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Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).

Below are the list of possible Paxillin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.


 Paxillin ELISA Kit
 Paxillin Recombinant
 Paxillin Antibody
PXN: a multi-domain cytoskeletal protein involved in actin-membrane attachment that localizes primarily to focal adhesion sites to the extracellular matrix. Phosphorylated by focal adhesion kinase (FAK) and is a component of integrin signaling. Its phosphorylation provides docking sites for recruitment of signaling molecules to focal adhesions. Binds in vitro to vinculin as well as to the SH3 dom
ain of c-SRC and, when tyrosine phosphorylated, to the Crk SH2 domain. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1. Binds DDEF2. Interacts with unphosphorylated ITGA4. Interacts with RNF5.Three alternatively-spliced isoforms have been described. Isoform beta binds to focal adhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to focal adhesion kinase.

Protein type: Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis

Cellular Component: cytoplasm; focal adhesion; lamellipodium; leading edge; nucleoplasm; plasma membrane; stress fiber

Molecular Function: beta-catenin binding; BH4 domain binding; integrin binding; protein complex binding; protein kinase binding; vinculin binding

Biological Process: activation of MAPK activity; branching morphogenesis of a tube; cytoskeleton organization and biogenesis; focal adhesion formation; integrin-mediated signaling pathway; lamellipodium biogenesis; peptidyl-tyrosine phosphorylation; positive regulation of protein kinase activity; regulation of cell shape; transforming growth factor beta receptor signaling pathway
 Pxn ELISA Kit
 Pxn Recombinant
 Pxn Antibody
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Paxillin homolog 1

 Paxillin homolog 1 ELISA Kit
 Paxillin homolog 1 Recombinant
 Paxillin homolog 1 Antibody
 pxl-1 ELISA Kit
 pxl-1 Recombinant
 pxl-1 Antibody
 tag-327 ELISA Kit
 tag-327 Recombinant
 tag-327 Antibody
 C28H8.6 ELISA Kit
 C28H8.6 Recombinant
 C28H8.6 Antibody
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 Paxillin-B ELISA Kit
 Paxillin-B Recombinant
 Paxillin-B Antibody
Required for cell-substrate adhesion, cell sorting, slug migration, and cell differentiation. May function upstream of limB.
 paxB ELISA Kit
 paxB Recombinant
 paxB Antibody
 DDB_G0274109 ELISA Kit
 DDB_G0274109 Recombinant
 DDB_G0274109 Antibody
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Proteins Root Name Listing
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