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Nuclear receptor subfamily

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Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity).

Below are the list of possible Nuclear receptor subfamily products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Nuclear receptor subfamily 0 group B member 1

 Nuclear receptor subfamily 0 group B member 1 ELISA Kit
 Nuclear receptor subfamily 0 group B member 1 Recombinant
 Nuclear receptor subfamily 0 group B member 1 Antibody
Also known as Nuclear receptor subfamily 0 group B member 1 (DSS-AHC critical region on the X chromosome protein 1) (Nuclear receptor DAX-1).
NR0B1: orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency. Homodimerizes with STF-1, NR5A2, NR0B2 and with COPS2. Shuttles betw
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een the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus. Homodimerization involved an interaction between amino and carboxy termini involving LXXLL motifs and steroid binding domain (AF-2 motif). Heterodimerizes with STF-1 and NROB2 through its N-terminal LXXLL motifs. Defects in NR0B1 are the cause of congenital X-linked adrenal hypoplasia. Two alternatively spliced human isoforms have been described.

Protein type: Nuclear receptor

Chromosomal Location of Human Ortholog: Xp21.3

Cellular Component: cytoplasm; membrane; nucleoplasm; nucleus; polysomal ribosome

Molecular Function: DNA binding; DNA hairpin binding; ligand-dependent nuclear receptor activity; protein binding; protein domain specific binding; protein homodimerization activity; RNA binding; sequence-specific DNA binding; steroid hormone receptor binding; transcription corepressor activity; transcription factor binding

Biological Process: adrenal gland development; gonad development; male gonad development; negative regulation of steroid hormone receptor signaling pathway; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; protein localization; steroid biosynthetic process; transcription initiation from RNA polymerase II promoter

Disease: 46,xy Sex Reversal 2; Adrenal Hypoplasia, Congenital
 NR0B1 ELISA Kit
 NR0B1 Recombinant
 NR0B1 Antibody
 AHC ELISA Kit
 AHC Recombinant
 AHC Antibody
 DAX1 ELISA Kit
 DAX1 Recombinant
 DAX1 Antibody
Table BarTOPTable Bar
 

Nuclear receptor subfamily 0 group B member 2

 Nuclear receptor subfamily 0 group B member 2 ELISA Kit
 Nuclear receptor subfamily 0 group B member 2 Recombinant
 Nuclear receptor subfamily 0 group B member 2 Antibody
Also known as Nuclear receptor subfamily 0 group B member 2 (Orphan nuclear receptor SHP) (Small heterodimer partner).
NR0B2: Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by
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interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1. Defects in NR0B2 may be associated with obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Belongs to the nuclear hormone receptor family. NR0 subfamily.

Protein type: Nuclear receptor; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Cellular Component: cytoplasm; nucleus; protein complex

Molecular Function: peroxisome proliferator activated receptor binding; protein complex binding; protein domain specific binding; protein homodimerization activity; retinoic acid receptor binding; retinoid X receptor binding; thyroid hormone receptor binding; transcription corepressor activity; transcription factor binding

Biological Process: negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; Notch signaling pathway; organ regeneration; positive regulation of insulin secretion; response to glucose stimulus
 Nr0b2 ELISA Kit
 Nr0b2 Recombinant
 Nr0b2 Antibody
 Shp ELISA Kit
 Shp Recombinant
 Shp Antibody
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Nuclear receptor subfamily 1 group D member 1

