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O-methyltransferase

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CATALYTIC ACTIVITY: S-adenosyl-L-methionine + 3,5-dichloro-2,4,6-trihydroxyphenyl = S-adenosyl-L-homocysteine + 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one.

Below are the list of possible O-methyltransferase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

O-methyltransferase 10

 O-methyltransferase 10 ELISA Kit
 O-methyltransferase 10 Recombinant
 O-methyltransferase 10 Antibody
 omt10 ELISA Kit
 omt10 Recombinant
 omt10 Antibody
 DDB_G0290719 ELISA Kit
 DDB_G0290719 Recombinant
 DDB_G0290719 Antibody
Table BarTOPTable Bar
 

O-methyltransferase 12

 O-methyltransferase 12 ELISA Kit
 O-methyltransferase 12 Recombinant
 O-methyltransferase 12 Antibody
S-adenosyl-L-methionine dependent O-methyltransferase that may be involved in modifying resorcinol ring to synthesize a variant of 4-methyl-5-pentylbenzene-1,3-diol.
 omt12 ELISA Kit
 omt12 Recombinant
 omt12 Antibody
 DDB_G0293888 ELISA Kit
 DDB_G0293888 Recombinant
 DDB_G0293888 Antibody
Table BarTOPTable Bar
 

O-methyltransferase 2

 O-methyltransferase 2 ELISA Kit
 O-methyltransferase 2 Recombinant
 O-methyltransferase 2 Antibody
 omt2 ELISA Kit
 omt2 Recombinant
 omt2 Antibody
 DDB_G0274941 ELISA Kit
 DDB_G0274941 Recombinant
 DDB_G0274941 Antibody
Table BarTOPTable Bar
 

O-methyltransferase 3

 O-methyltransferase 3 ELISA Kit
 O-methyltransferase 3 Recombinant
 O-methyltransferase 3 Antibody
Probable methyltransferase.
 omt3 ELISA Kit
 omt3 Recombinant
 omt3 Antibody
 DDB_G0274197 ELISA Kit
 DDB_G0274197 Recombinant
 DDB_G0274197 Antibody
Table BarTOPTable Bar
 

O-methyltransferase 4

 O-methyltransferase 4 ELISA Kit
 O-methyltransferase 4 Recombinant
 O-methyltransferase 4 Antibody
 omt4 ELISA Kit
 omt4 Recombinant
 omt4 Antibody
 DDB_G0275013 ELISA Kit
 DDB_G0275013 Recombinant
 DDB_G0275013 Antibody
Table BarTOPTable Bar
 

O-methyltransferase 7

 O-methyltransferase 7 ELISA Kit
 O-methyltransferase 7 Recombinant
 O-methyltransferase 7 Antibody
 omt7 ELISA Kit
 omt7 Recombinant
 omt7 Antibody
 DDB_G0282591 ELISA Kit
 DDB_G0282591 Recombinant
 DDB_G0282591 Antibody
Table BarTOPTable Bar
 

O-methyltransferase 9

 O-methyltransferase 9 ELISA Kit
 O-methyltransferase 9 Recombinant
 O-methyltransferase 9 Antibody
 omt9 ELISA Kit
 omt9 Recombinant
 omt9 Antibody
 DDB_G0289823 ELISA Kit
 DDB_G0289823 Recombinant
 DDB_G0289823 Antibody
Table BarTOPTable Bar
 

