Nucleoporin

eat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). AMO1 is specifically important for nuclear protein and mRNA export.

n the nucleus, with GDP in the cytoplasm). May have a mitosis control function ().

zed to the core of the NPC and the distal ring of the nuclear basket, is required for de novo assembly of NPCs. It is involved in nuclear GSP1 import.

ed by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NSP1 plays an important role in several nuclear transport pathways including poly(A)+ RNA, tRNA, pre-ribosome, signal recognition particle (SRP), and protein transport.

the nucleus, with GDP in the cytoplasm). As one of the FG repeat nucleoporins NUP1 is involved in interactions with and guidance of nuclear transport receptors such as SRP1-KAP95 (importin alpha and beta) through the NPC. Like the closely related NUP2 it also plays an important role in disassembling and recycling SRP1-KAP95 to the cytoplasm after nuclear import. Upon entry of the heterotrimeric SRP1-KAP95-cargo complex in the nucleus, NUP1 binds through its C-terminus to KAP95, thus accelerating the release of KAP95 and, indirectly, of the nuclear localization signal (NLS)-containing cargo from the SRP1-KAP95-cargo complex.

nantly with GTP in the nucleus, with GDP in the cytoplasm). NUP100 plays an important role in several nuclear export and import pathways including poly(A)+ RNA and protein transport.

nantly with GTP in the nucleus, with GDP in the cytoplasm). NUP116 plays an important role in several nuclear export and import pathways including poly(A)+ RNA, tRNA, pre-ribosome, and protein transport.

ort, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelope organization.

repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope. NUP145 is autocatalytically cleaved in vivo in 2 polypeptides which assume different functions in the NPC. NUP145N as one of the FG repeat nucleoporins participates in karyopherin interactions and contains part of the autocatalytic cleavage activity. NUP145C as part of the NUP84 complex is involved in nuclear poly(A)+ RNA and tRNA export.

repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.

repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm).

P in the nucleus, with GDP in the cytoplasm). NUP159 plays an important role in several nuclear export pathways including poly(A)+ RNA, pre-ribosome, and protein export.

repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.

anization.

repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.

s essential for de novo assembly of NPCs.

GTP in the nucleus, with GDP in the cytoplasm). As one of the FG repeat nucleoporins NUP2 is involved in interactions with and guidance of nuclear transport receptors such as SRP1-KAP95 (importin alpha and beta) through the NPC. Like the closely related NUP1 it also plays an important role in disassembling and recycling SRP1-KAP95 to the cytoplasm after nuclear import. Upon entry of the heterotrimeric SRP1-KAP95-cargo complex in the nucleus, NUP2 binds through its N-terminus to the SRP1 nuclear localization signal (NLS) binding site, thus accelerating the release of the NLS-cargo. SRP1 in turn is released from NUP2 by binding of the GSP1-GTP associated export factor CSE1. NUP2 may also have a chromatin boundary/insulator activity through indirect interaction with genomic DNA via CSE1 and blocking of heterochromatin spreading.

repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.

epeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm).

in the nucleus, with GDP in the cytoplasm). NUP42 is specifically important for nuclear protein and mRNA export.

regulation; Nucleoporin

Cellular Component: kinetochore

epeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.

epeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.

epeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP49 plays an important role in several nuclear transport pathways including poly(A)+ RNA, tRNA, and pre-ribosome transport.

ly with GTP in the nucleus, with GDP in the cytoplasm). NUP49 plays an important role in several nuclear transport pathways including poly(A)+ RNA, tRNA, and pre-ribosome transport.

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Cellular Component: intermediate filament cytoskeleton; intracellular membrane-bound organelle; nuclear envelope; nuclear membrane; nucleoplasm; plasma membrane

Molecular Function: nucleocytoplasmic transporter activity; phospholipid binding; protein binding; single-stranded DNA binding

Biological Process: mitotic nuclear envelope disassembly; mRNA export from nucleus; NLS-bearing substrate import into nucleus; nuclear pore organization and biogenesis; protein sumoylation; regulation of transcription, DNA-dependent; RNA-mediated gene silencing; tRNA export from nucleus; viral reproduction; viral transcription

epeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm).

in the nucleus, with GDP in the cytoplasm). NUP57 plays an important role in several nuclear transport pathways including poly(A)+ RNA, tRNA, and pre-ribosome transport.

epeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope ().

epeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope. May play a role in mitotic spindle formation and/or function.

and distribution, as well as in nuclear envelope organization.

repeats. Three isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear import; Nucleoporin

Cellular Component: nuclear envelope; nuclear pore; protein complex

Molecular Function: nuclear localization sequence binding; nucleocytoplasmic transporter activity

Biological Process: nucleocytoplasmic transport; protein heterooligomerization; protein heterotetramerization; protein homooligomerization; protein import into nucleus; regulation of protein import into nucleus

ment of the Nup107-160 subcomplex to the kinetochore ().

ment of the Nup107-160 subcomplex to the kinetochore ().