 Nuclear receptor subfamily 1 group D member 1 ELISA Kit
 Nuclear receptor subfamily 1 group D member 1 Recombinant
 Nuclear receptor subfamily 1 group D member 1 Antibody
Also known as Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1).
NR1D1: a widely expressed member of the orphan nuclear receptor family of proteins. Expressed at relatively high levels in adipose tissue, skeletal muscle, brain and liver, and regulates cellular proliferation and differentiation. Expression increases during differentiation in adipoc
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ytes and its ectopic expression in 3T3-L1 cells potentiates adipocyte differentiation. A metabolic regulator whose expression is increased in HER2-positive breast cancer cells. Regulates malate dehydrogenase 1 (MDH1) and malic enzyme 1 (ME1), enzymes that link glycolysis and fatty acid synthesis. May contribute to the abnormal cellular energy metabolism observed in HER2-positive breast cancers. Its expression oscillates with circadian rhythm in liver cells, regulating the expression of BMAL1, ApoA1 and ApoC3, all key regulators of circadian rhythm. Represses the basal activity of the mouse Bmal1 gene promoter. Phosphorylation by GSK3b at S55/59 stabilizes NRD1 protein levels. Regulates inflammation by targeting the NF-??B responsive genes IL-6 and COX-2. NR1D1 lacks the activation function 2 domain required for ligand-dependent activation of transcription by other members of the nuclear receptor family; thus it behaves as a constitutive repressor protein, recruiting the nuclear receptor co-repressor N-CoR1/HDAC3 complex to target genes to repress transcription.

Protein type: Nuclear receptor; Transcription factor

Cellular Component: cell soma; cytoplasm; dendrite; dendritic spine; nuclear chromatin; nucleus

Molecular Function: DNA binding; heme binding; protein binding; transcription factor activity

Biological Process: circadian regulation of gene expression; circadian rhythm; circadian thermoregulation; glycogen biosynthetic process; negative regulation of toll-like receptor 4 signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; photoperiodism; positive regulation of circadian rhythm; positive regulation of transcription, DNA-dependent; proteasomal protein catabolic process; regulation of circadian rhythm; regulation of fat cell differentiation; regulation of lipid metabolic process; regulation of transcription, DNA-dependent
 Nr1d1 ELISA Kit
 Nr1d1 Recombinant
 Nr1d1 Antibody
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Nuclear receptor subfamily 1 group D member 2

 Nuclear receptor subfamily 1 group D member 2 ELISA Kit
 Nuclear receptor subfamily 1 group D member 2 Recombinant
 Nuclear receptor subfamily 1 group D member 2 Antibody
Also known as Nuclear receptor subfamily 1 group D member 2 (EAR4) (Rev-erb-beta).
NR1D2: Binds to the sequences 5'-AATGTAGGTCA-3' and 5'- ATAACTAGGTCA-3'. Acts as a potent competitive repressor of ROR alpha function. Belongs to the nuclear hormone receptor family. NR1 subfamily.

Protein type: DNA-binding; Nuclear receptor

Cellular Component: nucleus

Molecular Function: DNA
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binding; transcription factor activity

Biological Process: lipid homeostasis; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; regulation of circadian rhythm; regulation of inflammatory response; regulation of lipid metabolic process; regulation of transcription, DNA-dependent
 Nr1d2 ELISA Kit
 Nr1d2 Recombinant
 Nr1d2 Antibody
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Nuclear receptor subfamily 1 group I member 2

 Nuclear receptor subfamily 1 group I member 2 ELISA Kit
 Nuclear receptor subfamily 1 group I member 2 Recombinant
 Nuclear receptor subfamily 1 group I member 2 Antibody
Also known as Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR).
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional
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regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]
 NR1I2 ELISA Kit
 NR1I2 Recombinant
 NR1I2 Antibody
 PXR ELISA Kit
 PXR Recombinant
 PXR Antibody
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Nuclear receptor subfamily 1 group I member 3

 Nuclear receptor subfamily 1 group I member 3 ELISA Kit
 Nuclear receptor subfamily 1 group I member 3 Recombinant
 Nuclear receptor subfamily 1 group I member 3 Antibody
Also known as Nuclear receptor subfamily 1 group I member 3 (Constitutive activator of retinoid response) (Constitutive active response) (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67).
NR1I3: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the
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phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. Interacts with ECT2. Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Directly interacts with DNAJC7. The DNAJC7-NR1I3 complex may also include HSP90. By dexamethasone. Predominantly expressed in liver. Belongs to the nuclear hormone receptor family. NR1 subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: androgen receptor activity; DNA binding; ligand-dependent nuclear receptor activity; transcription coactivator activity; transcription factor activity