O-methyltransferase af390-400

 O-methyltransferase af390-400 ELISA Kit
 O-methyltransferase af390-400 Recombinant
 O-methyltransferase af390-400 Antibody
Also known as O-methyltransferase af390-400 (Fumagillin biosynthesis methyltransferase) (Fma-MT).
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of fumagillin, a meroterpenoid that has numerous biological activities including irreversible inhibition of human type 2 methionine aminopeptidase (METAP2) (PubMed:23488861, PubMed:24568283). The pathway begins with the conversion of farnesyl pyrophosphate (FPP) to beta-trans-bergamotene by the membrane-bound beta-trans-bergamotene synthase af520 (PubMed:23488861). The initial oxidation of beta-trans-bergamotene by the
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multifunctional cytochrome P450 monooxygenase af510 involves C-H hydroxylation at the bridgehead C5 position to yield 5R-hydroxyl-beta-trans-bergamotene (PubMed:24568283). Subsequently, a four electron oxidation initiated at C-9 coupled to cleavage of the cyclobutane C5-C8 bond of the bicyclo[3.1.1] core yields the epoxyketone intermediate 5-keto-cordycol (PubMed:24568283). An additional epoxidation reaction also catalyzed by af510 then furnishes the characteristic bisepoxide ketone 5-keto-demethoxyfumagillol (PubMed:24568283). 5-keto-demethoxyfumagillol is then subjected to successive C-6 hydroxylation and O-methylation by the dioxygenase af480 and O-methyltransferase af390-400, respectively, to yield 5-keto-fumagillol, which is then stereoselectively reduced by the keto-reductase af490 to 5R-hydroxy-seco-sesquiterpene (PubMed:24568283). The next step is the polyketide transferase af380-catalyzed transfer of a dodecapentaenoyl group synthesized by the polyketide synthase af370 onto 5R-hydroxy-seco-sesquiterpene which leads to the production of prefumagillin (PubMed:24568283). Finally, oxidative cleavage by the monooxygenase af470 converts prefumagillin to fumagillin (PubMed:24568283).
 af390-400 ELISA Kit
 af390-400 Recombinant
 af390-400 Antibody
 fmaD ELISA Kit
 fmaD Recombinant
 fmaD Antibody
 AFUA_8G00390/400 ELISA Kit
 AFUA_8G00390/400 Recombinant
 AFUA_8G00390/400 Antibody
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O-methyltransferase afvC

 O-methyltransferase afvC ELISA Kit
 O-methyltransferase afvC Recombinant
 O-methyltransferase afvC Antibody
Also known as O-methyltransferase afvC (Aflavarin synthesis protein C).
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of aflavarin, a bicoumarin that exhibits anti-insectan activity against the fungivorous beetle C.hemipterus (Ref. 2, PubMed:26209694).
 afvC ELISA Kit
 afvC Recombinant
 afvC Antibody
 AFLA_108560 ELISA Kit
 AFLA_108560 Recombinant
 AFLA_108560 Antibody
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O-methyltransferase apf6

 O-methyltransferase apf6 ELISA Kit
 O-methyltransferase apf6 Recombinant
 O-methyltransferase apf6 Antibody
Also known as O-methyltransferase apf6 (Apicidin F synthesis protein 6).
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of the cyclic tetrapeptide apicidin F (APF) (PubMed:25058475). The non-ribosomal peptide synthetase apf1 incorporates four different amino acids to produce apicidin F: L-phenylalanine, D-pipecolic acid (D-pip), N-methoxy-L-tryptophan and L-2-amino
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octanedioic acid (PubMed:25058475). L-Phenylalanine is the only proteinogenic amino acid directly used by apf1 (PubMed:24195442, PubMed:25058475). The 3 other apf1 substrates are non-proteinogenic and have to be modified by other enzymes of the cluster (PubMed:25058475). Lysine is converted to delta-1-pyrroline-5-carboxylate (P5C) which is reduced to L-pipecolic acid (L-pip) by apf3 (PubMed:25058475). L-pip is epimerized to D-pip, probably by apf1 activity, prior to incorporation (PubMed:25058475). L-Tryptophan is N-oxidyzed by one of the cytochrome P450 monooxygenases (apf7 or apf8), and further methylated at the hydroxy group by the O-methyltransferase apf6 to yield N-methoxy-L-tryptophan (PubMed:25058475). The synthesis of the fourth apf1 substrate is more complex (PubMed:25058475). The fatty acid synthase apf5 is involved in the synthesis of the octanoic acid backbone of L-2-aminooctanedioic acid by fixing one acetyl-CoA unit and three malonyl-CoA units (PubMed:25058475). Then one of the cytochrome P450 monooxygenases (apf7 or apf8) may oxidize this backbone to 2-oxooctanoic acid (PubMed:25058475). The aminotransferase apf4 is predicted to catalyze the exchange of the keto group with an amino group (PubMed:25058475). The next step would be the oxidation of 2-aminooctanoic acid by one of the cytochrome P450 monooxygenases (apf7 or apf8). The last step is the oxidation of 2-amino-8-hydroxyoctanoic acid to 2-aminooctanedioic acid is catalyzed by the FAD-dependent monooxygenase apf9 (PubMed:25058475).
 apf6 ELISA Kit
 apf6 Recombinant
 apf6 Antibody
 FFUJ_00008 ELISA Kit
 FFUJ_00008 Recombinant
 FFUJ_00008 Antibody
Table BarTOPTable Bar
 

