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Nuclear receptor coactivator

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Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.

Below are the list of possible Nuclear receptor coactivator products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Nuclear receptor coactivator 1

 Nuclear receptor coactivator 1 ELISA Kit
 Nuclear receptor coactivator 1 Recombinant
 Nuclear receptor coactivator 1 Antibody
Also known as Nuclear receptor coactivator 1 (NCoA-1) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1).
SRC-1: a transcriptional coactivator for steroid and nuclear hormone receptors. A member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, and bHLH and PAS domains. Phosphorylated and activated via the mitogen-activated protein kinase pathway. Three alternatively splic
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ed isoforms have been described.

Protein type: Acetyltransferase; DNA-binding; EC 2.3.1.48; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 2p23

Cellular Component: nuclear chromatin; nucleoplasm

Molecular Function: enzyme binding; estrogen receptor binding; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; protein binding; protein N-terminus binding; transcription coactivator activity

Biological Process: bile acid and bile salt transport; cellular lipid metabolic process; cellular response to hormone stimulus; intracellular receptor-mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter by galactose; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent
 NCOA1 ELISA Kit
 NCOA1 Recombinant
 NCOA1 Antibody
 BHLHE74 ELISA Kit
 BHLHE74 Recombinant
 BHLHE74 Antibody
 SRC1 ELISA Kit
 SRC1 Recombinant
 SRC1 Antibody
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Nuclear receptor coactivator 2

 Nuclear receptor coactivator 2 ELISA Kit
 Nuclear receptor coactivator 2 Recombinant
 Nuclear receptor coactivator 2 Antibody
Also known as Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2).
SRC-2: a transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Present in a complex with CARM1 and p300. Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP. Interacts with HIF1A, NCOA1, APEX and NR3C1. Interacts with CASP8AP2. Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leuk
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emias. Inversion inv(8)(p11;q13) generates the MYST3-NCOA2 oncogene, which consists of the N-terminus part of MYST3/MOZ and the C-terminus part of NCOA2/TIF2. MYST3-NCOA2 binds to CREBBP and disrupts its function in transcription activation. Phosphorylated and potentiated by the p38 MAPK signaling cascade in vitro and in vivo.

Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 8q13.3

Cellular Component: nucleoplasm; nucleus

Molecular Function: ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; protein binding; transcription coactivator activity

Biological Process: bile acid and bile salt transport; cellular lipid metabolic process; cellular response to hormone stimulus; circadian regulation of gene expression; intracellular receptor-mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter
 NCOA2 ELISA Kit
 NCOA2 Recombinant
 NCOA2 Antibody
 BHLHE75 ELISA Kit
 BHLHE75 Recombinant
 BHLHE75 Antibody
 SRC2 ELISA Kit
 SRC2 Recombinant
 SRC2 Antibody
 TIF2 ELISA Kit
 TIF2 Recombinant
 TIF2 Antibody
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Nuclear receptor coactivator 3

 Nuclear receptor coactivator 3 ELISA Kit
 Nuclear receptor coactivator 3 Recombinant
 Nuclear receptor coactivator 3 Antibody
Also known as Nuclear receptor coactivator 3 (NCoA-3) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid recepto.
SRC-3: a histone acetyltransferase and nuclear receptor coactivator. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin
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D3 (VDR) and prostanoids (PPARs). Involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Activity is enhanced by various hormones and TNF. Acetylation by CREBBP may suppress coactivation of target genes by disrupting its association with nuclear receptors. Frequently amplified or overexpressed in breast and ovarian cancers. Five alternatively spliced isoforms have been described.