Biological Process: positive regulation of transcription from RNA polymerase II promoter; signal transduction; transcription initiation from RNA polymerase II promoter
 NR1I3 ELISA Kit
 NR1I3 Recombinant
 NR1I3 Antibody
 CAR ELISA Kit
 CAR Recombinant
 CAR Antibody
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Nuclear receptor subfamily 2 group C member 1

 Nuclear receptor subfamily 2 group C member 1 ELISA Kit
 Nuclear receptor subfamily 2 group C member 1 Recombinant
 Nuclear receptor subfamily 2 group C member 1 Antibody
Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes including ESR1 and RARB. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Binds to hormone response elements (HREs) consisti
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ng of two 5'-AGGTCA-3' half site direct repeat consensus sequences (). Also activator of OCT4 gene expression. Plays a fundamental role in early embryogenesis and regulates embryonic stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation ().
 NR2C1 ELISA Kit
 NR2C1 Recombinant
 NR2C1 Antibody
Table BarTOPTable Bar
 

Nuclear receptor subfamily 2 group C member 1-A

 Nuclear receptor subfamily 2 group C member 1-A ELISA Kit
 Nuclear receptor subfamily 2 group C member 1-A Recombinant
 Nuclear receptor subfamily 2 group C member 1-A Antibody
Also known as Nuclear receptor subfamily 2 group C member 1-A (Developmental orphan receptor 2-A) (DOR2-A) (xDOR2-A) (Orphan nuclear receptor TR2-A) (Testicular receptor 2-A).
Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) con
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sisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences ().
 nr2c1-a ELISA Kit
 nr2c1-a Recombinant
 nr2c1-a Antibody
 dor2 ELISA Kit
 dor2 Recombinant
 dor2 Antibody
Table BarTOPTable Bar
 

Nuclear receptor subfamily 2 group C member 1-B

 Nuclear receptor subfamily 2 group C member 1-B ELISA Kit
 Nuclear receptor subfamily 2 group C member 1-B Recombinant
 Nuclear receptor subfamily 2 group C member 1-B Antibody
Also known as Nuclear receptor subfamily 2 group C member 1-B (Developmental orphan receptor 2-B) (DOR2-B) (xDOR2-B) (Orphan nuclear receptor TR2-B) (Testicular receptor 2-B).
Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) con
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sisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences ().
 nr2c1-b ELISA Kit
 nr2c1-b Recombinant
 nr2c1-b Antibody
 dor2 ELISA Kit
 dor2 Recombinant
 dor2 Antibody
Table BarTOPTable Bar
 

Nuclear receptor subfamily 2 group C member 2

 Nuclear receptor subfamily 2 group C member 2 ELISA Kit
 Nuclear receptor subfamily 2 group C member 2 Recombinant
 Nuclear receptor subfamily 2 group C member 2 Antibody
Also known as Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4).
NR2C2: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses
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embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior. Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. Belongs to the nuclear hormone receptor family. NR2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Nuclear receptor; Transcription factor

Cellular Component: nucleoplasm

Molecular Function: protein binding; protein heterodimerization activity; sequence-specific DNA binding; transcription factor activity

Biological Process: cerebellum development; meiotic cell cycle; positive regulation of behavior; positive regulation of embryonic development; positive regulation of myoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis
 Nr2c2 ELISA Kit
 Nr2c2 Recombinant
 Nr2c2 Antibody
 Mtr2r1 ELISA Kit
 Mtr2r1 Recombinant
 Mtr2r1 Antibody
 Tak1 ELISA Kit
 Tak1 Recombinant
 Tak1 Antibody
 Tr4 ELISA Kit
 Tr4 Recombinant
 Tr4 Antibody
Table BarTOPTable Bar
 

