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PAS domain-containing serine/threonine-protein kinase

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Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.

Below are the list of possible PAS domain-containing serine/threonine-protein kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

PAS domain-containing serine/threonine-protein kinase

 PAS domain-containing serine/threonine-protein kinase ELISA Kit
 PAS domain-containing serine/threonine-protein kinase Recombinant
 PAS domain-containing serine/threonine-protein kinase Antibody
Also known as PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN).
PASK: Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy h
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omeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation. Ubiquitously expressed, with slightly higher expression in brain, prostate and testis. Reduced expression was found in placenta. Present in germ cells of testis and in the midpiece of sperm tails. Protein kinase activity is inhibited by the first PAS domain: binding of an unidentified ligand desinhibits the protein kinase activity. May be activated by autophosphorylation on Thr-1161 and Thr-1165 (PubMed:11459942). The activating role of autophosphorylation at Thr-1161 is unclear: according to a report, autophosphorylation at Thr-1161 does not play a major role in activation (PubMed:20943661). Autophosphorylation is enhanced upon phosphatidylinositol monophosphate (phosphatidylinositol 4-phosphate) binding and inhibited upon phosphatidylinositol bi- and tri-phosphate binding. In contrast, phosphorylation of target proteins is inhibited upon all phosphatidylinositol-binding (phosphatidylinositol mono- bi- and tri-phosphate). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: CAMK group; CAMKL family; EC 2.7.11.1; Kinase, protein; PASK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)

Cellular Component: cytoplasm; Golgi apparatus; intracellular; nucleus

Molecular Function: phosphoinositide binding; protein serine/threonine kinase activity

Biological Process: negative regulation of glycogen biosynthetic process; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of respiratory gaseous exchange
 Pask ELISA Kit
 Pask Recombinant
 Pask Antibody
 Kiaa0135 ELISA Kit
 Kiaa0135 Recombinant
 Kiaa0135 Antibody
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