoreceptor developm
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ent including PCP2, OPN1SW, OPN1SM AND ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1. Possible receptor for cholesterol or one of its derivatives. Monomer. Interacts (via the DNA-binding domain) with HIF1; the interaction enhances HIF1A transcription under hypoxia through increasing protein stability. By hypoxia and melatonin. Widely expressed in a number of tissues. Activated by CaMK4. Belongs to the nuclear hormone receptor family. NR1 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Nuclear receptor

Cellular Component: nucleus

Molecular Function: beta-catenin binding; DNA binding; oxysterol binding; protein binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding

Biological Process: angiogenesis; cerebellar Purkinje cell differentiation; cGMP metabolic process; circadian regulation of gene expression; granule cell precursor proliferation; intracellular receptor-mediated signaling pathway; muscle cell differentiation; negative regulation of fat cell differentiation; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of inflammatory response; nitric oxide biosynthetic process; positive regulation of circadian rhythm; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of circadian rhythm; regulation of macrophage activation; regulation of smoothened signaling pathway; regulation of steroid metabolic process; regulation of transcription, DNA-dependent; xenobiotic metabolic process
 Rora ELISA Kit
 Rora Recombinant
 Rora Antibody
 Nr1f1 ELISA Kit
 Nr1f1 Recombinant
 Nr1f1 Antibody
 Rzra ELISA Kit
 Rzra Recombinant
 Rzra Antibody
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Nuclear receptor ROR-beta

 Nuclear receptor ROR-beta ELISA Kit
 Nuclear receptor ROR-beta Recombinant
 Nuclear receptor ROR-beta Antibody
Also known as Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta).
RORB: Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5'-AGGTCA-3' in the OPN1SW promoter. Belongs
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to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Nuclear receptor

Cellular Component: nucleus

Molecular Function: melatonin receptor activity; protein binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding

Biological Process: eye photoreceptor cell development; negative regulation of osteoblast differentiation; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; regulation of circadian rhythm; retinal cone cell development; retinal rod cell development
 Rorb ELISA Kit
 Rorb Recombinant
 Rorb Antibody
 Nr1f2 ELISA Kit
 Nr1f2 Recombinant
 Nr1f2 Antibody
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Nuclear receptor ROR-gamma

 Nuclear receptor ROR-gamma ELISA Kit
 Nuclear receptor ROR-gamma Recombinant
 Nuclear receptor ROR-gamma Antibody
Also known as Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Nuclear receptor subfamily 1 group F member 3) (RAR-related orphan receptor C) (Retinoid-related orphan receptor-gamma).
RORC: Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. Belongs to the n
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uclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Nuclear receptor; Transcription factor

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleoplasm; nucleus

Molecular Function: oxysterol binding; protein binding; transcription factor activity

Biological Process: circadian regulation of gene expression; positive regulation of circadian rhythm; positive regulation of transcription, DNA-dependent; regulation of fat cell differentiation; regulation of steroid metabolic process; transcription initiation from RNA polymerase II promoter; xenobiotic metabolic process

Disease: Immunodeficiency 42
 RORC ELISA Kit
 RORC Recombinant
 RORC Antibody
 NR1F3 ELISA Kit
 NR1F3 Recombinant
 NR1F3 Antibody
 RORG ELISA Kit
 RORG Recombinant
 RORG Antibody
 RZRG ELISA Kit
 RZRG Recombinant
 RZRG Antibody
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