O-methyltransferase asqD

 O-methyltransferase asqD ELISA Kit
 O-methyltransferase asqD Recombinant
 O-methyltransferase asqD Antibody
Also known as O-methyltransferase asqD (4'-methoxyviridicatin/aspoquinolone biosynthesis cluster protein asqD) (Aspoquinolone biosynthesis protein D).
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of the aspoquinolone mycotoxins (PubMed:25251934). The first stage is catalyzed by the nonribosomal pepdide synthetase asqK that condenses anthranilic acid and O-methyl-
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L-tyrosine to produce 4'-methoxycyclopeptin (PubMed:25251934). AsqK is also able to use anthranilic acid and L-phenylalanine as substrates to produce cyclopeptin, but at a tenfold lower rate (PubMed:25251934). 4'-methoxycyclopeptin is then converted to 4'-methoxydehydrocyclopeptin by the ketoglutarate-dependent dioxygenase asqJ through dehydrogenation to form a double bond between C-alpha and C-beta of the O-methyltyrosine side chain (PubMed:25251934). AsqJ also converts its first product 4'-methoxydehydrocyclopeptin to 4'-methoxycyclopenin (PubMed:25251934). AsqJ is a very unique dioxygenase which is capable of catalyzing radical-mediated dehydrogenation and epoxidation reactions sequentially on a 6,7-benzo-diazepinedione substrate in the 4'-methoxyviridicatin biosynthetic pathway (PubMed:25251934). The following conversion of 4'-methoxycyclopenin into 4'-methoxyviridicatin proceeds non-enzymatically (PubMed:25251934). AsqJ is also capable of converting cyclopeptin into dehydrocyclopeptin and cyclopenin in a sequential fashion (PubMed:25251934). Cyclopenin can be converted into viridicatin non-enzymatically (PubMed:25251934). 4'-methoxyviridicatin likely acts as a precursor of quinolone natural products, such as aspoquinolones, peniprequinolones, penigequinolones, and yaequinolones (PubMed:25251934). Further characterization of the remaining genes in the cluster has still to be done to determine the exact identity of quinolone products this cluster is responsible for biosynthesizing (PubMed:25251934).
 asqD ELISA Kit
 asqD Recombinant
 asqD Antibody
 AN9233 ELISA Kit
 AN9233 Recombinant
 AN9233 Antibody
Table BarTOPTable Bar
 

