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Pancreas transcription factor

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Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.

Below are the list of possible Pancreas transcription factor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Pancreas transcription factor 1 subunit alpha

 Pancreas transcription factor 1 subunit alpha ELISA Kit
 Pancreas transcription factor 1 subunit alpha Recombinant
 Pancreas transcription factor 1 subunit alpha Antibody
Also known as Pancreas transcription factor 1 subunit alpha (Class A basic helix-loop-helix protein 29) (bHLHa29) (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA-binding subunit of transcription factor PTF1) (PTF1-p48).
PTF1A: Transcriptional activator. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays an important role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including E
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LA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Defects in PTF1A are the cause of diabetes mellitus and cerebellar hypoplasia/agenesis (DMCH).

Chromosomal Location of Human Ortholog: 10p12.2

Cellular Component: cytoplasm; nucleus; transcription factor complex

Molecular Function: DNA binding

Biological Process: cerebellum development; exocrine pancreas development; pancreas development; regulation of transcription, DNA-dependent; tissue development

Disease: Pancreatic Agenesis 2; Pancreatic And Cerebellar Agenesis
 PTF1A ELISA Kit
 PTF1A Recombinant
 PTF1A Antibody
 BHLHA29 ELISA Kit
 BHLHA29 Recombinant
 BHLHA29 Antibody
 PTF1P48 ELISA Kit
 PTF1P48 Recombinant
 PTF1P48 Antibody
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