Nuclear receptor subfamily 2 group E member 1

 Nuclear receptor subfamily 2 group E member 1 ELISA Kit
 Nuclear receptor subfamily 2 group E member 1 Recombinant
 Nuclear receptor subfamily 2 group E member 1 Antibody
Also known as Nuclear receptor subfamily 2 group E member 1 (Nuclear receptor TLX) (Protein tailless homolog) (Tll).
Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be involved in the regulation of early eye development.
 nr2e1 ELISA Kit
 nr2e1 Recombinant
 nr2e1 Antibody
 tll ELISA Kit
 tll Recombinant
 tll Antibody
 tlx ELISA Kit
 tlx Recombinant
 tlx Antibody
Table BarTOPTable Bar
 

Nuclear receptor subfamily 2 group F member 1-A

 Nuclear receptor subfamily 2 group F member 1-A ELISA Kit
 Nuclear receptor subfamily 2 group F member 1-A Recombinant
 Nuclear receptor subfamily 2 group F member 1-A Antibody
Also known as Nuclear receptor subfamily 2 group F member 1-A (COUP transcription factor 1-A) (COUP-TFalpha-A) (zCOUP-TFI) (Seven-up related 44) (Svp[44]) (zSvp[44]) (Steroid receptor homolog SVP 44).
Putative transcription factor that is required in photoreceptor cells precursors during eye development.
 nr2f1a ELISA Kit
 nr2f1a Recombinant
 nr2f1a Antibody
 nr2f1 ELISA Kit
 nr2f1 Recombinant
 nr2f1 Antibody
 svp44 ELISA Kit
 svp44 Recombinant
 svp44 Antibody
 si:dkeyp-10a3.1 ELISA Kit
 si:dkeyp-10a3.1 Recombinant
 si:dkeyp-10a3.1 Antibody
Table BarTOPTable Bar
 

Nuclear receptor subfamily 2 group F member 1-B

 Nuclear receptor subfamily 2 group F member 1-B ELISA Kit
 Nuclear receptor subfamily 2 group F member 1-B Recombinant
 Nuclear receptor subfamily 2 group F member 1-B Antibody
Also known as Nuclear receptor subfamily 2 group F member 1-B (COUP transcription factor 1-B) (COUP-TFalpha-B).
Putative transcription factor that is required in photoreceptor cells precursors during eye development.
 nr2f1b ELISA Kit
 nr2f1b Recombinant
 nr2f1b Antibody
 nr2f1l ELISA Kit
 nr2f1l Recombinant
 nr2f1l Antibody
 zgc:77353 ELISA Kit
 zgc:77353 Recombinant
 zgc:77353 Antibody
Table BarTOPTable Bar
 

Nuclear receptor subfamily 2 group F member 5

 Nuclear receptor subfamily 2 group F member 5 ELISA Kit
 Nuclear receptor subfamily 2 group F member 5 Recombinant
 Nuclear receptor subfamily 2 group F member 5 Antibody
Also known as Nuclear receptor subfamily 2 group F member 5 (Steroid receptor homolog SVP 46).
Putative receptor that is required in photoreceptor cells precursors during eye development.
 nr2f5 ELISA Kit
 nr2f5 Recombinant
 nr2f5 Antibody
 svp46 ELISA Kit
 svp46 Recombinant
 svp46 Antibody
Table BarTOPTable Bar
 

Nuclear receptor subfamily 2 group F member 6

 Nuclear receptor subfamily 2 group F member 6 ELISA Kit
 Nuclear receptor subfamily 2 group F member 6 Recombinant
 Nuclear receptor subfamily 2 group F member 6 Antibody
Also known as Nuclear receptor subfamily 2 group F member 6 (COUP transcription factor 3) (COUP-TF3) (V-erbA-related protein 2) (EAR-2).
EAR-2: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-n
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europhysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type- specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). Belongs to the nuclear hormone receptor family. NR2 subfamily.