O-methyltransferase asqN

 O-methyltransferase asqN ELISA Kit
 O-methyltransferase asqN Recombinant
 O-methyltransferase asqN Antibody
Also known as O-methyltransferase asqN (4'-methoxyviridicatin/aspoquinolone biosynthesis cluster protein asqN) (Aspoquinolone biosynthesis protein N).
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of the aspoquinolone mycotoxins (PubMed:25251934). The first stage is catalyzed by the nonribosomal pepdide synthetase asqK that condenses anthranilic acid and O-methyl-
>>>
L-tyrosine to produce 4'-methoxycyclopeptin (PubMed:25251934). AsqK is also able to use anthranilic acid and L-phenylalanine as substrates to produce cyclopeptin, but at a tenfold lower rate (PubMed:25251934). 4'-methoxycyclopeptin is then converted to 4'-methoxydehydrocyclopeptin by the ketoglutarate-dependent dioxygenase asqJ through dehydrogenation to form a double bond between C-alpha and C-beta of the O-methyltyrosine side chain (PubMed:25251934). AsqJ also converts its first product 4'-methoxydehydrocyclopeptin to 4'-methoxycyclopenin (PubMed:25251934). AsqJ is a very unique dioxygenase which is capable of catalyzing radical-mediated dehydrogenation and epoxidation reactions sequentially on a 6,7-benzo-diazepinedione substrate in the 4'-methoxyviridicatin biosynthetic pathway (PubMed:25251934). The following conversion of 4'-methoxycyclopenin into 4'-methoxyviridicatin proceeds non-enzymatically (PubMed:25251934). AsqJ is also capable of converting cyclopeptin into dehydrocyclopeptin and cyclopenin in a sequential fashion (PubMed:25251934). Cyclopenin can be converted into viridicatin non-enzymatically (PubMed:25251934). 4'-methoxyviridicatin likely acts as a precursor of quinolone natural products, such as aspoquinolones, peniprequinolones, penigequinolones, and yaequinolones (PubMed:25251934). Further characterization of the remaining genes in the cluster has still to be done to determine the exact identity of quinolone products this cluster is responsible for biosynthesizing (PubMed:25251934).
 asqN ELISA Kit
 asqN Recombinant
 asqN Antibody
 AN9223 ELISA Kit
 AN9223 Recombinant
 AN9223 Antibody
Table BarTOPTable Bar
 

O-methyltransferase bik3

 O-methyltransferase bik3 ELISA Kit
 O-methyltransferase bik3 Recombinant
 O-methyltransferase bik3 Antibody
Also known as O-methyltransferase bik3 (Bikaverin biosynthesis protein 3).
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin (PubMed:19400779). The first stage is catalyzed by the polyketide synthase bik1, which catalyzes the formation of the intermediate SMA76a also knowm as pre-bikaverin (PubMed:1940
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0779). FAD-dependent monooxygenase bik2 might then be responsible for the oxidation of pre-bikaverin to oxo-pre-bikaverin which is in turn methylated by the O-methyltransferase bik3 to me-oxo-pre-bikaverin (PubMed:26382642). A further cycle of oxydation and methylation by bik2 and bik3 leads to the final product of bikaverin, via a nor-bikaverin intermediate (PubMed:19400779, PubMed:26382642).
 bik3 ELISA Kit
 bik3 Recombinant
 bik3 Antibody
 FFUJ_06744 ELISA Kit
 FFUJ_06744 Recombinant
 FFUJ_06744 Antibody
Table BarTOPTable Bar
 

O-methyltransferase gedA

 O-methyltransferase gedA ELISA Kit
 O-methyltransferase gedA Recombinant
 O-methyltransferase gedA Antibody
Also known as O-methyltransferase gedA (Geodin synthesis protein A).
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of geodin, an intermediate in the biosynthesis of other natural products (PubMed:7665560, PubMed:19549600, PubMed:24009710). The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) gedC (PubMed:12536215, PubMed
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:19549600). The atrochrysone carboxyl ACP thioesterase gedB then breaks the thioester bond and releases the atrochrysone carboxylic acid from gedC (PubMed:19549600). The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodinanthrone (PubMed:24009710). The next step is performed by the emodinanthrone oxygenase gedH that catalyzes the oxidation of emodinanthrone to emodin (PubMed:1810248). Emodin O-methyltransferase encoded probably by gedA then catalyzes methylation of the 8-hydroxy group of emodin to form questin (PubMed:1444712). Ring cleavage of questin by questin oxidase gedK leads to desmethylsulochrin via several intermediates including questin epoxide (PubMed:3182756). Another methylation step probably catalyzed by methyltransferase gedG leads to the formation of sulochrin which is further converted to dihydrogeodin by the sulochrin halogenase gedL (PubMed:24009710). Finally, the dihydrogeodin oxidase gedJ catalyzes the stereospecific phenol oxidative coupling reaction converting dihydrogeodin to geodin (PubMed:7665560).
 gedA ELISA Kit
 gedA Recombinant
 gedA Antibody
 ATEG_08449 ELISA Kit
 ATEG_08449 Recombinant
 ATEG_08449 Antibody
Table BarTOPTable Bar
 

