| Paxillin ELISA Kit|
|PXN: a multi-domain cytoskeletal protein involved in actin-membrane attachment that localizes primarily to focal adhesion sites to the extracellular matrix. Phosphorylated by focal adhesion kinase (FAK) and is a component of integrin signaling. Its phosphorylation provides docking sites for recruitment of signaling molecules to focal adhesions. Binds in vitro to vinculin as well as to the SH3 dom |
ain of c-SRC and, when tyrosine phosphorylated, to the Crk SH2 domain. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1. Binds DDEF2. Interacts with unphosphorylated ITGA4. Interacts with RNF5.Three alternatively-spliced isoforms have been described. Isoform beta binds to focal adhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to focal adhesion kinase.
Protein type: Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis
Cellular Component: cytoplasm; focal adhesion; lamellipodium; leading edge; nucleoplasm; plasma membrane; stress fiber
Molecular Function: beta-catenin binding; BH4 domain binding; integrin binding; protein complex binding; protein kinase binding; vinculin binding
Biological Process: activation of MAPK activity; branching morphogenesis of a tube; cytoskeleton organization and biogenesis; focal adhesion formation; integrin-mediated signaling pathway; lamellipodium biogenesis; peptidyl-tyrosine phosphorylation; positive regulation of protein kinase activity; regulation of cell shape; transforming growth factor beta receptor signaling pathway
| Pxn ELISA Kit|