Protein type: DNA-binding; Nuclear receptor

Cellular Component: nucleus

Molecular Function: sequence-specific DNA binding; transcription factor activity

Biological Process: detection of temperature stimulus involved in sensory perception of pain; entrainment of circadian clock by photoperiod; negative regulation of transcription from RNA polymerase II promoter; neuron development
 Nr2f6 ELISA Kit
 Nr2f6 Recombinant
 Nr2f6 Antibody
 Ear-2 ELISA Kit
 Ear-2 Recombinant
 Ear-2 Antibody
 Ear2 ELISA Kit
 Ear2 Recombinant
 Ear2 Antibody
 Erbal2 ELISA Kit
 Erbal2 Recombinant
 Erbal2 Antibody
Table BarTOPTable Bar
 

Nuclear receptor subfamily 4 group A member 1

 Nuclear receptor subfamily 4 group A member 1 ELISA Kit
 Nuclear receptor subfamily 4 group A member 1 Recombinant
 Nuclear receptor subfamily 4 group A member 1 Antibody
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation ().
 NR4A1 ELISA Kit
 NR4A1 Recombinant
 NR4A1 Antibody
Table BarTOPTable Bar
 

Nuclear receptor subfamily 4 group A member 2

 Nuclear receptor subfamily 4 group A member 2 ELISA Kit
 Nuclear receptor subfamily 4 group A member 2 Recombinant
 Nuclear receptor subfamily 4 group A member 2 Antibody
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons ().
 NR4A2 ELISA Kit
 NR4A2 Recombinant
 NR4A2 Antibody
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Nuclear receptor subfamily 4 group A member 3

 Nuclear receptor subfamily 4 group A member 3 ELISA Kit
 Nuclear receptor subfamily 4 group A member 3 Recombinant
 Nuclear receptor subfamily 4 group A member 3 Antibody
Also known as Nuclear receptor subfamily 4 group A member 3 (Mitogen-induced nuclear orphan receptor) (Neuron-derived orphan receptor 1) (Nuclear hormone receptor NOR-1).
NR4A3: Binds to the B1A response-element. Defects in NR4A3 are a cause of Ewing sarcoma (ES). A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the n
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eural crest. Ewing sarcoma represents the less differentiated form of the tumors. A chromosomal aberration involving NR4A3 is found in patients with Erwing sarcoma. Translocation t(9;22)(q22-31;q11-12) with EWSR1. A chromosomal aberration involving NR4A3 is a cause of a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with TAF2N. Belongs to the nuclear hormone receptor family. NR4 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Nuclear receptor; Oncoprotein

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: nucleoplasm

Molecular Function: protein binding; protein homodimerization activity; protein kinase binding; thyroid hormone receptor activity

Biological Process: cellular respiration; fat cell differentiation; gastrulation; mast cell degranulation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of epithelial cell proliferation; positive regulation of fatty acid oxidation; positive regulation of mast cell cytokine production; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; pyruvate oxidation; regulation of smooth muscle cell proliferation; transcription initiation from RNA polymerase II promoter

Disease: Chondrosarcoma, Extraskeletal Myxoid
 NR4A3 ELISA Kit
 NR4A3 Recombinant
 NR4A3 Antibody
 CHN ELISA Kit
 CHN Recombinant
 CHN Antibody
 CSMF ELISA Kit
 CSMF Recombinant
 CSMF Antibody
 MINOR ELISA Kit
 MINOR Recombinant
 MINOR Antibody
Table BarTOPTable Bar
 

