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Nucleus accumbens-associated protein

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Functions as a transcriptional repressor. Isoform 1 is a stronger transcriptional repressor than isoform 2. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.

Below are the list of possible Nucleus accumbens-associated protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Nucleus accumbens-associated protein 1

 Nucleus accumbens-associated protein 1 ELISA Kit
 Nucleus accumbens-associated protein 1 Recombinant
 Nucleus accumbens-associated protein 1 Antibody
Also known as Nucleus accumbens-associated protein 1 (NAC-1) (BTB/POZ domain-containing protein 14B).
NAC1: Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. Homooligomer; mediated by the BTB domain. Interacts with HDAC3 and HD
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AC4. Interacts (via BTB domain) with CUL3, PSMD7 AND RCOR1. Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer.

Protein type: Transcription factor

Cellular Component: nuclear body; nucleus

Molecular Function: protein binding

Biological Process: negative regulation of transcription, DNA-dependent; positive regulation of cell proliferation; protein homooligomerization
 Nacc1 ELISA Kit
 Nacc1 Recombinant
 Nacc1 Antibody
 Btbd14b ELISA Kit
 Btbd14b Recombinant
 Btbd14b Antibody
 Nac1 ELISA Kit
 Nac1 Recombinant
 Nac1 Antibody
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Nucleus accumbens-associated protein 2

 Nucleus accumbens-associated protein 2 ELISA Kit
 Nucleus accumbens-associated protein 2 Recombinant
 Nucleus accumbens-associated protein 2 Antibody
Also known as Nucleus accumbens-associated protein 2 (NAC-2) (BTB/POZ domain-containing protein 14A).
BTBD14A: Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. Homooligomer; mediated by the BTB domain. Interacts with the
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NuRD complex. Interacts (via C-terminal part) with HDAC2. Interacts (via BTB domain) with MTA1, MTA2 and MTA3

Cellular Component: nuclear chromatin; nucleus; NuRD complex

Molecular Function: histone deacetylase activity; histone deacetylase binding; protein homodimerization activity

Biological Process: negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; protein homooligomerization
 Nacc2 ELISA Kit
 Nacc2 Recombinant
 Nacc2 Antibody
 Btbd14a ELISA Kit
 Btbd14a Recombinant
 Btbd14a Antibody
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