O-methyltransferase gliM

 O-methyltransferase gliM ELISA Kit
 O-methyltransferase gliM Recombinant
 O-methyltransferase gliM Antibody
Also known as O-methyltransferase gliM (Gliotoxin biosynthesis protein M).
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of gliotoxin, a member of the epipolythiodioxopiperazine (ETP) class of toxins characterized by a disulfide bridged cyclic dipeptide (PubMed:15979823, PubMed:21612254). The first step in gliotoxin biosynthesis is the condensation of serine and p
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henylalanine to form the cyclo-L-phenylalanyl-L-serine diketopiperazine (DKP) by the NRPS gliP (PubMed:17154540, PubMed:21612254). GliP is also able to produce the DKP cyclo-L-tryptophanyl-L-serine, suggesting that the substrate specificity of the first adenylation (A) domain in gliP is sufficiently relaxed to accommodate both L-Phe and L-Trp (PubMed:23434416). The cytochrome P450 monooxygenase gliC has been shown to catalyze the subsequent hydroxylation of the alpha-carbon of L-Phe in cyclo-L-phenylalanyl-L-serine whereas the second cytochrome P450 enzyme, gliF, is presumably involved in the modification of the DKP side chain (PubMed:24039048, PubMed:23434416). The glutathione S-transferase (GST) gliG then forms a bis-glutathionylated biosynthetic intermediate which is responsible for the sulfurization of gliotoxin (PubMed:21513890, PubMed:21749092). This bis-glutathionylated intermediate is subsequently processed by the gamma-glutamyl cyclotransferase gliK to remove both gamma-glutamyl moieties (PubMed:22903976, PubMed:24039048). Subsequent processing via gliI yields a biosynthetic intermediate, which is N-methylated via the N-methyltransferase gliN, before the gliotoxin oxidoreductase gliT-mediated disulfide bridge closure (PubMed:20548963, PubMed:22936680, PubMed:24039048, PubMed:25062268). GliN-mediated amide methylation confers stability to ETP, damping the spontaneous formation of tri- and tetrasulfides (PubMed:25062268). Intracellular dithiol gliotoxin oxidized by gliT is subsequently effluxed by gliA (PubMed:26150413). Gliotoxin contributes to pathogenesis during invasive aspergillosis (PubMed:17601876, PubMed:18199036). In macrophages and neutrophils, gliotoxin showed inhibition of various different cell functions including cytokine production, antigen presentation, phagocytosis, and production of reactive oxygen species (PubMed:17601876).
 gliM ELISA Kit
 gliM Recombinant
 gliM Antibody
 AFUA_6G09680 ELISA Kit
 AFUA_6G09680 Recombinant
 AFUA_6G09680 Antibody
Table BarTOPTable Bar
 

O-methyltransferase gsfB

 O-methyltransferase gsfB ELISA Kit
 O-methyltransferase gsfB Recombinant
 O-methyltransferase gsfB Antibody
Also known as O-methyltransferase gsfB (Griseofulvin synthesis protein B).
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of griseofulvin, an important antifungal drug that has been in use for a long time for treating dermatophyte infections (PubMed:20534346, PubMed:23978092). The first step of the pathway is the formation of the heptaketide backbone by gsfA which
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is initiated by priming with acetyl-CoA, followed by sequential condensations of 6 malonyl-CoA units (PubMed:20534346). O-methylation at 3-OH by gsfB leads to griseophenone D which is further methylated at 9-OH by gsfC to yield griseophenone C (PubMed:23978092). Griseophenone C is then substrate of halogenase gsfI which is responsible for the regio-specific chlorination at the C13 position to form griseophenone B (PubMed:23978092). The cytochrome P450 gsfF catalyzes the coupling of orcinol and phloroglucinol rings in griseophenone B to form desmethyl-dehydrogriseofulvin A which is further methylated at 5-OH by gsfD to yield dehydrogriseofulvin (PubMed:23978092). Finally, gsfE performs stereospecific reduction of enone 18 of dehydrogriseofulvin to afford the final product griseofulvin (PubMed:23978092).
 gsfB ELISA Kit
 gsfB Recombinant
 gsfB Antibody
Table BarTOPTable Bar
 

