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Oxysterols receptor

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Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism. Exhibits a ligand-dependent transcriptional activation activity (By similarity).

Below are the list of possible Oxysterols receptor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Oxysterols receptor LXR-alpha

 Oxysterols receptor LXR-alpha ELISA Kit
 Oxysterols receptor LXR-alpha Recombinant
 Oxysterols receptor LXR-alpha Antibody
Also known as Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3).
LXR-alpha: Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repe
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ats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor

Cellular Component: cytoplasm; nuclear chromatin; nucleus; receptor complex

Molecular Function: DNA binding; ligand-dependent nuclear receptor activity; protein binding; protein heterodimerization activity; retinoid X receptor binding; sequence-specific DNA binding; sterol response element binding; transcription factor activity

Biological Process: apoptotic cell clearance; cellular lipid metabolic process; cholesterol homeostasis; fatty acid biosynthetic process; lipid homeostasis; negative regulation of inflammatory response; negative regulation of lipid transport; negative regulation of macrophage activation; negative regulation of pinocytosis; negative regulation of proteolysis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of cellular protein metabolic process; positive regulation of cholesterol transport; positive regulation of fatty acid biosynthetic process; positive regulation of lipoprotein lipase activity; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to progesterone stimulus; sterol homeostasis
 Nr1h3 ELISA Kit
 Nr1h3 Recombinant
 Nr1h3 Antibody
 Lxra ELISA Kit
 Lxra Recombinant
 Lxra Antibody
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Oxysterols receptor LXR-beta

 Oxysterols receptor LXR-beta ELISA Kit
 Oxysterols receptor LXR-beta Recombinant
 Oxysterols receptor LXR-beta Antibody
Also known as Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor NER) (Nuclear receptor subfamily 1 group H member 2) (Ubiquitously-expressed nuclear receptor).
LXR-beta: Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Forms a heterodimer with RXR. Ubiquitous. Belongs to the nuclear hormone receptor family. NR1 subfamily.

Protein type: Nuclear receptor
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br>Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: apolipoprotein A-I receptor binding; ATPase binding; DNA binding; protein binding

Biological Process: negative regulation of lipid transport; negative regulation of pinocytosis; negative regulation of transcription, DNA-dependent; positive regulation of cellular protein metabolic process; positive regulation of cholesterol transport; positive regulation of fatty acid biosynthetic process; positive regulation of lipoprotein lipase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter
 NR1H2 ELISA Kit
 NR1H2 Recombinant
 NR1H2 Antibody
 LXRB ELISA Kit
 LXRB Recombinant
 LXRB Antibody
 NER ELISA Kit
 NER Recombinant
 NER Antibody
 UNR ELISA Kit
 UNR Recombinant
 UNR Antibody
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