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Nucleotide-binding oligomerization domain-containing protein

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Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.

Below are the list of possible Nucleotide-binding oligomerization domain-containing protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Nucleotide-binding oligomerization domain-containing protein 1

 Nucleotide-binding oligomerization domain-containing protein 1 ELISA Kit
 Nucleotide-binding oligomerization domain-containing protein 1 Recombinant
 Nucleotide-binding oligomerization domain-containing protein 1 Antibody
Also known as Nucleotide-binding oligomerization domain-containing protein 1 (Caspase recruitment domain-containing protein 4).
NOD1: Enhances caspase-9-mediated apoptosis. Induces NF-kappa- B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effec
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tors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Homodimer. Self-associates. Binds to caspase-9 and RIPK2 by CARD-CARD interaction. Interacts with ARHGEF2. Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon.

Chromosomal Location of Human Ortholog: 7p14.3

Cellular Component: basolateral plasma membrane; cytoplasm; cytosol

Molecular Function: CARD domain binding; caspase activator activity; identical protein binding; peptidoglycan binding; protein binding; protein homodimerization activity

Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; caspase activation; defense response; defense response to bacterium; detection of bacterium; detection of biotic stimulus; inflammatory response; interleukin-8 biosynthetic process; JNK cascade; positive regulation of caspase activity; positive regulation of dendritic cell antigen processing and presentation; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein oligomerization; signal transduction
 NOD1 ELISA Kit
 NOD1 Recombinant
 NOD1 Antibody
 CARD4 ELISA Kit
 CARD4 Recombinant
 CARD4 Antibody
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Nucleotide-binding oligomerization domain-containing protein 2

 Nucleotide-binding oligomerization domain-containing protein 2 ELISA Kit
 Nucleotide-binding oligomerization domain-containing protein 2 Recombinant
 Nucleotide-binding oligomerization domain-containing protein 2 Antibody
Also known as Nucleotide-binding oligomerization domain-containing protein 2 (Caspase recruitment domain-containing protein 15).
Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering a
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ctivation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages.
 NOD2 ELISA Kit
 NOD2 Recombinant
 NOD2 Antibody
 CARD15 ELISA Kit
 CARD15 Recombinant
 CARD15 Antibody
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