O-methyltransferase gsfC

 O-methyltransferase gsfC ELISA Kit
 O-methyltransferase gsfC Recombinant
 O-methyltransferase gsfC Antibody
Also known as O-methyltransferase gsfC (Griseofulvin synthesis protein C).
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of griseofulvin, an important antifungal drug that has been in use for a long time for treating dermatophyte infections (PubMed:20534346, PubMed:23978092). The first step of the pathway is the formation of the heptaketide backbone by gsfA which
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is initiated by priming with acetyl-CoA, followed by sequential condensations of 6 malonyl-CoA units (PubMed:20534346). O-methylation at 3-OH by gsfB leads to griseophenone D which is further methylated at 9-OH by gsfC to yield griseophenone C (PubMed:23978092). Griseophenone C is then substrate of halogenase gsfI which is responsible for the regio-specific chlorination at the C13 position to form griseophenone B (PubMed:23978092). The cytochrome P450 gsfF catalyzes the coupling of orcinol and phloroglucinol rings in griseophenone B to form desmethyl-dehydrogriseofulvin A which is further methylated at 5-OH by gsfD to yield dehydrogriseofulvin (PubMed:23978092). Finally, gsfE performs stereospecific reduction of enone 18 of dehydrogriseofulvin to afford the final product griseofulvin (PubMed:23978092).
 gsfC ELISA Kit
 gsfC Recombinant
 gsfC Antibody
Table BarTOPTable Bar
 

O-methyltransferase gsfD

 O-methyltransferase gsfD ELISA Kit
 O-methyltransferase gsfD Recombinant
 O-methyltransferase gsfD Antibody
Also known as O-methyltransferase gsfD (Griseofulvin synthesis protein D).
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of griseofulvin, an important antifungal drug that has been in use for a long time for treating dermatophyte infections (PubMed:20534346, PubMed:23978092). The first step of the pathway is the formation of the heptaketide backbone by gsfA which
>>>
is initiated by priming with acetyl-CoA, followed by sequential condensations of 6 malonyl-CoA units (PubMed:20534346). O-methylation at 3-OH by gsfB leads to griseophenone D which is further methylated at 9-OH by gsfC to yield griseophenone C (PubMed:23978092). Griseophenone C is then substrate of halogenase gsfI which is responsible for the regio-specific chlorination at the C13 position to form griseophenone B (PubMed:23978092). The cytochrome P450 gsfF catalyzes the coupling of orcinol and phloroglucinol rings in griseophenone B to form desmethyl-dehydrogriseofulvin A which is further methylated at 5-OH by gsfD to yield dehydrogriseofulvin (PubMed:23978092). Finally, gsfE performs stereospecific reduction of enone 18 of dehydrogriseofulvin to afford the final product griseofulvin (PubMed:23978092).
 gsfD ELISA Kit
 gsfD Recombinant
 gsfD Antibody
Table BarTOPTable Bar
 

