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Partitioning defective

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Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Involved in Schwann cell peripheral myelination. Targets the phosphatase PTEN to cell junctions.

Below are the list of possible Partitioning defective products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Partitioning defective 3 homolog

 Partitioning defective 3 homolog ELISA Kit
 Partitioning defective 3 homolog Recombinant
 Partitioning defective 3 homolog Antibody
Also known as Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Atypical PKC-specific-binding protein) (ASBP).
PAR3-alpha: an adapter protein involved in asymmetrical cell division, and cell polarization processes. Polarity complex proteins, including PARD3, are essential for PIP3-induced receptor tyrosine kinase recycling. Seems to pl
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ay a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Association with PARD6B may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons. PDZ 1 domain modulates interactions with JAM1, PARD6A and PARD6B; PDZ 2 domain mediates interaction with membranes containing phosphoinositol lipids; PDZ 3 domain regulates interactions with PTEN (via C-terminus). Belongs to the PAR3 family. 10 isoforms of the human protein are produced by alternative splicing. Isoform 2, but not at least isoform 3 interacts with PRKCZ.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Cellular Component: adherens junction; apical junction complex; apical part of cell; cell cortex; cell junction; cell soma; cell-cell adherens junction; cytoplasm; intercellular junction; internode region of axon; lateral loop; protein complex; spindle; tight junction

Molecular Function: phosphatidylinositol 3-phosphate binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein kinase C binding; protein phosphatase binding

Biological Process: centrosome localization; microtubule cytoskeleton organization and biogenesis; myelination in the peripheral nervous system; positive regulation of myelination; positive regulation of receptor internalization; protein targeting to membrane; regulation of actin filament-based process
 Pard3 ELISA Kit
 Pard3 Recombinant
 Pard3 Antibody
 Par3 ELISA Kit
 Par3 Recombinant
 Par3 Antibody
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Partitioning defective 3 homolog B

 Partitioning defective 3 homolog B ELISA Kit
 Partitioning defective 3 homolog B Recombinant
 Partitioning defective 3 homolog B Antibody
Also known as Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein homolog) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein).
PAR3-beta: Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. Belongs to the PAR3 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
 Pard3b ELISA Kit
 Pard3b Recombinant
 Pard3b Antibody
 Als2cr19 ELISA Kit
 Als2cr19 Recombinant
 Als2cr19 Antibody
 Par3l ELISA Kit
 Par3l Recombinant
 Par3l Antibody
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Partitioning defective 6 homolog alpha

 Partitioning defective 6 homolog alpha ELISA Kit
 Partitioning defective 6 homolog alpha Recombinant
 Partitioning defective 6 homolog alpha Antibody
Also known as Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A).
PARD6A: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links
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GTP-bound Rho small GTPases to atypical protein kinase C proteins. Interacts with MAP2K5. Interacts with PARD3. Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI. Interacts with human T-cell leukemia virus type I TAX protein. Interacts with MPP5 and CRB3. Interacts with TGFBR1; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with ECT2 ('Thr- 359' phosphorylated form) and PRKCI. Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta. Belongs to the PAR6 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Cell adhesion; Motility/polarity/chemotaxis

Cellular Component: actin cytoskeleton; apical part of cell; cell cortex; cell junction; cell soma; centrosome; cytoplasm; nucleus; protein complex; tight junction

Molecular Function: GTP-dependent protein binding; protein binding; protein kinase C binding; Rho GTPase binding

Biological Process: centrosome organization and biogenesis; establishment of cell polarity; intercellular junction maintenance; negative regulation of protein amino acid phosphorylation
 Pard6a ELISA Kit
 Pard6a Recombinant
 Pard6a Antibody
 Par6a ELISA Kit
 Par6a Recombinant
 Par6a Antibody
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Partitioning defective 6 homolog beta

 Partitioning defective 6 homolog beta ELISA Kit
 Partitioning defective 6 homolog beta Recombinant
 Partitioning defective 6 homolog beta Antibody
Also known as Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).
PARD6B: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho
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small GTPases to atypical protein kinase C proteins. Belongs to the PAR6 family.

Protein type: Cell adhesion

Chromosomal Location of Human Ortholog: 20q13.13

Cellular Component: cytoplasm; cytosol; plasma membrane; tight junction

Molecular Function: protein binding

Biological Process: axonogenesis; establishment and/or maintenance of cell polarity; intercellular junction assembly; protein complex assembly; regulation of cell migration
 PARD6B ELISA Kit
 PARD6B Recombinant
 PARD6B Antibody
 PAR6B ELISA Kit
 PAR6B Recombinant
 PAR6B Antibody
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Partitioning defective 6 homolog gamma

 Partitioning defective 6 homolog gamma ELISA Kit
 Partitioning defective 6 homolog gamma Recombinant
 Partitioning defective 6 homolog gamma Antibody
Also known as Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).
PARD6G: Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP- bound Rho small GTPases to atypical protein kinase C proteins. Belongs to the PAR6 family.

Protein type: Adaptor/scaffo
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ld; Cell adhesion; Motility/polarity/chemotaxis

Cellular Component: protein complex
 Pard6g ELISA Kit
 Pard6g Recombinant
 Pard6g Antibody
 Par6g ELISA Kit
 Par6g Recombinant
 Par6g Antibody
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