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PAB-dependent poly(A)-specific ribonuclease

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Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Below are the list of possible PAB-dependent poly(A)-specific ribonuclease products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

PAB-dependent poly

 PAB-dependent poly ELISA Kit
 PAB-dependent poly Recombinant
 PAB-dependent poly Antibody
Also known as PAB-dependent poly(A)-specific ribonuclease subunit PAN2 (hPan2) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-nuclease) (PAN deadenylation complex catalytic subunit 2).
USP52: Functions in cytoplasmic mRNA decay. As part of the Pan nuclease complex, shortens poly(A) tails of RNA when the poly(A) stretch is bound by polyadenylate-binding protein. Belongs to the peptidase C19 family. PAN2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.13.4; Ribonuclease; Ubiquitin-specific protease
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br>Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: cytosol

Molecular Function: 3'-5'-exoribonuclease activity; poly(A)-specific ribonuclease activity; protein binding

Biological Process: poly(A) tail shortening
 PAN2 ELISA Kit
 PAN2 Recombinant
 PAN2 Antibody
 KIAA0710 ELISA Kit
 KIAA0710 Recombinant
 KIAA0710 Antibody
 USP52 ELISA Kit
 USP52 Recombinant
 USP52 Antibody
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