O-methyltransferase hmp5

 O-methyltransferase hmp5 ELISA Kit
 O-methyltransferase hmp5 Recombinant
 O-methyltransferase hmp5 Antibody
Also known as O-methyltransferase hmp5 (Hypothemycin biosynthesis cluster protein hpm5).
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of hypothemycin, a resorcylic acid lactone (RAL) that irreversibly inhibits a subset of protein kinases with a conserved cysteine in the ATP binding site such as human ERK2 (PubMed:18567690). The first step is performed by both PKS
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s hmp3 and hmp8 and leads to the production of 7',8'-dehydrozearalenol (DHZ) (PubMed:18567690, PubMed:20222707). The highly reducing PKS hpm8 synthesizes the reduced hexaketide (7S,11S,2E,8E)-7,11-dihydroxy-dodeca-2,8-dienoate, which is transferred downstream to the non-reducing PKS hpm3 (PubMed:20222707). Hpm3 then extends the reduced hexaketide to a nonaketide, after which regioselective cyclization and macrolactonization affords DHZ (PubMed:20222707). The next step is the conversion of DHZ into aigialomycin C and is performed by the O-methyltransferase hmp5, the FAD-binding monooxygenase hmp7, and the cytochrome P450 monooxygenase hmp1 (PubMed:18567690). The wide substrate tolerance of the hmp5 and hmp7 implies that the reactions from DHZ to aigialomycin C can occur in any order (PubMed:18567690). The steps from aigialomycin C to hypothemycin are less well established (PubMed:18567690). The FAD-linked oxidoreductase hmp9 presumably catalyzes oxidation of the C-6' hydroxyl to a ketone (PubMed:18567690). The timing of this oxidation is important, since the resulting enone functional group is a Michael acceptor that can react spontaneously with glutathione, an abundant metabolite in fungal cells (PubMed:18567690). The glutathione S-transferase hmp2 catalyzes cis-trans isomerization of the 7',8' double bond with equilibrium favoring the trans isomer (PubMed:18567690). The hpm6-encoded transporter might preferentially pump hypothemycin out of the cell relative to the trans isomer aigialomycin A. The cis-to-trans isomerization may be coupled with C-4' hydroxylation, since all known hypothemycin analogs containing the enone functional group also have hydroxyl groups at both C-4' and C-5' (PubMed:18567690).
 hpm5 ELISA Kit
 hpm5 Recombinant
 hpm5 Antibody
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O-methyltransferase MdmC

 O-methyltransferase MdmC ELISA Kit
 O-methyltransferase MdmC Recombinant
 O-methyltransferase MdmC Antibody
4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics.
 mdmC ELISA Kit
 mdmC Recombinant
 mdmC Antibody
Table BarTOPTable Bar
 

O-methyltransferase mpaG

 O-methyltransferase mpaG ELISA Kit
 O-methyltransferase mpaG Recombinant
 O-methyltransferase mpaG Antibody
Also known as O-methyltransferase mpaG (Mycophenolic acid synthesis protein G).
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world (PubMed:21398490, PubMed:22544261, PubMed:25630520). The first step of the pathway is the synthesis of 5-methylorsellinic acid (5MOA) by the polyketide s
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ynthase mpaC (PubMed:21398490). 5MOA is then converted to the phthalide compound 5,7-dihydroxy-4,6-dimethylphthalide (DHDMP) by mpaDE (PubMed:22544261). MpaDE first catalyzes hydroxylation of 5-MOA to 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoic acid (DHMB) (PubMed:22544261). MpaDE then acts as a lactone synthase that catalyzes the ring closure to convert DHMB is then converted to DHMP (PubMed:22544261). The next step is the prenylation of DHMP by the prenyltransferase mpaA to yield farnesyl-DHDMP (PubMed:25630520). Farnesyl-DHDMP might be a substrate of mpaH for transformation into demethylmycophenolic acid (DMMPA) (PubMed:25630520). Finally, the O-methyltransferase mpaG catalyzes the methylation DMMPA to form MPA (PubMed:25630520).
 mpaG ELISA Kit
 mpaG Recombinant
 mpaG Antibody
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O-methyltransferase SfmM3

 O-methyltransferase SfmM3 ELISA Kit
 O-methyltransferase SfmM3 Recombinant
 O-methyltransferase SfmM3 Antibody
O-methyltransferase that mediates the methylation of 3-hydroxy-5-methyl-L-tyrosine (3-OH-5-Me-Tyr) into 3-hydroxy-5-methyl-O-methyltyrosine (3-OH-5-Me-OMe-Tyr), a core structure of saframycin A, a potent antitumor antibiotic that belongs to the tetrahydroisoquinoline family.
 sfmM3 ELISA Kit
 sfmM3 Recombinant
 sfmM3 Antibody
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O-methyltransferase sirM

