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Nucleolar RNA helicase

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RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes. In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes. Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77'. Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase). Involved in rRNA processing.

Below are the list of possible Nucleolar RNA helicase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Nucleolar RNA helicase 2

 Nucleolar RNA helicase 2 ELISA Kit
 Nucleolar RNA helicase 2 Recombinant
 Nucleolar RNA helicase 2 Antibody
Also known as Nucleolar RNA helicase 2 (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu).
DDX21: a protein of the DEAD box helicase family. Unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. DEAD box proteins, characterized by th
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e conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly.

Protein type: EC 3.6.4.13; Helicase; Nucleolus; RNA processing; RNA-binding

Cellular Component: membrane; nucleolus; nucleus

Molecular Function: ATP-dependent RNA helicase activity; double-stranded RNA binding; protein binding; RNA binding; RNA helicase activity; rRNA binding; snoRNA binding

Biological Process: osteoblast differentiation; response to exogenous dsRNA; response to virus; RNA secondary structure unwinding; transcription from RNA polymerase II promoter
 Ddx21 ELISA Kit
 Ddx21 Recombinant
 Ddx21 Antibody
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Nucleolar RNA helicase 2-A

 Nucleolar RNA helicase 2-A ELISA Kit
 Nucleolar RNA helicase 2-A Recombinant
 Nucleolar RNA helicase 2-A Antibody
Also known as Nucleolar RNA helicase 2-A (DEAD box protein 21-A) (Gu-alpha-A) (Nucleolar RNA helicase Gu-A) (xGu-1) (Nucleolar RNA helicase II-A) (RH II/Gu-A).
RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (). Binds various RNAs, such as rRNAs, snoRNAs
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, 7SK and, at lower extent, mRNAs (). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification (PubMed:12851405) (Probable). Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes ().
 ddx21-a ELISA Kit
 ddx21-a Recombinant
 ddx21-a Antibody
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Nucleolar RNA helicase 2-B

 Nucleolar RNA helicase 2-B ELISA Kit
 Nucleolar RNA helicase 2-B Recombinant
 Nucleolar RNA helicase 2-B Antibody
Also known as Nucleolar RNA helicase 2-B (DEAD box protein 21-B) (Gu-alpha-B) (Nucleolar RNA helicase Gu-B) (xGu-2) (Nucleolar RNA helicase II-B) (RH II/Gu-B).
RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (). Binds various RNAs, such as rRNAs, snoRNAs
>>>
, 7SK and, at lower extent, mRNAs (). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification (PubMed:12851405) (Probable). Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes ().
 ddx21-b ELISA Kit
 ddx21-b Recombinant
 ddx21-b Antibody
 ddx21 ELISA Kit
 ddx21 Recombinant
 ddx21 Antibody
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