Nuclear receptor subfamily 5 group A member 2

 Nuclear receptor subfamily 5 group A member 2 ELISA Kit
 Nuclear receptor subfamily 5 group A member 2 Recombinant
 Nuclear receptor subfamily 5 group A member 2 Antibody
Also known as Nuclear receptor subfamily 5 group A member 2 (Alpha-1-fetoprotein transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Hepatocytic transcription factor) (Liver receptor homolog 1) (LRH-1).
NR5A2: Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A)
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expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Belongs to the nuclear hormone receptor family. NR5 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Nuclear receptor; Transcription factor

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: chromatin binding; DNA binding; ligand-dependent nuclear receptor activity; phospholipid binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription factor activity

Biological Process: embryonic development; hormone-mediated signaling; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of viral genome replication; regulation of transcription, DNA-dependent; tissue development; transcription initiation from RNA polymerase II promoter
 NR5A2 ELISA Kit
 NR5A2 Recombinant
 NR5A2 Antibody
 B1F ELISA Kit
 B1F Recombinant
 B1F Antibody
 CPF ELISA Kit
 CPF Recombinant
 CPF Antibody
 FTF ELISA Kit
 FTF Recombinant
 FTF Antibody
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Nuclear receptor subfamily 6 group A member 1

 Nuclear receptor subfamily 6 group A member 1 ELISA Kit
 Nuclear receptor subfamily 6 group A member 1 Recombinant
 Nuclear receptor subfamily 6 group A member 1 Antibody
Also known as Nuclear receptor subfamily 6 group A member 1 (Germ cell nuclear factor) (GCNF).
Probable orphan nuclear receptor. Binds to a response element containing repeats of the motif 5'-AGGTCA-3'. Required for anterior-posterior patterning during organogenesis. Acts with chordin to play a role in patterning the midbrain-hindbrain. Isoform Em is required for integrin-mediated cell matrix interaction during neurulation and for the morphogenetic movements leading to formation of the neural tube. Also mediates the effect of retinoic acid on primary neurogenesis ().
 nr6a1 ELISA Kit
 nr6a1 Recombinant
 nr6a1 Antibody
 gcnf ELISA Kit
 gcnf Recombinant
 gcnf Antibody
 TNeu077g24.1 ELISA Kit
 TNeu077g24.1 Recombinant
 TNeu077g24.1 Antibody
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Nuclear receptor subfamily 6 group A member 1-A

 Nuclear receptor subfamily 6 group A member 1-A ELISA Kit
 Nuclear receptor subfamily 6 group A member 1-A Recombinant
 Nuclear receptor subfamily 6 group A member 1-A Antibody
Also known as Nuclear receptor subfamily 6 group A member 1-A (Germ cell nuclear factor A) (GCNF-A) (zfGCNF).
Probable orphan nuclear receptor. Binds to a response element containing repeats of the motif 5'-AGGTCA-3' ().
 nr6a1a ELISA Kit
 nr6a1a Recombinant
 nr6a1a Antibody
 gcnf ELISA Kit
 gcnf Recombinant
 gcnf Antibody
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Nuclear receptor subfamily 6 group A member 1-B

 Nuclear receptor subfamily 6 group A member 1-B ELISA Kit
 Nuclear receptor subfamily 6 group A member 1-B Recombinant
 Nuclear receptor subfamily 6 group A member 1-B Antibody
Also known as Nuclear receptor subfamily 6 group A member 1-B (Germ cell nuclear factor B) (GCNF-B).
Probable orphan nuclear receptor. Binds to a response element containing repeats of the motif 5'-AGGTCA-3' ().
 nr6a1b ELISA Kit
 nr6a1b Recombinant
 nr6a1b Antibody
 gcnf ELISA Kit
 gcnf Recombinant
 gcnf Antibody
 si:ch211-167p9.1 ELISA Kit
 si:ch211-167p9.1 Recombinant
 si:ch211-167p9.1 Antibody
 zgc:114189 ELISA Kit
 zgc:114189 Recombinant
 zgc:114189 Antibody
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Proteins Root Name Listing
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