Protein type: Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 20q12

Cellular Component: cytoplasm; nuclear chromatin; nucleoplasm; nucleus

Molecular Function: histone acetyltransferase activity; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; protein binding; protein N-terminus binding; transcription coactivator activity

Biological Process: intracellular receptor-mediated signaling pathway; positive regulation of keratinocyte differentiation; positive regulation of transcription from RNA polymerase II promoter
 NCOA3 ELISA Kit
 NCOA3 Recombinant
 NCOA3 Antibody
 AIB1 ELISA Kit
 AIB1 Recombinant
 AIB1 Antibody
 BHLHE42 ELISA Kit
 BHLHE42 Recombinant
 BHLHE42 Antibody
 RAC3 ELISA Kit
 RAC3 Recombinant
 RAC3 Antibody
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Nuclear receptor coactivator 4

 Nuclear receptor coactivator 4 ELISA Kit
 Nuclear receptor coactivator 4 Recombinant
 Nuclear receptor coactivator 4 Antibody
Also known as Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ret-activating protein ELE1).
NCOA4: Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. Defects in NCOA4 are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from ot
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herwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving NCOA4 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene that has been found in sporadic and radiation-associated post-Chernobyl thyroid papillary carcinomas. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Oncoprotein

Chromosomal Location of Human Ortholog: 10q11.2

Cellular Component: nucleus

Biological Process: male gonad development; protein targeting to lysosome

Disease: Thyroid Carcinoma, Papillary
 NCOA4 ELISA Kit
 NCOA4 Recombinant
 NCOA4 Antibody
 ARA70 ELISA Kit
 ARA70 Recombinant
 ARA70 Antibody
 ELE1 ELISA Kit
 ELE1 Recombinant
 ELE1 Antibody
 RFG ELISA Kit
 RFG Recombinant
 RFG Antibody
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Nuclear receptor coactivator 5

 Nuclear receptor coactivator 5 ELISA Kit
 Nuclear receptor coactivator 5 Recombinant
 Nuclear receptor coactivator 5 Antibody
Also known as Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA).
NCOA5: Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation
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of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Cellular Component: actin cytoskeleton; extracellular space; nucleus

Molecular Function: chromatin binding

Biological Process: glucose homeostasis; negative regulation of insulin receptor signaling pathway
 Ncoa5 ELISA Kit
 Ncoa5 Recombinant
 Ncoa5 Antibody
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Nuclear receptor coactivator 6

 Nuclear receptor coactivator 6 ELISA Kit
 Nuclear receptor coactivator 6 Recombinant
 Nuclear receptor coactivator 6 Antibody
Also known as Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein).
NCOA6: a nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Ubiquitous. Highly exp
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ressed in brain, prostate, testis and ovary. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of nuclear receptors for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Interacts in vitro with the basal transcription factors TFIIA and TBP, suggesting an autonomous transactivation function. Interacts with NCOA1, CRSP3, RBM14, the histone acetyltransferases p300 and CBP, and with the methyltransferases NCOA6IP and PRMT2. Phosphorylation of S884 inhibits the binding to the ERs.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 20q11

Cellular Component: histone methyltransferase complex; intracellular membrane-bound organelle; nucleoplasm; nucleus; transcription factor complex

Molecular Function: chromatin binding; enzyme binding; estrogen receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; protein binding; retinoid X receptor binding; thyroid hormone receptor binding; transcription coactivator activity

Biological Process: brain development; cellular lipid metabolic process; heart development; myeloid cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; response to DNA damage stimulus; response to hormone stimulus; transcription initiation; transcription initiation from RNA polymerase II promoter
 NCOA6 ELISA Kit
 NCOA6 Recombinant
 NCOA6 Antibody
 AIB3 ELISA Kit
 AIB3 Recombinant
 AIB3 Antibody
 KIAA0181 ELISA Kit
 KIAA0181 Recombinant
 KIAA0181 Antibody
 RAP250 ELISA Kit
 RAP250 Recombinant
 RAP250 Antibody
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Nuclear receptor coactivator 7

 Nuclear receptor coactivator 7 ELISA Kit
 Nuclear receptor coactivator 7 Recombinant
 Nuclear receptor coactivator 7 Antibody
NCOA7: Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. Belongs to the OXR1 family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Cellular Component: intracellu
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lar

Molecular Function: ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding

Biological Process: positive regulation of transcription from RNA polymerase II promoter
 Ncoa7 ELISA Kit
 Ncoa7 Recombinant
 Ncoa7 Antibody
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