 O-methyltransferase sirM ELISA Kit
 O-methyltransferase sirM Recombinant
 O-methyltransferase sirM Antibody
Also known as O-methyltransferase sirM (Sirodesmin biosynthesis protein M).
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of sirodesmin PL, an epipolythiodioxopiperazine (ETP) characterized by a disulfide bridged cyclic dipeptide and that acts as a phytotoxin which is involved in the blackleg didease of canola (PubMed:15387811, PubMed:18272357, PubMed:19762440). S
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irD catalyzes the O-prenylation of L-tyrosine (L-Tyr) in the presence of dimethylallyl diphosphate (DMAPP) to yield 4-O-dimethylallyl-L-Tyr, and therefore represents probably the first pathway-specific enzyme in the biosynthesis of sirodesmin PL (PubMed:19762440, PubMed:21038099, PubMed:24083562). 4-O-dimethylallyl-L-Tyr, then undergoes condensation with L-Ser in a reaction catalyzed by the non-ribosomal peptide synthase sirP to form the diketopiperazine (DKP) backbone (PubMed:18272357). Further bishydroxylation of the DKP performed by the cytochrome P450 monooxygenase sirC leads to the production of the intermediate phomamide (PubMed:27390873). This step is essential to form the reactive thiol group required for toxicity of sirodesmin PL (PubMed:27390873). The next steps of sirodesmin biosynthesis are not well understood yet, but some predictions could be made from intermediate compounds identification (PubMed:18272357). Phomamide is converted into phomalizarine via oxidation, probably by sirT (PubMed:18272357). Further oxidation, methylation (by sirM or sirN) and reduction steps convert phomalizarine to deacetyl sirodesmin (PubMed:18272357). Finally, acetyltransferase sirH probably acetylates deacetyl sirodesmin to produce sirodesmin PL (PubMed:18272357).
 sirM ELISA Kit
 sirM Recombinant
 sirM Antibody
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O-methyltransferase tpcA

 O-methyltransferase tpcA ELISA Kit
 O-methyltransferase tpcA Recombinant
 O-methyltransferase tpcA Antibody
Also known as O-methyltransferase tpcA (Trypacidin synthesis protein A).
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of trypacidin, a mycotoxin with antiprotozoal activity and that plays a role in the infection process (PubMed:26278536, PubMed:26242966). The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) tpcC (PubMed:26242966). The atrochrysone carboxyl ACP thioesterase tpcB then breaks the thioester bond and releases the atrochrysone carboxylic acid from tpcC (PubMed:26242966). The decarboxylase tpcK converts at
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rochrysone carboxylic acid to atrochrysone which is further reduced into emodin anthrone (PubMed:26242966). The next step is performed by the emodin anthrone oxygenase tpcL that catalyzes the oxidation of emodinanthrone to emodin (PubMed:26242966). Emodin O-methyltransferase encoded by tpcA catalyzes methylation of the 8-hydroxy group of emodin to form questin (PubMed:26242966). Ring cleavage of questin by questin oxidase tpcI leads to desmethylsulochrin via several intermediates including questin epoxide (). Another methylation step catalyzed by tpcM leads to the formation of sulochrin which is further converted to monomethylsulfochrin by tpcH. Finally, the tpcJ catalyzes the conversion of monomethylsulfochrin to trypacidin (PubMed:26242966). Trypacidin is toxic for human pulmonary and bronchial epithelial cells by initiating the intracellular formation of nitric oxide (NO) and hydrogen peroxide (H2O2), thus triggering host necrotic cell death (PubMed:22319557). The trypacidin pathway is also able to produce endocrocin via a distinct route from the endocrocin Enc pathway (PubMed:26242966).
 tpcA ELISA Kit
 tpcA Recombinant
 tpcA Antibody
 tynA ELISA Kit
 tynA Recombinant
 tynA Antibody
 AFUA_4G14580 ELISA Kit
 AFUA_4G14580 Recombinant
 AFUA_4G14580 Antibody
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O-methyltransferase ZRP4

 O-methyltransferase ZRP4 ELISA Kit
 O-methyltransferase ZRP4 Recombinant
 O-methyltransferase ZRP4 Antibody
Also known as O-methyltransferase ZRP4 (OMT).
May be involved in the O-methylation of suberin phenylpropanoid precursors.
 ZRP4 ELISA Kit
 ZRP4 Recombinant
 ZRP4 Antibody
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Proteins Root Name Listing
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