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Pappalysin

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Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.

Below are the list of possible Pappalysin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Pappalysin-1

 Pappalysin-1 ELISA Kit
 Pappalysin-1 Recombinant
 Pappalysin-1 Antibody
Also known as Pappalysin-1 (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase) (Pregnancy-associated plasma protein A) (PAPP-A).
PAPPA: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5
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is slightly inhibited by the presence of IGF. Belongs to the peptidase M43B family.

Protein type: EC 3.4.24.79; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q33.2

Cellular Component: extracellular region

Molecular Function: metalloendopeptidase activity; metallopeptidase activity

Biological Process: cellular protein metabolic process
 PAPPA ELISA Kit
 PAPPA Recombinant
 PAPPA Antibody
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Pappalysin-2

 Pappalysin-2 ELISA Kit
 Pappalysin-2 Recombinant
 Pappalysin-2 Antibody
Also known as Pappalysin-2 (Pregnancy-associated plasma protein A2) (PAPP-A2) (Pregnancy-associated plasma protein E1) (PAPP-E).
PAPPA2: Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3. Belongs to the peptidase M43B family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.-; Protease; Secreted; Se
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creted, signal peptide

Chromosomal Location of Human Ortholog: 1q25.2

Cellular Component: extracellular region

Molecular Function: metalloendopeptidase activity; metallopeptidase activity

Biological Process: cellular protein metabolic process; proteolysis
 PAPPA2 ELISA Kit
 PAPPA2 Recombinant
 PAPPA2 Antibody
 PLAC3 ELISA Kit
 PLAC3 Recombinant
 PLAC3 Antibody
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