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Nucleotide triphosphate diphosphatase

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May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP .

Below are the list of possible Nucleotide triphosphate diphosphatase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Nucleotide triphosphate diphosphatase NUDT15

 Nucleotide triphosphate diphosphatase NUDT15 ELISA Kit
 Nucleotide triphosphate diphosphatase NUDT15 Recombinant
 Nucleotide triphosphate diphosphatase NUDT15 Antibody
Also known as Nucleotide triphosphate diphosphatase NUDT15 (MutT homolog 2) (mMTH2) (Nucleoside diphosphate-linked moiety X motif 15) (Nudix motif 15) (Nucleoside diphosphate-linked to another moiety X hydrolase 15) (Nudix hydrolase 15).
NUDT15: Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damag
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ed form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear. May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA. Belongs to the Nudix hydrolase family.

Protein type: EC 3.6.1.55; Hydrolase

Cellular Component: cytosol

Molecular Function: 8-oxo-7,8-dihydroguanine triphosphatase activity; nucleoside-diphosphatase activity; nucleoside-triphosphate diphosphatase activity

Biological Process: dGTP catabolic process; exogenous drug catabolic process; mitotic cell cycle; purine deoxyribonucleoside triphosphate catabolic process; purine nucleotide catabolic process; response to reactive oxygen species
 Nudt15 ELISA Kit
 Nudt15 Recombinant
 Nudt15 Antibody
 Mth2 ELISA Kit
 Mth2 Recombinant
 Mth2 Antibody
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