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Oligophrenin

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Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function, in hippocampal neurons. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at pre-synaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation.

Below are the list of possible Oligophrenin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Oligophrenin-1

 Oligophrenin-1 ELISA Kit
 Oligophrenin-1 Recombinant
 Oligophrenin-1 Antibody
OPHN1: Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Defects in OPHN1 are the cause of ment
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al retardation X- linked OPHN1-related (MRXSO); formerly designated MRX60. MRXSO is a syndromic mental retardation. Patients present mental retardation associated with cerebellar hypoplasia and distinctive facial dysmorphism.

Protein type: GAPs; GAPs, Rac/Rho; Motility/polarity/chemotaxis

Cellular Component: actin cytoskeleton; cytoplasm; dendrite; dendritic spine; terminal button

Molecular Function: actin binding; GTPase activator activity; ionotropic glutamate receptor binding; phospholipid binding; protein binding

Biological Process: actin cytoskeleton organization and biogenesis; regulation of endocytosis; regulation of synaptic transmission, glutamatergic; synaptic vesicle endocytosis
 Ophn1 ELISA Kit
 Ophn1 Recombinant
 Ophn1 Antibody
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